EPINEPHRINE-BASED OPHTHALMIC COMPOSITIONS FOR INTRAOCULAR ADMINISTRATION AND METHODS FOR FABRICATING THEREOF

1 . A method of preventing intraoperative floppy iris syndrome, the method comprising administering to a patient an ophthalmic pharmaceutical composition consisting of:

(1) a therapeutically effective quantity of at least one compound selected from the group consisting of epinephrine, phenylephrine, EPI-Shugarcaine and tropicamide;

(2) at least one metal chelator, wherein the metal chelator is ethylenediaminetetraacetic acid or a pharmaceutically acceptable salt thereof;

(3) optionally, at least one anesthetic;

(4) optionally, at least one tonicity adjusting agent comprising sodium chloride;

(5) optionally, hydrochloric acid and/or sodium hydroxide;

(6) optionally, at least one non-steroid anti-inflammatory drug; and

(7) a quantity of sterile water,

wherein the composition is free of sulfites, is free of preservatives, and has a pH above 6.0 and below 8.0.

2 . The method of claim 1 , wherein the epinephrine is in the form of epinephrine hydrochloride.

3 . The method of claim 1 , wherein the pharmaceutically acceptable salt of ethylenediaminetetraacetic acid is disodium edetate.

4 . The method of claim 1 , wherein the at least one anesthetic is selected from the group consisting of lidocaine, proparacaine, procaine, tetracaine, and combinations thereof.

5 . The method of claim 1 , wherein the at least one non-steroid anti-inflammatory drug is selected from the group consisting of ketorolac, ketoprofen, flurbiprofen, bromfenac, diclofenac and combinations thereof.

6 . The method of claim 1 , wherein the ophthalmic pharmaceutical composition consists of tropicamide, phenylephrine HCl, ethylenediaminetetraacetic acid or a pharmaceutically acceptable salt thereof, lidocaine HCl, sodium chloride, hydrochloric acid, and/or sodium hydroxide, and sodium diclofenac in sterile water.