Crystalline forms and salt forms of a kinase inhibitor

Inventors: Frenel DeMorin (Long Beach, CA); Khalid Shah (Half Moon Bay, CA); Sagar Shakya (San Diego, CA); Peter Wong (Brisbane, CA); Courtney S. Johnson (West Lafayette, IN); Melanie Janelle Bevill (West Lafayette, IN); Stephan D. Parent (West Lafayette, IN)

Assignee: Exelixis, Inc.

C07D215/48 C07B2200/13

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Quick Facts

Patent No.: US 12,017,995
App. No.: 17/312,658
Granted: Jun 25, 2024
Kind: B2

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Abstract

The present invention relates to crystalline forms of the free base of the c-Met inhibitor, Compound 1. The invention also relates to crystalline forms of salts of Compound 1. The invention also relates to pharmaceutical compositions comprising the solid polymorphs of the free base and salts of Compound 1. The invention further relates to methods of treating a disease, disorder, or syndrome mediated at least in part by modulating in vivo activity of a protein kinase.

Claims (2)

1. A crystalline hemifumarate salt of Compound 1 having the structure

2. A pharmaceutical composition comprising the crystalline hemifumarate salt of Compound 1 according to claim 1 and a pharmaceutically acceptable excipient.

Assignments (3)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 11, 2022

From: AMRI/SSCI, LLC

To: EXELIXIS, INC.

Reel/Frame 058990/0622 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 11, 2022

From: JOHNSON, COURTNEY S.; BEVILL, MELANIE JANELLE; PARENT, STEPHAN D.

To: AMRI/SSCI, LLC

Reel/Frame 058990/0755 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 11, 2022

From: DEMORIN, FRENEL; SHAH, KHALID; SHAKYA, SAGAR; WONG, PETER

To: EXELIXIS, INC.