Granted Patent
B2
US 12,350,261 · App. 17/314,272 · Granted Jul 8, 2025
Methods and devices for the treatment of ocular diseases in human subjects
Inventors:
Vladimir Zarnitsyn (Atlanta, GA); Samirkumar Patel (Atlanta, GA); Daniel White (Suwanee, GA); Glenn Noronha (Atlanta, GA); Brian Burke (Cary, NC)
Assignee:
Clearside Biomedical, Inc.
A61K31/4439A61K9/0019A61K9/0048A61K9/10A61K9/16A61K31/573A61K45/06A61K47/12A61K47/26A61K47/38A61M37/0015C07K16/22A61K2039/505A61K2039/54A61K2300/00A61M2037/0023A61M2037/0061
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Abstract
Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.
Claims (23)
1. A method of treating macular edema or age-related macular degeneration (AMD) in a human subject in need thereof, comprising, non-surgically administering an effective amount of a drug formulation comprising dexamethasone to the suprachoroidal space (SCS) of the eye of the human subject via a microneedle, wherein the human subject was previously treated with an anti-inflammatory drug.
2. The method of claim 1 , wherein the macular edema is diabetic macular edema (DME).
3. The method of claim 1 , wherein the human subject has AMD.
4. The method of claim 3 , wherein the AMD is dry AMD.
5. The method of claim 1 , wherein upon administration of the drug formulation to the SCS, the drug formulation flows away from the insertion site and is substantially localized to the posterior segment of the eye.
6. The method of claim 1 , wherein a dosage or volume of the drug formulation-sufficient to elicit a therapeutic response when administered to the SCS is less than the dosage or volume of the drug formulation sufficient to elicit a therapeutic response when administered intravitreally, intracamerally, topically, parenterally or orally.
7. The method of claim 1 , wherein the administering results in decreased ocular inflammation.
8. The method of claim 1 , wherein the microneedle is inserted into the sclera without penetrating across the sclera.
9. The method of claim 1 , wherein the microneedle is inserted into the sclera without penetrating through the choroid.
10. The method of claim 1 , wherein the non-surgically administering includes conveying the effective amount of the drug formulation to the SCS via a microneedle having a length of from about 500 μm to about 1500 μm.
11. The method of claim 1 , wherein the drug formulation comprises a suspension of microparticles or nanoparticles.
12. The method of claim 11 , wherein the microparticles have a D 50 of 2 μm or less.
13. The method of claim 1 , wherein the administering comprises positioning the needle perpendicular, or at an angle from about 80° to about 100° to the ocular surface of the eye.
14. The method of claim 1 , wherein the administration provides extended release of the drug.
15. The method of claim 1 , wherein the administering of the drug formulation to the SCS is monitored by an image-guided feedback method.
16. The method of claim 1 , the effective amount of the drug formulation is present in a volume of about 10 μL to about 200 μL.
17. The method of claim 16 , wherein the effective amount of the drug formulation is present in a volume of about 50 μL to about 150 μL.
18. The method of claim 1 , wherein the anti-inflammatory drug is a VEGF antagonist.
19. The method of claim 18 , wherein the VEGF antagonist is an anti-VEGF antibody.
20. The method of claim 19 , wherein the anti-VEGF antibody is selected from the group consisting of aflibercept, bevacizumab, ranibizumab, vandetanib, cabozantinib, ponatinib, ziv-aflibercept, lapatinib, sunitinib, sorafenib, plitidepsin, regorafenib, verteporfin, bucillamine, axitinib, pazopanib, fluocinolone acetonide, nintedanib, AL8326, 2C3 antibody, AT001 antibody, XtendVEGF antibody, HuMax-VEGF antibody, R3 antibody, AT001/r84 antibody, HyBEV, ANG3070, APX003 antibody, APX004 antibody, ponatinib, BDM-E, VGX100 antibody, VGX200, VGX300, COSMIX, DLX903/1008 antibody, ENMD2076, INDUS815C, R84 antibody, KD019, NM3, MGCD265, MG516, MP0260, NT503, anti-DLL4/VEGF bispecific antibody, PAN90806, Palomid 529, BD0801 antibody, XV615, lucitanib, motesanib diphosphate, AAV2-sFLT01, soluble Flt1 receptor, cediranib, AV-951, Volasertib, CEP11981, KH903, lenvatinib, lenvatinib mesylate, terameprocol, PF00337210,PRS050, SP01, carboxyamidotriazole orotate, hydroxychloroquine, linifanib, ALG1001,AGN150998, MP0112, AMG386, AVA101, BMS690514, KH902, golvatinib (E7050), dovitinib lactate (TKI258, CHIR258), ORA101, ORA102, Axitinib, PTC299, pegaptanib sodium, troponin, EG3306, vatalanib, Bmab 100, GSK2136773, Anti-VEGFR Alterase, Avila, CEP7055, CLT009, ESBA903, GW654652, HMPL010, GEM220, HYB676, JNJ17029259, TAK593, Nova21012, Nova21013, CP564959, AG028262, AG13958, CVX241, SU14813, PRS055, PG501, PG545, PTI101, TG100948, ICS283, XL647, enzastaurin hydrochloride, BC194, COT601M06.1, COT604M06.2, Mabion VEGF, Apatinib and AL3818.
21. The method of claim 1 , wherein the anti-inflammatory drug is a steroid.
22. The method of claim 1 , wherein the human patient was not properly responsive to the previous treatment.
23. The method of claim 1 , wherein the microneedle comprises a microcannula.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 6, 2022
From: ZARNITSYN, VLADIMIR; PATEL, SAMIRKUMAR; WHITE, DANIEL; NORONHA, GLENN; BURKE, BRIAN
To: CLEARSIDE BIOMEDICAL, INC.
Reel/Frame 061990/0251 →
Continuity (13)
Continuation
14441151
Provisional Application
61898926
· Nov 1, 2013
Provisional Application
61873660
· Sep 4, 2013
Provisional Application
61819388
· May 3, 2013
Provisional Application
61785229
· Mar 14, 2013
Provisional Application
61773124
· Mar 5, 2013
Provisional Application
61745237
· Dec 21, 2012
Provisional Application
61734872
· Dec 7, 2012
Provisional Application
61724144
· Nov 8, 2012
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