Optimizing analyte sensor calibration

1. An apparatus for reducing a number of blood glucose measurements to calibrate a glucose sensor, comprising:

the glucose sensor having an in vivo portion configured to be positioned in contact with an interstitial fluid of a user and comprising a working electrode and a silver/silver chloride reference electrode;

a non-transitory memory; and

at least one processor communicatively coupled to the non-transitory memory and the glucose sensor and configured to:

store a calibration schedule in the non-transitory memory, wherein the calibration schedule comprises a plurality of scheduled calibration events for receiving scheduled blood glucose measurements to calibrate the glucose sensor;

upon receiving an unscheduled blood glucose measurement after a successful prior scheduled calibration event but before a next scheduled calibration event, provide a prompt to verify the unscheduled blood glucose measurement;

upon receiving a confirmation acknowledgment to the prompt to verify the unscheduled blood glucose measurement, perform an unscheduled calibration event using the unscheduled blood glucose measurement to calibrate the glucose sensor using the unscheduled blood glucose measurement;

determine if the unscheduled calibration event successfully calibrated the glucose sensor;

provide a notification if the unscheduled calibration event failed; and

update the calibration schedule to override or modify the next scheduled calibration event if the unscheduled calibration event was successful.

2. The apparatus of claim 1 , wherein to update the calibration schedule, the at least one processor is further configured to modify the next scheduled calibration event to be a fixed time period after the unscheduled calibration event.

3. The apparatus of claim 2 , wherein the fixed time period is the same as a time period between the successful prior scheduled calibration event and the next scheduled calibration event before modification of the next calibration event.

4. The apparatus of claim 1 , wherein to perform the unscheduled calibration event, the at least one processor is further configured to validate a calibration condition parameter associated with the calibration of the glucose sensor.

5. The apparatus of claim 4 , wherein to validate the calibration condition parameter associated with the calibration of the glucose sensor, the at least one processor is further configured to determine if the unscheduled blood glucose measurement is within an acceptable range.

6. The apparatus of claim 4 , wherein the calibration condition parameter comprises a glucose rate of change.

7. The apparatus of claim 1 , wherein the calibration schedule comprises a first predetermined calibration event scheduled 12 hours after a prior scheduled calibration event.

8. The apparatus of claim 7 , wherein the calibration schedule comprises a second predetermined calibration event scheduled 12 hours after the first scheduled predetermined calibration event.

9. The apparatus of claim 8 , wherein upon receiving the unscheduled blood glucose measurement after the first predetermined calibration event and before the second predetermined calibration event, the at least one processor is further configured to update the calibration schedule by modifying the second predetermined calibration event to be scheduled 12 hours after the unscheduled calibration event.

10. The apparatus of claim 8 , wherein the calibration schedule comprises a third predetermined calibration event scheduled 24 hours after the second scheduled predetermined calibration event.

11. The apparatus of claim 10 , wherein the calibration schedule comprises additional predetermined calibration events scheduled every 24 hours after the third scheduled predetermined calibration event.

12. The apparatus of claim 11 , wherein upon receiving the unscheduled blood glucose measurement after the first predetermined calibration event and before the second predetermined calibration event, the at least one processor is further configured to update the calibration schedule by modifying the second predetermined calibration event to be scheduled 12 hours after the unscheduled calibration event, the third predetermined calibration event to be scheduled 24 hours after the modified second predetermined calibration event, and the additional predetermined calibration events to be scheduled every 24 hours after the modified third scheduled predetermined calibration event.

13. The apparatus of claim 11 , wherein upon receiving the unscheduled blood glucose measurement after the second predetermined calibration event and before the third predetermined calibration event, the at least one processor is further configured to update the calibration schedule by modifying the third predetermined calibration event to be scheduled 24 hours after the unscheduled calibration event and the additional predetermined calibration events to be scheduled every 24 hours after the modified third scheduled predetermined calibration event.

14. The apparatus of claim 10 , wherein upon receiving the unscheduled blood glucose measurement after the first predetermined calibration event and before the second predetermined calibration event, the at least one processor is further configured to update the calibration schedule by modifying the second predetermined calibration event to be scheduled 12 hours after the unscheduled calibration event and the third predetermined calibration event to be scheduled 24 hours after the modified second predetermined calibration event.

15. The apparatus of claim 10 , wherein upon receiving the unscheduled blood glucose measurement after the second predetermined calibration event and before the third predetermined calibration event, the at least one processor is further configured to update the calibration schedule by modifying the third predetermined calibration event to be scheduled 24 hours after the unscheduled calibration event.

16. The apparatus of claim 1 , wherein the calibration schedule comprises a first predetermined calibration event scheduled 24 hours after a prior scheduled calibration event.

17. The apparatus of claim 16 , wherein the calibration schedule comprises a second predetermined calibration event scheduled 24 hours after the first scheduled predetermined calibration event.

18. The apparatus of claim 17 , wherein the calibration schedule comprises additional predetermined calibration events scheduled every 24 hours after the second scheduled predetermined calibration event.

19. The apparatus of claim 18 , wherein upon receiving the unscheduled blood glucose measurement after the first predetermined calibration event and before the second predetermined calibration event, the at least one processor is further configured to update the calibration schedule by modifying the second predetermined calibration event to be scheduled 24 hours after the unscheduled calibration event and the additional predetermined calibration events to be scheduled every 24 hours after the modified second scheduled predetermined calibration event.

20. The apparatus of claim 17 , wherein upon receiving the unscheduled blood glucose measurement after the first predetermined calibration event and before the second predetermined calibration event, the at least one processor is further configured to update the calibration schedule by modifying the second predetermined calibration event to be scheduled 24 hours after the unscheduled calibration event.

21. The apparatus of claim 1 , wherein the calibration schedule comprises a plurality of different time periods between the plurality of scheduled calibration events.

22. The apparatus of claim 1 , wherein the at least one processor is further configured to determine a validity of glucose sensor data from the glucose sensor.

23. The apparatus of claim 1 , wherein the unscheduled blood glucose measurement is determined via a blood glucose test strip.

24. The apparatus of claim 1 , wherein to calibrate the glucose sensor using the unscheduled blood glucose measurement, the at least one processor is further configured to:

change a parameter associated with the glucose sensor based on the unscheduled blood glucose measurement.

25. A method for reducing a number of blood glucose measurements to calibrate a glucose sensor, comprising:

storing, by at least one processor, a calibration schedule in a non-transitory memory, wherein the calibration schedule comprises a plurality of scheduled calibration events for receiving scheduled blood glucose measurements to calibrate the glucose sensor having an in vivo portion configured to be positioned in contact with an interstitial fluid of a user and comprising a working electrode and a silver/silver chloride reference electrode;

receiving, by the at least one processor, an unscheduled blood glucose measurement after a successful prior scheduled calibration event but before a next scheduled calibration event;

providing, by the at least one processor, a prompt to verify the unscheduled blood glucose measurement;

receiving, by the at least one processor, a confirmation acknowledgement to the prompt to verify the unscheduled blood glucose measurement, performing an unscheduled calibration event using the unscheduled blood glucose measurement, and calibrating the glucose sensor using the unscheduled blood glucose measurement;

determining, by the at least one processor, if the unscheduled calibration event successfully calibrated the glucose sensor;

providing, by the at least one processor, a notification if the unscheduled calibration event failed; and

updating, by the at least one processor, the calibration schedule to override or modify a next scheduled calibration event if the unscheduled calibration event was successful.

26. The method of claim 25 , wherein the updating the calibration schedule further comprises modifying the next scheduled calibration event to be a fixed time period after the unscheduled calibration event.

27. The method of claim 26 , wherein the fixed time period is the same as a time period between the successful prior scheduled calibration event and the next scheduled calibration event before modification.

28. The method of claim 25 , wherein performing the unscheduled calibration event further comprises validating a calibration condition parameter associated with the calibration of the glucose sensor.

29. The method of claim 28 , wherein the validating further comprises determining if the unscheduled blood glucose measurement is within an acceptable range.

30. The method of claim 28 , wherein the calibration condition parameter comprises a glucose rate of change.