Radiopaque polymers
Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.
1. A method of treatment in which a hydrogel is administered into a blood vessel of a patient to embolize said blood vessel, the hydrogel being in the form of microspheres comprising a cross-linked polymer network that comprises polyvinyl alcohol (PVA) or a copolymer of PVA and a radiopaque species comprising one or more covalently bound iodines that are coupled to the PVA or copolymer of PVA through a cyclic acetal group and that provides the microspheres with greater than 15 mg of iodine per ml of microspheres fully hydrated in normal saline as a packed volume wherein the radiopaque species comprises an iodinated aromatic group.
2. The method of claim 1 , wherein the blood vessel is associated with a solid tumor.
3. The method of claim 2 , wherein the solid tumor is hepatocellular carcinoma.
4. A method of treatment in which a composition is administered into a blood vessel of a patient to embolize said blood vessel, the composition comprising (a) hydrogel in the form of microspheres comprising a cross-linked polymer network that comprises polyvinyl alcohol (PVA) or a copolymer of PVA and a radiopaque species comprising one or more covalently bound iodines that are coupled to the PVA or copolymer of PVA through a cyclic acetal group and that provides the microspheres with greater than 15 mg of iodine per ml of microspheres fully hydrated in normal saline as a packed volume and (b) a therapeutic agent, wherein the therapeutic agent is absorbed into the microspheres wherein the radiopaque species comprises an iodinated aromatic group.
5. The method of claim 4 , wherein the blood vessel is associated with a solid tumor.
6. The method of claim 1 , wherein the radiopaque species provides the microspheres with greater than 50 mg of iodine per ml of microspheres fully hydrated in normal saline as a packed volume.
7. The method of claim 1 , wherein the radiopaque species provides the microspheres with greater than 100 mg of iodine per ml of microspheres fully hydrated in normal saline as a packed volume.
8. The method of claim 1 , wherein the hydrogel has a net charge at physiological pH.
9. The method of claim 1 , wherein the radiopaque species comprises an iodinated phenyl group.
10. The method of claim 1 , wherein the microspheres have a mean diameter size range of from 10 to 2000 m.
11. The method of claim 1 , wherein the microspheres have a mean radiopacity of 500HU or greater.
12. The method of claim 4 , wherein the microspheres have a mean diameter size range of from 10 to 2000 μm.
13. The method of claim 4 , wherein the microspheres have a mean radiopacity of 500HU or greater.
14. The method of claim 4 , wherein the hydrogel has a net charge at physiological pH.
15. The method of claim 14 , wherein the therapeutic agent is electrostatically held in the hydrogel and elutes from the hydrogel in electrolytic media.
16. The method of claim 4 , wherein the radiopaque species provides the microspheres with greater than 50 mg of iodine per ml of microspheres fully hydrated in normal saline as a packed volume.
17. The method of claim 4 , wherein the radiopaque species provides the microspheres with greater than 100 mg of iodine per ml of microspheres fully hydrated in normal saline as a packed volume.
18. A method of treatment in which a hydrogel is administered into a blood vessel of a patient to embolize said blood vessel, the hydrogel having a net charge at physiological pH in the form of microspheres having a mean diameter size range of from 10 to 2000 m and comprising a cross-linked polymer network that comprises polyvinyl alcohol (PVA) or a copolymer of PVA and a radiopaque species comprising an iodinated aromatic group that is coupled to the PVA or copolymer of PVA through a cyclic acetal group and that provides the microspheres with greater than 50 mg of iodine per ml of microspheres fully hydrated in normal saline as a packed volume.