Albumin binding domain fusion proteins
Compositions that include an albumin binding domain and a fusion partner (e.g., a cytokine or a binding moiety) are provided. Such therapeutics have increased serum half-life and find use in applications where one or more such therapeutics are needed, for example, in oncology applications.
1. An IL-12 albumin binding domain fusion protein comprising the amino acid sequence of SEQ ID NO: 280.
2. A nucleic acid encoding the IL-12 albumin binding domain fusion protein of claim 1 .
3. An expression vector comprising the nucleic acid of claim 2 .
4. A host cell comprising the nucleic acid of claim 2 or the expression vector of claim 3 .
5. A method of making the IL-12 albumin binding domain fusion protein comprising culturing the host cell of claim 4 under conditions wherein the IL-12 albumin binding domain fusion protein is expressed, and recovering the IL-12 albumin binding domain fusion protein.