COMBINATION THERAPIES FOR TREATING DISEASE USING AN INNATE IMMUNITY MODIFIER AND AN OX40 AGONIST
The present disclosure provides methods of treating cancer comprising administering a selective dipeptidyl peptidase inhibitor and an OX40 agonist with or without one or more immune checkpoint inhibitors to a subject with cancer. The present disclosure provides pharmaceutical compositions for treating cancer comprising a selective dipeptidyl peptidase inhibitor and an OX40 agonist with or without one or more immune checkpoint inhibitors.
1 . A method of treating cancer in a subject in need thereof, the method comprising administering to the subject therapeutically effective amounts of a dipeptidyl peptidase inhibitor and an OX40 agonist.
2 . A method of generating an anti-tumor immune response in a subject with cancer, the method comprising administering to the subject therapeutically effective amounts of a dipeptidyl peptidase inhibitor and an OX40 agonist.
3 . The method of claim 1 or 2 , further comprising administration of therapeutically effective amounts of one or more immune checkpoint inhibitors.
4 . The method of any one of claims 1 - 3 , wherein the dipeptidyl peptidase inhibitor is selected from the group consisting of a compound or an antibody, preferably a compound.
5 . The method of claim 4 , wherein the compound is talabostat or an analog, a prodrug, a stereoisomer, or a pharmaceutically acceptable salt thereof.
6 . The method of claim 4 , wherein the dipeptidyl peptidase inhibitor is talabostat or a pharmaceutically acceptable salt thereof.
7 . The method of claim 4 , wherein the dipeptidyl peptidase inhibitor is talabostat mesylate.
8 . The method of claim 4 , wherein the dipeptidyl peptidase inhibitor is an analog of talabostat.
9 . The method of claim 4 , wherein the dipeptidyl peptidase inhibitor is ARI-4175.
10 . The method of claim 4 , wherein the dipeptidyl peptidase inhibitor is a prodrug of talabostat.
11 . The method of claim 4 , wherein the dipeptidyl peptidase inhibitor is cyclohexyl(glycinyl)-prolinyl-valinyl-L-boroproline
12 . The method of any one of claims 1 - 11 , wherein the OX40 agonist is selected from the group consisting of an antibody, an oligomeric or multimeric molecule, a fusion protein, an OX40L agonist fragment and an immunoadhesin.
13 . The method of claim 12 , wherein the OX40 agonist is an antibody.
14 . The method of any one of claims 1 - 11 , wherein the OX40 agonist is selected from the group consisting of PF-04518600, pogalizumab (MOXR0916, RG 7888), MEDI6469, L106, ACT35, OX86, MEDI0562 (tavolixizumab, tavolimab), INCAGN01949 and GSK3174998.
15 . The method of any one of claims 1 - 11 , wherein the OX40 agonist is PF-04518600.
16 . The method of any one of claims 3 - 15 , wherein the one or more immune checkpoint inhibitors is a PD-1 axis inhibitor and/or a CTLA4 inhibitor.
17 . The method of claim 16 , wherein the PD-1 axis inhibitor comprises a PD-1 inhibitor, a PD-L1 inhibitor, or a PD-L2 inhibitor.
18 . The method of any one of claims 3 - 15 , wherein the one or more immune checkpoint inhibitors is a PD-1 inhibitor selected from the group consisting of ANA011, AUNP-12, tislelizumab (BGB-A317), KD033, pembrolizumab, MCLA-134, mDX400, MEDI0680, muDX400, nivolumab, spartalizumab (PDR001), sasanlimab (PF-06801591), cemiplimab (semiprimab, REGN-2810), camrelizumab (SHR 1210), STI-Al110, dostarlimab (TSR-042 or TSR042 or ANB0ll), 244C8, 388D4, prolgolimab (BCD100), camrelizumab (SHR 1210), cetrelimab (JNJ63723283), JS001, XCE853, GLS-010 (AB-122; WBP-3055), sintilimab (IBI-308), genolimzumab (CBT-501, GB226, APL-501), AK-103, theralizumab (TGN1412, CD28-SuperMAB, TAB-08 and TAB08), BI-754091, INCMGA00012 (MGA 012, INCMGA-0012), ABBV-181 (budigalimab), CC-90006 (C-90006), AGEN-2034w (AGEN-2034), LZM-009, Sym021, AK-105, CS1003, HLX-10 and AMP-224, preferably pembrolizumab or nivolumab.
19 . The method of any one of claims 3 - 15 , wherein the one or more immune checkpoint inhibitors is a PD-L1 inhibitor selected from a group consisting of avelumab, BMS-936559, BMS-986189, CA-170, CK-301 (cosibelimab), lodapolimab (LY-3300054), CX-072, CBT-502 (TQB2450), FAZ-053, FS118, HTI-1088 (HTI-1316; SHR 1316), MSB 2311, BGB-A333, IMC-001(STI-3031; STI-A1015KN035), HLX-20, A 167 (HBM-9167; KL-A167), KD033, durvalumab, KN035, MCLA-145, SP142, STI-A1011, STI-A1012, STI-A1010, STI-A1013, STI-A1014, STI-A1015, A110, KY1003, KD033 and atezolizumab, preferably avelumab.
20 . The method of any one of claims 3 - 15 , wherein the one or more immune checkpoint inhibitors is the PD-L2 inhibitor rHIgM12B7.
21 . The method of any one of claims 3 - 15 , wherein the one or more immune checkpoint inhibitors is a CTLA4 inhibitor selected from the group consisting of KAHR-102, AGEN1884, KN044, BMS-986218, MK-1308, ADU-1604, BMS-986249, CS-1002, BCD-145, REGN-4659, tremelimumab and ipilimumab, preferably tremelimumab or ipilimumab.
22 . The method of any one of claims 1 - 21 , wherein the dipeptidyl peptidase inhibitor is administered at a dose from about 0.001 mg/kg to about 1 mg/kg, preferably about 0.001 mg/kg to about 0.05 mg/kg, or more preferably about 0.001 mg/kg to about 0.035 mg/kg.
23 . The method of any one of claims 1 - 22 , wherein the OX40 agonist is administered at a dose from about 0.01 mg/kg to about 20 mg/kg body, preferably about 0.1 mg/kg to about 10 mg/kg, or more preferably about 0.1 mg/kg to about 5 mg/kg.
24 . The method of claim 17 or 18 , wherein the PD-1 inhibitor is administered at a dose of about 0.1 mg/kg to about 20 mg/kg, preferably about 0.3 mg/kg to about 10 mg/kg, or more preferably about 1 mg/kg to about 3 mg/kg.
25 . The method of any one of claims 1 - 24 , wherein the dipeptidyl peptidase inhibitor and the OX40 agonist are administered together as part of a single dosage form.
26 . The method of any one of claims 1 - 24 , wherein the dipeptidyl peptidase inhibitor and the OX40 agonist are administered together as two separate dosage forms.
27 . The method of any one of claims 3 - 24 , wherein the dipeptidyl peptidase inhibitor, the OX40 agonist and one or more immune checkpoint inhibitors are administered together as part of a single dosage form.
28 . The method of any one of claims 3 - 24 , wherein the dipeptidyl peptidase inhibitor, the OX40 agonist and one or more immune checkpoint inhibitors are administered as three or more separate dosage forms.
29 . The method of any one of claims 1 - 28 , wherein the cancer is selected from the group consisting of melanoma, metastatic melanoma, oral squamous cell carcinoma, small cell lung cancer, breast cancer, colorectal cancer, colon cancer, pancreatic cancer, lung cancer, glioblastoma, hepatocellular carcinoma, head and neck cancer, leukemia, lymphoma, sarcoma, fibrosarcoma, lymphocytic leukemia, non-Hodgkin's lymphoma, Hodgkin's lymphoma, anaplastic large-cell lymphoma, myeloid leukemia, multiple myeloma, acute lymphoblastic leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, prostate cancer, neuroendocrine prostate cancer, hormone refractory prostate cancer, castration resistant prostate cancer, androgen resistant prostate cancer, treatment resistant prostate cancer and acute myeloid leukemia, preferably prostate cancer, pancreatic cancer and colorectal cancer.
30 . The method of any one of claims 1 - 28 , wherein the cancer is colorectal cancer.
31 . The method of any one of claims 1 - 28 , wherein the cancer is pancreatic cancer.
32 . The method of any one of claims 1 - 28 , wherein the cancer is prostate cancer.
33 . The method of claim 1 or 2 , wherein the dipeptidyl peptidase inhibitor is talabostat mesylate and the OX40 agonist is PF-04518600.
34 . The method of claim 3 , wherein the dipeptidyl peptidase inhibitor is talabostat mesylate and the OX40 agonist is PF-04518600.
35 . The method of claim 3 , wherein the dipeptidyl peptidase inhibitor is talabostat mesylate, the OX40 agonist is PF-04518600, and the one or more immune checkpoint inhibitors is a PD-1 inhibitor and/or a CTLA4 inhibitor.
36 . The method of claim 3 , wherein the dipeptidyl peptidase inhibitor is talabostat mesylate, the OX40 agonist is PF-04518600, and the one or more immune checkpoint inhibitors is a PD-1 inhibitor.
37 . The method of claim 3 , wherein the dipeptidyl peptidase inhibitor is talabostat mesylate, the OX40 agonist is PF-04518600, and the immune checkpoint inhibitor is nivolumab.
38 . The method of claim 3 , wherein the dipeptidyl peptidase inhibitor is talabostat mesylate, the OX40 agonist is PF-04518600, and the immune checkpoint inhibitor is pembrolizumab.
39 . The method of claim 3 , wherein the dipeptidyl peptidase inhibitor is talabostat mesylate, the OX40 agonist is PF-04518600, and the immune checkpoint inhibitor is avelumab.
40 . A pharmaceutical composition for the treatment of cancer comprising:
(i) a therapeutically effective amount of a dipeptidyl peptidase inhibitor,
(ii) a therapeutically effective amount of an OX40 agonist, and
(iii) one or more pharmaceutically acceptable carriers and/or excipients.
41 . A pharmaceutical composition for the treatment of cancer comprising:
(i) a therapeutically effective amount of a dipeptidyl peptidase inhibitor,
(ii) a therapeutically effective amount of an OX40 agonist,
(iii) a therapeutically effective amount of one or more immune checkpoint inhibitors, and
(iv) one or more pharmaceutically acceptable carriers and/or excipients.
42 . The pharmaceutical composition of claim 41 , wherein the one or more immune checkpoint inhibitors comprises a PD-1 axis inhibitor and/or a CTLA4 inhibitor.
43 . The pharmaceutical composition of claim 42 , wherein the PD-1 axis inhibitor comprises a PD-1 inhibitor, a PD-L1 inhibitor, and/or a PD-L2 inhibitor.
44 . The pharmaceutical composition of claim 41 , wherein the immune checkpoint inhibitor is a PD-1 inhibitor selected from the group consisting of ANA011, AUNP-12, tislelizumab (BGB-A317), KD033, pembrolizumab, MCLA-134, mDX400, MEDI0680, muDX400, nivolumab, spartalizumab (PDR001), sasanlimab (PF-06801591), cemiplimab (Semiprimab, REGN-2810), camrelizumab (SHR 1210), STI-Al110, dostarlimab (TSR-042 or TSR042 or ANB0ll), 244C8, 388D4, prolgolimab (BCD100), cetrelimab (JNJ63723283), JS001, XCE853, GLS-010 (AB-122; WBP-3055), sintilimab (IBI-308), genolimzumab (CBT-501, GB226, APL-501), AK-103, theralizumab (TGN1412, CD28-SuperMAB, TAB-08 and TAB08), BI-754091, INCMGA00012 (MGA 012, INCMGA-0012), ABBV-181 (Budigalimab), CC-90006 (C-90006), AGEN-2034w (AGEN-2034), LZM-009, Sym021, AK-105, CS1003, HLX-10, and AMP-224, preferably pembrolizumab or nivolumab.
45 . The pharmaceutical composition of claim 41 , wherein the immune checkpoint inhibitor is a PD-L1 inhibitor selected from the group consisting of avelumab, BMS-936559, BMS-986189, CA-170, durvalumab, KN035, MCLA-145, SP142, STI-A1011, STI-A1012, STI-A1010, STI-A1013, STI-A1014, STI-A1015, A110, KY1003, KD033 and atezolizumab, preferably avelumab.
46 . The pharmaceutical composition of claim 41 , wherein the immune checkpoint inhibitor is the PD-L2 inhibitor rHIgM12B7.
47 . The pharmaceutical composition of claim 41 , wherein the immune checkpoint inhibitor is a CTLA-4 inhibitor selected from the group consisting of KAHR-102, AGEN1884, BMS-986218, MK-1308, ADU-1604, BMS-986249, CS-1002, BCD-145, REGN-4659, KN044, tremelimumab and ipilimumab, preferably tremelimumab or ipilimumab.
48 . The pharmaceutical composition of any one of claims 40 - 47 , wherein the dipeptidyl peptidase inhibitor is talabostat mesylate.
49 . The pharmaceutical composition of any one of claims 40 - 48 , wherein the OX40 agonist is selected from the group consisting of PF-04518600, pogalizumab (MOXR0916, RG7888), MEDI6469, efizonerimod alfa (MEDI 6383), L106 BD, ACT35, OX86, MEDI0562 (tavolixizumab/tavolimab), INCAGN01949, and GSK3174998, preferably PF-04518600.
50 . The pharmaceutical composition of any one of claims 40 - 49 , wherein the pharmaceutical composition is administered together as part of a single dosage form.
51 . The pharmaceutical composition of any one of claims 40 - 49 , wherein the pharmaceutical composition is administered together as two or more separate dosage forms.
52 . The pharmaceutical composition of any one of claims 40 - 51 , wherein the pharmaceutical composition is administered by the oral or parenteral route.
53 . A kit comprising:
(i) a single dose or multiple doses of a dipeptidyl peptidase inhibitor,
(ii) a single dose or multiple doses of an OX40 agonist, and
(iii) instructions for using the dipeptidyl peptidase inhibitor and OX40 agonist to treat a subject with cancer.
54 . A kit comprising:
(i) a single dose or multiple doses of a dipeptidyl peptidase inhibitor,
(ii) a single dose or multiple doses of an OX40 agonist,
(iii) a single dose or multiple doses of one or more immune check point inhibitors, and
(iv) instructions for using the dipeptidyl peptidase inhibitor, OX40 agonist and immune checkpoint inhibitor(s) to treat a subject with cancer.
55 . The kit according to claim 54 , wherein the immune check point inhibitor is a PD-1 axis inhibitor or a CTLA4 inhibitor.
56 . The kit according to claim 55 , wherein the PD-1 axis inhibitor is a PD-1 inhibitor.
57 . The kit according to claim 54 , wherein the immune check point inhibitor is a PD-1 inhibitor selected from the group consisting of ANA011, AUNP-12, tislelizumab (BGB-A317), KD033, pembrolizumab, MCLA-134, mDX400, MEDI0680, muDX400, nivolumab, spartalizumab (PDR001), sasanlimab (PF-06801591), cemiplimab (Semiprimab, REGN-2810), camrelizumab (SHR 1210), STI-Al110, dostarlimab (TSR-042 or TSR042 or ANB0ll), 244C8, 388D4, prolgolimab (BCD100), cetrelimab (JNJ63723283), JS001 XCE853, GLS-010 (AB-122; WBP-3055), sintilimab (IBI-308), genolimzumab (CBT-501, GB226, APL-501), AK-103, theralizumab (TGN1412, CD28-SuperMAB, TAB-08 and TAB08), BI-754091, INCMGA00012 (MGA 012, INCMGA-0012), ABBV-181 (Budigalimab), CC-90006 (C-90006), AGEN-2034w (AGEN-2034), LZM-009, Sym021, AK-105, CS1003, HLX-10, and AMP-224, preferably pembrolizumab or nivolumab.
58 . The kit according to claim 54 , wherein the immune check point inhibitor is a CTLA4 inhibitor selected from the group consisting of KAHR-102, AGEN1884, BMS-986218, MK-1308, ADU-1604, BMS-986249, CS-1002, BCD-145, REGN-4659, KN044, tremelimumab and ipilimumab, preferably tremelimumab or ipilimumab.
59 . The kit according to any one of claims 53 - 58 , wherein the dipeptidyl peptidase inhibitor is talabostat mesylate.
60 . The kit according to any one of claims 53 - 59 , wherein the OX40 agonist is PF-04518600.