IP Library Granted Patent US 12,329,889
Granted Patent B2
US 12,329,889 · App. 17/306,214 · Granted Jun 17, 2025

Reducing sorbent cartridge recharging requirements

Inventor: Arindam G. Roy (Bangalore, IN)
Assignee: Mozarc Medical US LLC
A61M1/1696A61M1/1601B01J20/0211B01J20/0292B01J20/06B01J20/3236A61M2205/0205A61M2205/60B01J2220/62
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Quick Facts
Patent No.
US 12,329,889
App. No.
17/306,214
Granted
Jun 17, 2025
Kind
B2
Abstract

Systems and methods for reducing the burden of recharging on patients and caregivers are provided. The systems and methods use a microbe removal layer upstream of a sorbent cartridge in a sorbent-based dialysis system. The systems and methods can determine whether the bacterial content and remaining capacity of a non-recharged sorbent module are suitable for the sorbent module to be reused safely and effectively without recharging.

Claims (35)

1. A system, comprising:

a sorbent module containing at least zirconium oxide and/or zirconium phosphate;

a microbe removal layer upstream of the sorbent module; and

a control system programmed to:

calculate a remaining capacity of the sorbent module following a first dialysis session, wherein the remaining capacity of the sorbent module following the first dialysis session is a function of at least a weight of a patient;

calculate an estimated capacity of the sorbent module that would be required for a second dialysis session, wherein the second dialysis session would follow the first dialysis session; and

determine if the sorbent module can be reused for the second dialysis session, without recharging the sorbent module, based on the remaining capacity of the sorbent module and the capacity of the sorbent module required for the second dialysis session,

wherein the capacity of the sorbent module required for the second dialysis session is based on at least an expected dialysate flow rate through the sorbent module for the second dialysis session and expected duration of the second dialysis session.

2. The system of claim 1 , wherein the microbe removal layer is either silver impregnated activated carbon or a halide resin and silver impregnated activated carbon.

3. The system of claim 1 , wherein the sorbent module contains zirconium oxide.

4. The system of claim 1 , wherein the sorbent module contains zirconium phosphate.

5. The system of claim 1 , further comprising an identification component affixed to or embedded in the sorbent module.

6. The system of claim 5 , wherein the identification component is an RFID component.

7. The system of claim 5 , wherein the control system is programmed to determine whether the sorbent module is usable in a present dialysis session based on data from the identification component.

8. The system of claim 7 , wherein the control system is programmed to determine that the sorbent module is usable if the remaining capacity of the sorbent module is above a preset value and either of:

a) the sorbent module has not been used in a dialysis session since a last recharge; or

b) the sorbent module has been used in a prior dialysis session since the last recharge and the prior dialysis session was within a preset length of time of the present dialysis session.

9. The system of claim 8 , wherein the preset length of time is about 36 hours.

10. The system of claim 8 , wherein the remaining capacity of the sorbent module is determined based on a volume of dialysate passed through the sorbent module in the prior dialysis session.

11. A method, comprising the steps of:

determining whether a first sorbent module containing zirconium oxide and/or zirconium phosphate is useable in a present dialysis session; wherein the first sorbent module was used in a prior dialysis session; and wherein during the prior dialysis session, a microbe removal layer was upstream of the zirconium oxide and/or zirconium phosphate;

calculating, by a control system, a remaining capacity of the first sorbent module following the prior dialysis session, wherein the remaining capacity of the first sorbent module following the prior dialysis session is a function of at least a weight of a patient;

calculating, by the control system, an estimated capacity of the first sorbent module that would be required for the present dialysis session, wherein the present dialysis session would follow the prior dialysis session; and

determining, by the control system, if the first sorbent module can be reused for the present dialysis session, without recharging the first sorbent module, based on the remaining capacity of the first sorbent module and the capacity of the first sorbent module required for the present dialysis session,

wherein the capacity of the first sorbent module required for the present dialysis session is based on at least an expected dialysate flow rate through the first sorbent module for the present dialysis session and expected duration of the present dialysis session.

12. The method of claim 11 , wherein the first sorbent module is determined to be useable if the remaining capacity of the first module is above a preset value and if either:

a) the first sorbent module has not been used in the dialysis session since a last recharge; or

b) the first sorbent module has been used in the prior dialysis session since the last recharge and the prior dialysis session was within a preset length of time of the present dialysis session.

13. The method of claim 12 , wherein data used to determine whether the first sorbent module is usable is obtained from an identification component affixed to or embedded in the first sorbent module.

14. The method of claim 11 , wherein the microbe removal layer is either silver impregnated activated carbon or a halide resin and silver impregnated activated carbon.

15. The method of claim 11 , wherein the first sorbent module contains zirconium oxide.

16. The method of claim 11 , wherein the first sorbent module contains zirconium phosphate.

17. The method of claim 11 , wherein the microbe removal layer was in a second sorbent module.

18. The method of claim 11 , wherein the step of determining whether the first sorbent module is usable is performed by a control system of a dialysis system.

19. The method of claim 11 , further comprising the step of performing dialysis with the first sorbent module if the first sorbent module is determined to be usable.

Assignments (4)
SECURITY INTEREST Recorded Dec 1, 2025
From: MOZARC MEDICAL US LLC
To: ORBIMED ROYALTY & CREDIT OPPORTUNITIES V, LP
Reel/Frame 073800/0164 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 19, 2023
From: MEDTRONIC, INC.
To: MOZARC MEDICAL US LLC
Reel/Frame 063375/0659 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 21, 2022
From: ROY, ARINDAM GHOSH
To: INDIA MEDTRONIC PRIVATE LIMITED
Reel/Frame 060260/0171 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 21, 2022
From: INDIA MEDTRONIC PRIVATE LIMITED
To: MEDTRONIC, INC.
Reel/Frame 060260/0251 →
Continuity (1)
Related Publication 20220347361A1 · Nov 3, 2022
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