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App. No. 17/314,909 · Confirmation No. 3269

AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENT COMPOSITIONS AND METHODS OF USE THEREOF

Inventors: Stuart Milstein, Kirk Brown, Jayaprakash Nair, Martin Maier, Vasant Jadhav, Mark Keating, Adam Castoreno, Patrick Haslett, Mangala Meenakshi Soundarapandian, Kevin Fitzgerald

Applicant: ALNYLAM PHARMACEUTICALS, INC.

Docketed New Case - Ready for Examination View Publication ↗

	Code	Description	Pages	PDF
2026-06-05	`N417.PYMT`	Electronic Fee Payment	2	View
2026-06-05	`DIST.E.FILE`	Terminal Disclaimer-Filed (Electronic)	3	View
2026-06-05	`DISQ.E.FILE`	Terminal Disclaimer-Electronic-Approved	1	View
2026-06-05	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2026-06-05	`A.NE`	Response After Final Action	—	View
2026-06-05	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	5	View
2026-06-05	`RCEX`	Request for Continued Examination (RCE)	3	View
2026-06-05	`AMSB`	Amendment Submitted/Entered with Filing of Continued Prosecution Application (CPA)/Request for Continued Examination(RCE)	1	View
2026-06-05	`CLM`	Claims	7	View
2026-06-05	`REM`	Applicant Arguments/Remarks Made in an Amendment	7	View
2026-06-05	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2026-06-05	`N417.PYMT`	Electronic Fee Payment	2	View
2026-03-10	`CTFR`	Final Rejection	8	View
2026-03-10	`SRFW`	Search information including classification, databases and other search related notes	2	View
2026-03-10	`1449`	List of References cited by applicant and considered by examiner	5	View
2026-02-13	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	—	View
2026-02-13	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	5	View
2026-02-13	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	1	View
2026-02-13	`CLM`	Claims	6	View
2026-02-13	`REM`	Applicant Arguments/Remarks Made in an Amendment	7	View
2026-02-13	`REF.OTHER`	Other reference-Patent/Application/Search Documents	10	View
2026-02-13	`REF.OTHER`	Other reference-Patent/Application/Search Documents	4	View
2026-02-13	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2026-02-13	`N417.PYMT`	Electronic Fee Payment	2	View
2025-11-13	`CTNF`	Non-Final Rejection	11	View
2025-11-13	`SRFW`	Search information including classification, databases and other search related notes	2	View
2025-11-13	`1449`	List of References cited by applicant and considered by examiner	6	View
2025-11-13	`SRNT`	Examiner's search strategy and results	2	View
2025-08-14	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	—	View
2025-08-14	`REF.OTHER`	Other reference-Patent/Application/Search Documents	25	View
2025-08-14	`FOR`	Foreign Reference	64	View
2025-08-14	`REF.OTHER`	Other reference-Patent/Application/Search Documents	5	View
2025-08-14	`N417`	Electronic Filing System Acknowledgment Receipt	5	View
2025-08-14	`N417.PYMT`	Electronic Fee Payment	2	View
2025-08-14	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	1	View
2025-08-14	`SPEC`	Specification	2	View
2025-08-14	`CLM`	Claims	6	View
2025-08-14	`REM`	Applicant Arguments/Remarks Made in an Amendment	6	View
2025-08-14	`REF.OTHER`	Other reference-Patent/Application/Search Documents	6	View
2025-08-14	`REF.OTHER`	Other reference-Patent/Application/Search Documents	50	View
2025-08-14	`FOR`	Foreign Reference	199	View
2025-08-14	`REF.OTHER`	Other reference-Patent/Application/Search Documents	12	View
2025-08-14	`REF.OTHER`	Other reference-Patent/Application/Search Documents	3	View
2025-08-14	`FOR`	Foreign Reference	88	View
2025-08-14	`REF.OTHER`	Other reference-Patent/Application/Search Documents	10	View
2025-08-14	`REF.OTHER`	Other reference-Patent/Application/Search Documents	16	View
2025-08-14	`REF.OTHER`	Other reference-Patent/Application/Search Documents	4	View
2025-08-14	`REF.OTHER`	Other reference-Patent/Application/Search Documents	22	View
2025-08-14	`REF.OTHER`	Other reference-Patent/Application/Search Documents	4	View
2025-08-14	`REF.OTHER`	Other reference-Patent/Application/Search Documents	8	View
2025-08-14	`REF.OTHER`	Other reference-Patent/Application/Search Documents	13	View
2025-08-14	`TRAN.LET`	Transmittal Letter	1	View
2025-08-14	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	6	View
2025-08-14	`REF.OTHER`	Other reference-Patent/Application/Search Documents	5	View
2025-05-14	`CTNF`	Non-Final Rejection	12	View
2025-05-14	`892`	List of references cited by examiner	1	View
2025-05-14	`SRFW`	Search information including classification, databases and other search related notes	2	View
2025-05-14	`SRNT`	Examiner's search strategy and results	2	View
2025-05-14	`1449`	List of References cited by applicant and considered by examiner	5	View
2025-01-24	`CRFE`	Sequence Listing in Computer Readable Format, No errors found	—	View
2025-01-24	`CRFE`	Sequence Listing in Computer Readable Format, No errors found	16	View
2025-01-23	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	—	View
2025-01-23	`CLM`	Claims	6	View
2025-01-23	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	1	View
2025-01-23	`REM`	Applicant Arguments/Remarks Made in an Amendment	6	View
2025-01-23	`IDS.R197.REL`	Letter specifying the conditions for filing under 37 CFR 1.97	1	View
2025-01-23	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	5	View
2025-01-23	`SPEC`	Specification	332	View
2025-01-23	`REM`	Applicant Arguments/Remarks Made in an Amendment	329	View
2025-01-23	`FOR`	Foreign Reference	260	View
2025-01-23	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2025-01-23	`N417.PYMT`	Electronic Fee Payment	2	View
2025-01-23	`SEQ.TXT`	Sequence Listing (Text File)	1	View
2025-01-23	`136A`	Authorization for Extension of Time all replies	1	View
2024-09-23	`CTNF`	Non-Final Rejection	14	View
2024-09-23	`892`	List of references cited by examiner	1	View
2024-09-23	`SRFW`	Search information including classification, databases and other search related notes	2	View
2024-09-23	`1449`	List of References cited by applicant and considered by examiner	1	View
2024-09-23	`1449`	List of References cited by applicant and considered by examiner	1	View
2024-08-08	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2024-08-08	`TRAN.LET`	Transmittal Letter	1	View
2024-08-08	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	1	View
2024-05-22	`RCEX`	Request for Continued Examination (RCE)	3	View
2024-05-22	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2024-05-22	`N417.PYMT`	Electronic Fee Payment	2	View
2024-05-16	`CTAV`	Advisory Action (PTOL-303)	3	View
2024-05-16	`A.NE.AFCP.D`	After Final Consideration Program Decision	1	View
2024-05-03	`A.NE`	Response After Final Action	—	View
2024-05-03	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	1	View
2024-05-03	`N417.PYMT`	Electronic Fee Payment	2	View
2024-05-03	`A.NE.AFCP`	After Final Consideration Program Request	1	View
2024-05-03	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2024-05-03	`TRAN.LET`	Transmittal Letter	1	View
2024-05-03	`A.NE`	Response After Final Action	1	View
2024-05-03	`CLM`	Claims	6	View
2024-05-03	`REM`	Applicant Arguments/Remarks Made in an Amendment	4	View
2024-05-03	`WFEE`	Fee Worksheet (SB06)	1	View
2024-02-22	`CTFR`	Final Rejection	11	View
2024-02-22	`892`	List of references cited by examiner	1	View
2024-02-22	`SRFW`	Search information including classification, databases and other search related notes	2	View
2024-02-22	`1449`	List of References cited by applicant and considered by examiner	4	View
2024-02-22	`1449`	List of References cited by applicant and considered by examiner	1	View
2024-01-29	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2024-01-29	`N417.PYMT`	Electronic Fee Payment	2	View
2024-01-29	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	—	View
2024-01-29	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	1	View
2024-01-29	`CLM`	Claims	7	View
2024-01-29	`REM`	Applicant Arguments/Remarks Made in an Amendment	5	View
2024-01-29	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	1	View
2024-01-29	`TRAN.LET`	Transmittal Letter	1	View
2024-01-29	`N417.PYMT`	Electronic Fee Payment	2	View
2024-01-29	`N417`	Electronic Filing System Acknowledgment Receipt	4	View
2024-01-29	`N417.PYMT`	Electronic Fee Payment	2	View
2024-01-29	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2024-01-29	`DISQ.E.FILE`	Terminal Disclaimer-Electronic-Approved	1	View
2024-01-29	`DIST.E.FILE`	Terminal Disclaimer-Filed (Electronic)	3	View
2024-01-29	`WFEE`	Fee Worksheet (SB06)	1	View
2023-12-22	`N570`	Communication - Re: Power of Attorney (PTOL-308)	1	View
2023-12-22	`N570`	Communication - Re: Power of Attorney (PTOL-308)	1	View
2023-12-18	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2023-12-18	`PA..`	Power of Attorney	1	View
2023-12-18	`R3.73`	Assignee showing of ownership per 37 CFR 3.73	2	View
2023-11-10	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2023-11-10	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2023-09-27	`CTNF`	Non-Final Rejection	13	View
2023-09-27	`892`	List of references cited by examiner	1	View
2023-09-27	`SRFW`	Search information including classification, databases and other search related notes	1	View
2023-09-27	`1449`	List of References cited by applicant and considered by examiner	5	View
2023-09-27	`FOR`	Foreign Reference	69	View
2023-09-27	`1449`	List of References cited by applicant and considered by examiner	5	View
2023-09-27	`1449`	List of References cited by applicant and considered by examiner	4	View
2023-09-27	`SRNT`	Examiner's search strategy and results	1	View
2023-09-27	`1449`	List of References cited by applicant and considered by examiner	4	View
2023-09-27	`SRNT`	Examiner's search strategy and results	3	View
2023-09-27	`1449`	List of References cited by applicant and considered by examiner	4	View
2023-09-21	`FOR`	Foreign Reference	158	View
2023-09-21	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2023-09-21	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2023-09-13	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2023-09-13	`ELC.`	Response to Election / Restriction Filed	1	View
2023-09-13	`CLM`	Claims	5	View
2023-09-13	`REM`	Applicant Arguments/Remarks Made in an Amendment	2	View
2023-09-13	`WFEE`	Fee Worksheet (SB06)	1	View
2023-09-08	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2023-09-08	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2023-07-13	`CTRS`	Requirement for Restriction/Election	8	View
2023-06-21	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2023-06-21	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2023-06-21	`FOR`	Foreign Reference	193	View
2023-04-13	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2023-04-13	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2023-03-07	`N570`	Communication - Re: Power of Attorney (PTOL-308)	1	View
2023-03-02	`MFEE.C.AD.PC`	Change of Address via Patent Center	1	View
2023-03-02	`C.AD.PC`	Change of Address via Patent Center	1	View
2023-02-28	`PA..`	Power of Attorney	2	View
2023-02-28	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2023-01-05	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	5	View
2023-01-05	`FOR`	Foreign Reference	271	View
2023-01-05	`FOR`	Foreign Reference	236	View
2023-01-05	`FOR`	Foreign Reference	233	View
2023-01-05	`FOR`	Foreign Reference	320	View
2023-01-05	`FOR`	Foreign Reference	134	View
2023-01-05	`N417`	Electronic Filing System Acknowledgment Receipt	4	View
2022-01-06	`NTC.PUB`	Notice of Publication	1	View
2021-09-23	`WFEE`	Fee Worksheet (SB06)	1	View
2021-09-23	`APP.FILE.REC`	Filing Receipt	4	View
2021-09-22	`WFEE`	Fee Worksheet (SB06)	1	View
2021-09-20	`WFEE`	Fee Worksheet (SB06)	2	View
2021-09-20	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2021-09-20	`WFEE`	Fee Worksheet (SB06)	2	View
2021-09-20	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2021-09-18	`WFEE`	Fee Worksheet (SB06)	2	View
2021-09-18	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2021-09-17	`WFEE`	Fee Worksheet (SB06)	2	View
2021-09-17	`N417`	Electronic Filing System Acknowledgment Receipt	4	View
2021-09-17	`XT/`	Extension of Time	2	View
2021-09-17	`PEFR`	Applicant Response to Pre-Exam Formalities Notice	1	View
2021-09-17	`CLM`	Claims	6	View
2021-09-17	`REM`	Applicant Arguments/Remarks Made in an Amendment	1	View
2021-09-17	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	5	View
2021-09-17	`FOR`	Foreign Reference	62	View
2021-09-17	`REF.OTHER`	Other reference-Patent/Application/Search Documents	22	View
2021-09-17	`REF.OTHER`	Other reference-Patent/Application/Search Documents	15	View
2021-09-17	`FOR`	Foreign Reference	234	View
2021-09-17	`WFEE`	Fee Worksheet (SB06)	2	View
2021-09-17	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2021-05-24	`WCLM`	Claims Worksheet (PTO-2022)	2	View
2021-05-24	`WFEE`	Fee Worksheet (SB06)	1	View
2021-05-21	`NTC.MISS.PRT`	Notice to File Missing Parts	2	View
2021-05-21	`APP.FILE.REC`	Filing Receipt	4	View
2021-05-10	`CRFE`	Sequence Listing in Computer Readable Format, No errors found	12	View
2021-05-07	`SCORE`	Placeholder sheet indicating presence of supplemental content in Supplemental Complex Repository for Examiners(SCORE)	1	View
2021-05-07	`SEQ.TXT`	Sequence Listing (Text File)	1	View
2021-05-07	`CRFS`	CRF Statement that Sequence Listing text file (CRF) and paper/pdf Sequence Listing are the same	1	View
2021-05-07	`OATH`	Oath or Declaration filed	10	View
2021-05-07	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2021-05-07	`ADS`	Application Data Sheet	12	View
2021-05-07	`SPEC`	Specification	328	View
2021-05-07	`CLM`	Claims	33	View
2021-05-07	`ABST`	Abstract	1	View
2021-05-07	`DRW.NONBW`	Drawings-other than black and white line drawings	43	View
2021-05-07	`DRW.SUPP`	Drawings-black and white line and/or other drawings	—	View

Inventors

Stuart Milstein Cambridge, MA

Kirk Brown Cambridge, MA

Jayaprakash Nair Cambridge, MA

Martin Maier Cambridge, MA

Vasant Jadhav Cambridge, MA

Mark Keating Cambridge, MA

Adam Castoreno Cambridge, MA

Patrick Haslett Cambridge, MA

Mangala Meenakshi Soundarapandian Cambridge, MA

Kevin Fitzgerald Cambridge, MA

Attorneys & Agents of Record

SEIKO OKADA Reg. 78833 Attorney · WOMBLE BOND DICKSON (US) LLP

SARAH FENDRICK Reg. 66262 Attorney · ALNYLAM PHARMACEUTICALS

RACHEL YUNCK Reg. 78521 Agent · SAREPTA THERAPEUTICS, INC.

JULIE MEIGS Reg. 47447 Attorney · WOMBLE BOND DICKINSON LLP

DANA MAHADEO Reg. 73992 Attorney · ALNYLAM PHARMACEUTICALS INC.

CHRISTOPHER HUMPHREY Reg. 43683 Attorney · WOMBLE BOND DICKINSON (US) LLP

DENISE RAY Reg. 69142 Agent · WOMBLE BOND DICKINSON (US) LLP

Classification

USPC 514/44A

C12N15/113 A61P25/28 A61K9/0085 A61K31/713 A61K48/005 C07K14/4711 C12N2310/11 C12N2310/14 C12N2310/31 C12N2310/315 C12N2310/3183 C12N2310/321 C12N2310/322 C12N2310/3515 C12N2310/3521 C12N2310/3533 C12N2750/14143

Prosecution

Examiner: SHIN, DANA H
Art Unit: 1635
Customer No.: 168188
Docket No.: A108868 1740US.C2 (489.6)
Confirmation No.: 3269

Publication

Pub. No.: US20220002724A1
Pub. Date: 2022-01-06

Parent is a Continuation of

→

App. 16/925,286 · US 11,034,957

Filed 2020-07-09 · Patented Case

Parent PCT is a Continuation of

→

PCT/US2019/067449

Filed 2019-12-19 · Docketed New Case - Ready for Examination

Parent Claims priority from a provisional application

→

App. 62/928,795

Filed 2019-10-31 · Provisional Application Expired

Parent Claims priority from a provisional application

→

App. 62/862,472

Filed 2019-06-17 · Provisional Application Expired

Parent Claims priority from a provisional application

→

App. 62/781,774

Filed 2018-12-19 · Provisional Application Expired

BANK OF AMERICA, N.A.

from ALNYLAM PHARMACEUTICALS, INC., SIRNA THERAPEUTICS, INC.

SECURITY INTEREST Recorded 2025-10-01

072996/0337 →

ALNYLAM PHARMACEUTICALS, INC.

from CASTORENO, ADAM, JADHAV, VASANT, KEATING, MARK, MILSTEIN, STUART, MAIER, MARTIN, FITZGERALD, KEVIN, BROWN, KIRK, HASLETT, PATRICK, SOUNDARAPANDIAN, MANGALA MEENAKSHI, NAIR, JAYAPRAKASH

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded 2021-07-29

057022/0442 →

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Quick Facts

App. No.: 17/314,909
Filed: 2021-05-07
Pub. No.: US20220002724A1
Examiner: SHIN, DANA H
Art Unit: 1635

External Links

USPTO Patent Center↗ Pre-Grant Publication PDF↗