Cast-moldable, high refractive index, rigid, gas permeable polymer formulations for an accommodating contact lens
An eye-mountable device is provided that includes a plurality of rigid polymer layers separated by liquid crystal layers. Certain eye-mountable devices includes a first rigid polymer layer, a second rigid polymer layer, and a liquid crystal layer between the first and second rigid polymer layers. The liquid crystal layer has a refractive index that is electrically controllable between an ordinary refractive index and an extraordinary refractive index, and the first rigid polymer layer and second rigid polymer layer include materials having a refractive index similar to the ordinary refractive index of the liquid crystal layer. The first rigid polymer layer and second rigid polymer layer may also include a combination of monomer-derived units that provide cast-moldable materials with high oxygen permeability. Methods for fabricating the eye-mountable device and for changing the focal length of the eye-mountable device are also provided.
1. An eye-mountable device, comprising
a first rigid polymer layer having a first-layer refractive index;
a second rigid polymer layer having a second-layer refractive index; and
a first liquid crystal layer between the first and second rigid polymer layers, wherein the first liquid crystal layer has an ordinary refractive index and an extraordinary refractive index,
wherein
the first-layer refractive index and the second-layer refractive index differ by less than 0.01,
the ordinary refractive index and the extraordinary refractive index differ by more than 0.1,
the first-layer refractive index differs from either the ordinary refractive index or the extraordinary refractive index by less than 0.01, and
the first rigid polymer layer or second rigid polymer layer comprise:
one or more di(meth)acrylate-derived monomeric unit, wherein the one or more di(meth)acrylate-derived monomeric unit comprises diphenyl methacrylate; and
one or more (meth)acrylate-derived monomeric units, wherein the one or more (meth)acrylate-derived monomeric units comprise phenyl methacrylate.
2. The eye-mountable device of claim 1 , wherein the first-layer refractive index differs from the ordinary refractive index by less than 0.01.
3. The eye-mountable device of claim 2 , wherein the first-layer refractive index differs from the ordinary refractive index by less than 0.005.
4. The eye-mountable device of claim 2 , wherein the first-layer refractive index differs from the ordinary refractive index by less than 0.001.
5. The eye-mountable device of claim 2 , wherein the first-layer refractive index, second-layer refractive index and ordinary refractive index are between 1.55 and 1.80.
6. The eye-mountable device of claim 2 , wherein the first-layer refractive index, second-layer refractive index and ordinary refractive index are between 1.40 and 1.55.
7. The eye-mountable device of claim 1 , wherein the first-layer refractive index differs from the extraordinary refractive index by less than 0.01.
8. The eye-mountable device of claim 7 , wherein the first-layer refractive index differs from the extraordinary refractive index by less than 0.005.
9. The eye-mountable device of claim 7 , wherein the first-layer refractive index, second-layer refractive index and extraordinary refractive index are between 1.40 and 1.55.
10. The eye-mountable device of claim 7 , wherein the first-layer refractive index, second-layer refractive index and extraordinary refractive index are between 1.55 and 1.80.
11. The eye-mountable device of claim 7 , wherein the first-layer refractive index differs from the extraordinary refractive index by less than 0.001.
12. The eye-mountable device of claim 1 , wherein the one or more di(meth)acrylate-derived monomeric units comprise a hydrophobic di(meth)acrylate-derived monomeric unit and a polydimethylsiloxane-containing di(meth)acrylate-derived monomeric unit.
13. The eye-mountable device of claim 1 , wherein the one or more (meth)acrylate-derived monomeric units comprise an alkyl methacrylate-derived monomeric unit, an alkylene oxide (meth)acrylate-derived monomeric unit, a fluorinated methacrylate-derived monomeric unit and a silicon-containing methacrylate-derived monomeric unit.
14. The eye-mountable device of claim 1 , wherein the first or second rigid polymer layer comprises 15 weight percent to 30 weight percent of one or more di(meth)acrylate-derived monomeric unit and 60 weight percent to 85 weight percent of one or more (meth)acrylate-derived monomeric units.
15. The eye-mountable device of claim 1 , wherein the first or second rigid polymer layer comprises 15 weight percent to 30 weight percent of one or more di(meth)acrylate-derived monomeric unit, 40 weight percent to 55 weight percent of one or more (meth)acrylate-derived monomeric units, and 20 weight percent to 30 weight percent of one or more fluorinated (meth)acrylate-derived monomeric units.
16. The eye-mountable device of claim 1 , wherein the first or second rigid polymer layer comprises 15 weight percent to 30 weight percent of one or more di(meth)acrylate-derived monomeric unit, 15 weight percent to 25 weight percent of one or more methacrylate-derived monomeric units, 25 weight percent to 30 weight percent of one or more acrylate-derived monomeric units, and 20 weight percent to 30 weight percent of one or more fluorinated (meth)acrylate-derived monomeric units.
17. The eye-mountable device of claim 1 , wherein the first or second rigid polymer layer comprises 15 weight percent to 30 weight percent of one or more di(meth)acrylate-derived monomeric unit, 5 weight percent to 15 weight percent of one or more alkyl methacrylate-derived monomeric units, 10 weight percent to 20 weight percent of one or more silicon-containing methacrylate-derived monomeric units, 25 weight percent to 30 weight percent of one or more acrylate-derived monomeric units and 20 weight percent to 30 weight percent of one or more fluorinated (meth)acrylate-derived monomeric units.
18. The eye-mountable device of claim 1 , wherein the first or second rigid polymer layer comprises 5 weight percent to 10 weight percent of a monomeric unit derived from Bisphenol A dimethacrylate, 10 weight percent to 20 weight percent of a monomeric unit derived from methacryloxypropyl terminated polydimethylsiloxane 8-14 cSt, 20 weight percent to 30 weight percent of a monomeric unit derived from 1,1,1,3,3,3-Hexafluoroisopropyl methacrylate, 7 weight percent to 12 weight percent of a monomeric unit derived from methyl methacrylate, 10 weight percent to 20 weight percent of a monomeric unit derived from 3-[Tris(trimethylsiloxy)silyl]propyl methacrylate and 27 weight percent to 33 weight percent of a monomeric unit derived from o-phenylphenol ethyl acrylate.
19. The eye-mountable device of claim 1 , wherein the first rigid polymer layer and second rigid polymer layer have a gas permeability of at least 100 Barrers.
20. The eye-mountable device of claim 1 , further comprising a third rigid polymer layer having a third-layer refractive index and a second liquid crystal layer between the second rigid polymer layer and the third rigid polymer layer, wherein
the second liquid crystal layer has an ordinary refractive index and an extraordinary refractive index,
the second-layer refractive index and the third-layer refractive index differ by less than 0.01,
the ordinary refractive index and the extraordinary refractive index of the second liquid crystal layer differ by more than 0.1, and
the first-layer refractive index differs from either the ordinary refractive index or the extraordinary refractive index by less than 0.01.
21. A method for making the eye-mountable device of claim 1 , the method comprising
forming a first monomer solution;
curing the first monomer solution to provide the first rigid polymer layer;
forming a second monomer solution;
curing the second monomer solution to provide the second rigid polymer layer; and
providing the first liquid crystal layer between the first rigid polymer layer and second rigid polymer layer.
22. The method of claim 21 , wherein curing the first monomer solution to provide the first rigid polymer layer comprises curing the first monomer in a cast mold.
23. The method of claim 21 , wherein curing the second monomer solution to provide the second rigid polymer layer comprises curing the second monomer in a cast mold.