Luminal grafts and methods of making and using the same
Luminal grafts and methods of making and using the same. An exemplary luminal graft of the present disclosure is configured as a generally tubular element configured for nerve cells to grow therethrough and comprises at least one sheet of biological tissue having elastin fibers and collagen fibers, with the elastin fibers being a dominant component thereof; and a plurality of microchannels formed on a surface of the at least one sheet of biological tissue, each of the microchannels extending longitudinally between a first end and a second end of the at least one sheet of biological tissue and configured to provide intraluminal structural guidance to nerve cells proliferating therethrough.
1. A hybrid luminal graft comprising a generally tubular element, the luminal graft comprising:
a first layer comprising one or more synthetic materials, the first layer defining an inner surface and an opposing outer surface;
a biological material applied to the inner surface of the first layer, the biological material having elastin fibers and collagen fibers, with the elastin fibers being a dominant component thereof, and wherein the biological material is selected from the group consisting of pulmonary visceral pleura, pulmonary ligament, a component harvested from pulmonary visceral pleura, and a component harvested from pulmonary ligament; and
a plurality of microchannels formed on a surface of the biological material, each of the microchannels extending longitudinally between a first end and a second end of the biological material and configured to provide intraluminal structural guidance to nerve cells proliferating therethrough;
wherein when the first layer is configured as a generally tubular element, the biological material is present within a defined lumen of the first layer.
2. The hybrid luminal graft of claim 1 , wherein the synthetic material is silicone.
3. The hybrid luminal graft of claim 1 , wherein the synthetic material is polytetrafluoroethylene.
4. The hybrid luminal graft of claim 1 , wherein the synthetic material is elastomer.
5. The hybrid luminal graft of claim 1 , wherein a biological glue is used to facilitate adherence of the biological material to the inner surface.
6. The hybrid luminal graft of claim 1 , wherein the biological material comprises glycocalyx.
7. The hybrid luminal graft of claim 1 , further comprising:
a second layer comprising one or more synthetic materials, the second layer positioned around a relative outside of the first layer.
8. The hybrid luminal graft of claim 7 , further comprising:
a third layer comprising one or more synthetic materials, the third layer positioned around a relative outside of the second layer.