PROBIOTICS FOR COGNITIVE AND MENTAL HEALTH
The invention relates to compositions comprising Lactobacillus plantarum , and methods and uses of said compositions for preventing and/or treating mental illness, symptoms affecting mental health and/or conditions associated with chronic stress, in a mammal. The invention can be applied in restoring, maintaining, and/or promoting mental (including cognitive) health and has potential applications, inter alia, in the area of dietary and food supplements, medicaments and pharmaceuticals.
1 . (canceled)
2 . A method of preventing and/or treating a mental illness, a symptom affecting mental health and/or a condition associated with chronic stress in a mammal in need thereof, wherein the method comprises administering to the mammal Lactobacillus plantarum is strain LP12151 deposited with DSMZ on Jan. 9, 2018 under accession number DSM 32721.
3 . The method according to claim 2 , wherein:
the method comprises preventing and/or treating a mental illness; and
the mental illness is a mood disorder, an anxiety disorder and/or depression.
4 . The method according to claim 2 , wherein:
the method comprises preventing and/or treating a symptom affecting mental health; and
the symptom affecting mental health is anxiety, mood swings and/or depression
5 . The method according to claim 2 , wherein:
the method comprises preventing and/or treating a condition associated with chronic stress; and
the condition associated with chronic stress is a gastrointestinal disorder.
6 . (canceled)
7 . A composition comprising:
Lactobacillus plantarum , strain LP12151 deposited with DSMZ on Jan. 9, 2018 under accession number DSM 32721; and
a second ingredient selected from a nutritionally acceptable carrier, a nutritionally acceptable diluent, a nutritionally acceptable excipient, a nutritionally acceptable adjuvant, a nutritionally active ingredient, a dietary ingredient, a pharmaceutically acceptable carrier, a pharmaceutically acceptable diluent, a pharmaceutically acceptable excipient, a pharmaceutically acceptable adjuvant, and a pharmaceutically active ingredient.
8 . A method of preventing and/or treating a mental illness, a symptom affecting mental health and/or a condition associated with chronic stress in a mammal in need thereof, wherein the method comprises administering to the mammal a composition of claim 7 .
9 . The composition according to claim 7 , wherein the second ingredient comprises another bacterial strain.
10 . The composition according to claim 7 , wherein the second ingredient comprises a prebiotic.
11 . The composition according to claim 10 , wherein the prebiotic is polydextrose.
12 . The composition according to claim 7 , wherein the composition is in the form of a food product, a beverage, a dietary supplement or a pharmaceutically acceptable formulation or composition.
13 . The composition according to claim 7 , wherein the composition is a spray dried or freeze-dried composition.
14 . The composition according to claim 13 , wherein the composition comprises a cryoprotectant.
15 . The composition according to claim 7 , wherein:
the composition is in unit dosage form, and
the Lactobacillus plantarum strain LP12151 is present in the composition in an amount between 10 6 and 10 12 CFU per unit dose.
16 . The method according to claim 8 , wherein the mental illness is a mood disorder, an anxiety disorder and/or depression.
17 . The method according to claim 8 , wherein the symptom affecting mental health is anxiety, mood swings and/or depression.
18 . The method according to claim 8 , wherein the condition associated with chronic stress is a gastrointestinal disorder.
19 . A composition, wherein:
the composition comprises Lactobacillus plantarum strain LP12151;
the composition is spray dried or freeze-dried, and
the composition comprises a cryoprotectant.
20 . The composition of claim 19 , wherein the cryoprotectant comprises glucose, sucrose, lactose, trehalose or sodium ascorbate.
21 . The method according to claim 5 , wherein the gastrointestinal disorder comprises irritable bowel syndrome.
22 . The composition according to claim 15 , wherein:
the composition is in unit dosage form, and
the Lactobacillus plantarum strain LP12151 is present in the composition in an amount between 10 8 and 10 12 CFU per unit dose.