NEUROMODULATION AND/OR NEUROSTIMULATION SYSTEM
A system for neuromodulation or neurostimulation comprising at least one sensing unit configured to provide a sensor signal correlating with a physiological value describing neurological function or dysfunction of a patient, at least one control unit, at least one stimulation unit, and at least one of at least one Central Nervous System stimulation module for providing Central Nervous System stimulation or at least one Peripheral Nervous System stimulation module for providing Peripheral Nervous System stimulation, wherein the control unit is configured to detect the neurological dysfunction based on the sensor signal and to trigger the neuromodulation or neurostimulation. The disclosure further relates to a method for providing neuromodulation or neurostimulation and the use of a neuromodulation system in the method for the treatment of a patient.
1 . A system for neuromodulation or neurostimulation comprising:
at least one sensing unit configured to provide a sensor signal correlating with a physiological value describing neurological function or dysfunction of a patient;
at least one control unit;
at least one stimulation unit; and
at least one of
at least one Central Nervous System stimulation module for providing Central Nervous System stimulation; or
at least one Peripheral Nervous System stimulation module for providing Peripheral Nervous System stimulation;
wherein the control unit is configured to detect the neurological dysfunction based on the sensor signal and to trigger the neuromodulation or neurostimulation.
2 . The system of claim 1 , wherein at least one of the components of the system is implantable.
3 . The system of claim 1 , wherein the at least one sensing unit comprises:
at least one of an electrocardiogram, an electroencephalogram, or an electromyogram;
a patch clamp;
a voltage clamp;
an extracellular single-unit recorder; or
a recorder of local field potentials.
4 . The system of claim 1 , wherein the at least one sensing unit comprises at least one of a blood pressure sensor, a pulse oximeter, a heart-rate sensor, a breathing rate sensor, a body temperature sensor, a pressure sensor, a pH sensor, a barometer, an inertial measurement unit, an accelerometer, a gyroscope, a chemical concentration sensor (glucose, water, sodium, calcium), a hormone sensor, a metabolites sensor, a sweat sensor, a gastrointestinal movement sensor, a hydration sensor, an electrolyte sensor, an arterial stiffness sensor, a urine concentration sensor, a urine volume sensor, a bladder volume sensor, a conductivity sensor, a capacitance sensor, a strain gauge sensor, or a genital blood flow sensor.
5 . The system of claim 1 , wherein the at least one of the at least one sensing unit and the control unit is configured to optimize stimulation parameters for stabilization, or treatment, or both, of the neurological function of a patient.
6 . The system of claim 1 , wherein the at least one sensing unit comprises at least one trigger configured to be triggered by a patient and providing a signal describing dysfunction of an autonomic function of a patient.
7 . The system of claim 6 , wherein the at least one trigger is a manual trigger.
8 . The system of claim 1 , wherein the Central Nervous System stimulation module comprises at least one of:
an epidural stimulation module capable to provide epidural stimulation;
a trans-cutaneous stimulation module capable to provide trans-cutaneous stimulation;
a subdural stimulation module capable to provide subdural stimulation;
an intracortical stimulation module capable to provide intracortical stimulation; or
an intraspinal stimulation module capable to provide intraspinal stimulation.
9 . The system of claim 1 , wherein the Peripheral Nervous System stimulation module is a Functional Electrical Stimulation module capable to provide electrical stimulation of peripheral nerves.
10 . The system of claim 1 , wherein
the Central Nervous System stimulation module is at least partially implantable or at least partially implanted; or
the Peripheral Nervous System stimulation module is at least partially implantable or at least partially implanted; or
the Central Nervous System stimulation module is at least partially implantable or at least partially implanted, and the Peripheral Nervous System stimulation module is at least partially implantable or at least partially implanted.
11 . The system of claim 1 , wherein the system is a closed-loop system.
12 . The system of claim 1 , wherein the system is an open-loop system.
13 . The system of claim 1 , wherein the components of the system form partially an open-loop system and partially closed-loop system.
14 . The system of claim 1 , wherein the control unit is configured for real-time control.
15 . The system of claim 1 , wherein the control unit is configured such that the Peripheral Nervous System stimulation provided by the Peripheral Nervous System stimulation module and the Central Nervous System stimulation provided by the Central Nervous System stimulation module is at least partially interleaved.
16 . The system of claim 1 , wherein the control unit is configured such that the Peripheral Nervous System stimulation provided by the Peripheral Nervous System stimulation module and the Central Nervous System stimulation provided by the Central Nervous System stimulation module is at least partially superimposed.
17 . The system of claim 1 , wherein the control unit is capable to independently control and switch on and off either the Peripheral Nervous System stimulation module or the Central Nervous System stimulation module.
18 . The system of claim 1 , wherein the system is configured to be combined with at least one additional system of claim 1 ,
wherein the control unit is configured to trigger that at least one of the Peripheral Nervous System stimulation provided by the Peripheral Nervous System stimulation module or the Central Nervous System stimulation provided by the Central Nervous System stimulation module of the system is at least partially used for correction of effects of stimulation provided by the at least one additional system of claim 1 .
19 . A method for providing at least one of neuromodulation or neurostimulation to treat a patient's neurological dysfunction by using a system, the system for neuromodulation or neurostimulation comprising:
at least one sensing unit configured to provide a sensor signal correlating with a physiological value describing the neurological dysfunction;
at least one control unit;
at least one stimulation unit; and
at least one of
at least one Central Nervous System stimulation module for providing Central Nervous System stimulation; or
at least one Peripheral Nervous System stimulation module for providing Peripheral Nervous System stimulation;
wherein the control unit is configured to detect the neurological dysfunction on the sensor signal and to trigger at least one of neuromodulation for stabilization or treatment of the neurological function of the patient.
20 . The method of claim 19 , the patient's neurological dysfunction comprises an autonomic dysfunction, an after-spinal cord injury, a traumatic brain injury, cerebral palsy, stroke, Parkinson Disease, multiple sclerosis, autonomic failure, autonomic neuropathy, or cancer of the neurological tissue.