METAL DI-AMINO ACID CHELATES OR METAL TRI-AMINO ACID CHELATES
The present disclosure relates to metal di-amino acid chelates and metal tri-amino acid chelates.
1 . A composition comprising a magnesium di-amino acid chelate complex, the complex comprising a magnesium di-amino acid chelate and a counterion, wherein there is a 1:1 ratio between the magnesium and the di-amino acid.
2 . The composition of claim 1 , wherein the di-amino acid is selected from the group consisting of di-glycine (G2), di-aspartic acid (D2), di-glutamic acid (E2), di-histidine (H2), di-serine (S2), and di-tyrosine (Y2).
3 . The composition of claim 1 , wherein each amino acid of the di-amino acid is selected from the group consisting of glycine (G), aspartic acid (D), glutamic acid (E), histidine (H), serine (S), and tyrosine (Y).
4 . The composition of claim 1 , wherein the di-amino acid is di-glycine.
5 . The composition of claim 1 , further comprising at least one vitamin or additional mineral.
6 . A composition comprising a zinc di-amino acid chelate complex, the complex comprising a zinc di-amino acid chelate and optionally a counterion, wherein there is a 1:1 or 1:2 ratio between the zinc and the di-amino acid.
7 . The composition of claim 6 , wherein the di-amino acid is selected from the group consisting of di-glycine (G2), di-aspartic acid (D2), di-glutamic acid (E2), di-histidine (H2), di-serine (S2), and di-tyrosine (Y2).
8 . The composition of claim 6 , wherein each amino acid of the di-amino acid is selected from the group consisting of glycine (G), aspartic acid (D), glutamic acid (E), histidine (H), serine (S), and tyrosine (Y).
9 . The composition of claim 6 , wherein the di-amino acid is di-glycine.
10 . The composition of claim 6 , further comprising at least one vitamin or additional mineral.
11 . A composition comprising a calcium di-amino acid chelate complex, the complex comprising a calcium di-amino acid chelate and optionally a counterion, wherein there is a 1:1 or 1:2 ratio between the calcium and the di-amino acid.
12 . The composition of claim 11 , wherein the di-amino acid is selected from the group consisting of di-glycine (G2), di-aspartic acid (D2), di-glutamic acid (E2), di-histidine (H2), di-serine (S2), and di-tyrosine (Y2).
13 . The composition of claim 11 , wherein each amino acid of the di-amino acid is selected from the group consisting of glycine (G), aspartic acid (D), glutamic acid (E), histidine (H), serine (S), and tyrosine (Y).
14 . The composition of claim 11 , wherein the di-amino acid is di-glycine.
15 . The composition of claim 11 , further comprising at least one vitamin or additional mineral.
16 . A pharmaceutical formulation, the formulation comprising the composition of any of claim 1 .
17 . The pharmaceutical formulation of claim 16 , wherein the formulation is suitable for oral administration.
18 . The pharmaceutical formulation of claim 16 , wherein the formulation is suitable for parenteral administration.
19 . A method of supplying a metal to a subject deficient in a metal, the method comprising administering the chelate of claim 1 to the subject.
20 . The method of claim 19 , wherein the metal is selected from the group consisting of magnesium, calcium, zinc, iron, and a mixture thereof.
21 . A method of producing a metal di-amino acid chelate complex, the method comprising
(i) creating an aqueous solution of a di-amino acid, a metal compound, and optionally an organic acid,
(ii) stirring the solution of step (i) while optionally heating up to 90° C. for a minimum of 10 min,
(iii) cooling the solution and precipitating the metal di-amino acid chelate complex.
22 . The method of claim 21 , the method comprising individually heating an aqueous solution of the di-amino acid and an aqueous solution of the metal compound and optionally organic acid before combining them to create the solution of step (i).
23 . A metal di-amino acid chelate complex formed by the method comprising
(i) creating an aqueous solution of a di-amino acid, a metal compound, and optionally an organic acid,
(ii) stirring the solution of step (i) while optionally heating the solution to less than 90° C. for a minimum of 10 min,
(iii) cooling the combination and precipitating the metal di-amino acid chelate complex.