Methods and compositions for reversing or mitigating skin aging
A method for reversing or mitigating skin aging comprising topically applying a composition which comprises at least one oxidant, and at least one fluorescent dye capable of activating the oxidant and illuminating said composition for a time sufficient to activate the at least one oxidant.
1. A method for reversing or mitigating skin aging comprising:
a) topically applying on an area of a patient's skin to be treated a composition comprising at least one oxidant selected from at least one of hydrogen peroxide, carbamide peroxide and benzoyl peroxide, and at least one fluorescent dye selected from a xanthene derivative dye, an azo dye, a biological stain and a cartenoid, capable of activating the oxidant;
b) illuminating the applied composition with actinic light for a period of about 60 seconds to about 5 minutes per cm 2 of the area to be treated; thereby reversing or mitigating skin aging; and c) at least one healing factor selected from hyaluronic acid, glucosamine and allantoin.
2. The method according to claim 1 , wherein the actinic light has an emission wavelength of between about 400 nm and about 600 nm.
3. The method according to claim 1 , wherein the actinic light has a power density of between about 900 mW/cm 2 to about 2000 mW/cm 2 .
4. The method according to claim 1 , wherein the actinic light is in continuous motion over an area to be treated.
5. The method according to claim 1 , wherein the composition further comprises at least one hydrophilic gelling agent.
6. The method according to claim 5 , wherein the at least one hydrophilic gelling agent is selected from at least one of glucose, modified starch, methyl cellulose, carboxymethyl cellulose, propyl cellulose, hydroxypropyl cellulose, a carbomer polymer, alginic acid, sodium alginate, potassium alginate, ammonium alginate, calcium alginate, agar, carrageenan, locust bean gum, pectin and gelatin.
7. The method according to claim 1 , wherein the composition further comprises at least one chelating agent selected from ethylenediaminetetraacetic acid (EDTA) an ethylene glycol tetraacetic acid (EGTA).
8. The method according to claim 1 , wherein the composition further comprises at least one of rhodamine B, rhodamine WT, rhodamine G, phloxine B, rose bengal, eosin B, fluorescein, Erythrosine B, saffranin O, basic fuchsine, acid fuchsine, 3,3′-dihexylocarbocyanine iodide, carminic acid, indocyanine green, crocetin, alpha-crocin (8,8-diapo-8,8-carotenoic acid), zeaxanthine, lycopene, alpha-carotene, beta-carotene, merbromine, bixin, fucoxanthine, methyl violet, neutral red, para red, amaranth, carmoisine, allura red AC, tartrazine, orange G, ponceau 4R, methyl red, murexide-ammonium purpurate, pyronine Y and pyronine B.
9. The method according to claim 1 , wherein the composition further comprises at least one lipolysis stimulating factor selected from caffeine and paraxanthine.