IP Library › Granted Patent US 12,239,980
Granted Patent B2
US 12,239,980 · App. 17/336,377 · Granted Mar 4, 2025

Implementing barriers for controlled environments during sample processing and detection

Inventors: Nathan Beckett (Oakland, CA); Nathan Caswell (Sunnyvale, CA)
Assignee: Ultima Genomics, Inc.
B01L3/50273B01L3/502715G01N7/02
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Quick Facts
Patent No.
US 12,239,980
App. No.
17/336,377
Granted
Mar 4, 2025
Kind
B2
Abstract

Provided herein are methods for processing and/or detecting a sample. A method can comprise providing a barrier between a first region and a second region, wherein the first region comprises the sample, wherein the barrier maintains the first region at a first atmosphere that is different than a second atmosphere of the second region, wherein a portion of the barrier comprises a fluid in coherent motion; and using a detector at least partially contained in the first region to detect one or more signals from the sample while the first region is maintained at the first atmosphere that is different than the second atmosphere of the second region. The portion of the barrier comprising fluid may have a pressure lower than the first atmosphere, the second atmosphere, or both.

Claims (23)

1. A system for processing or analyzing an analyte, comprising: a chamber and a lid, wherein said chamber comprises an internal region and a substrate, wherein said analyte is immobilized adjacent to said substrate, wherein said lid is disposed adjacent to and not in mechanical contact with said chamber; and an environmental unit to maintain a first local environment and a second local environment within said internal region while said lid is not in mechanical contact with said chamber and during movement of said substrate within said chamber, wherein said environmental unit maintains (i) said first local environment at a first temperature or first temperature range, and (ii) said second local environment at a second temperature or second temperature range,

wherein said first local environment is disposed above said second local environment, and wherein said first local environment is at or in proximity to said lid,

wherein said second local environment is disposed at or near a surface of said substrate, and

wherein said first temperature or first temperature range is higher than said second temperature or second temperature range.

2. The system of claim 1 , wherein said environmental unit further maintains a third local environment within said internal region at a third temperature or third temperature range, wherein said third local environment is disposed below said first local environment and said second local environment.

3. The system of claim 2 , wherein said third temperature or third temperature range is lower than said first temperature or first temperature range and higher than said second temperature or second temperature range.

4. The system of claim 2 , wherein said third local environment is comprises a humidity source at or near a bottom of said internal region.

5. The system of claim 4 , wherein said humidity source comprises a body of liquid.

6. The system of claim 1 , wherein said environmental unit comprises one or more members selected from the group consisting of: a humidifier, dehumidifier, heater, heat exchanger, heating element, cooling element, and compressor.

7. The system of claim 1 , wherein said lid moves relative to said chamber, or vice versa.

8. The system of claim 1 , further comprising a fluid flow unit to provide fluid in bulk motion at a location disposed between said chamber and said lid.

9. The system of claim 8 , wherein said fluid in bulk motion provides a partial vacuum in said location disposed between said chamber and said lid.

10. The system of claim 8 , wherein said fluid in bulk motion generates negative pressure in said location disposed between said chamber and said lid.

11. The system of claim 8 , wherein said fluid flow unit uses fluid from said internal region, an external region that is external to said chamber, or both to provide said fluid in bulk motion.

12. The system of claim 8 , wherein said fluid comprises air.

13. The system of claim 8 , wherein said fluid flow unit maintains said internal region at a first humidity or first humidity range, wherein said first humidity or first humidity range is different than a second humidity or second humidity range of an external region that is external to said chamber.

14. The system of claim 13 , wherein said external region is at a room atmosphere or an ambient atmosphere.

15. The system of claim 13 , wherein said internal region has a relative humidity greater than 90%.

16. The system of claim 1 , further comprising a detection unit that is at least partially contained in said internal region.

17. The system of claim 16 , wherein a first portion of said detection unit comprises an optical imaging objective that is at least partially immersed in an immersion fluid in contact with said substrate in said internal region, and wherein a second portion of said detection unit is in an external region that is external to said chamber.

18. The system of claim 16 , wherein said detection unit is fixed relative to said lid.

19. The system of claim 1 , wherein said substrate is rotatable relative to said chamber.

20. The system of claim 1 , wherein said internal region comprises a third local environment at a bottom of said chamber, wherein said bottom of said chamber comprises a body of liquid that generates vapor, wherein said body of liquid is maintained at third temperature or third temperature range between said first temperature or temperature range and said second temperature or temperature range.

Assignments (3)
SECURITY INTEREST Recorded Apr 3, 2026
From: ULTIMA GENOMICS, INC.
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 075435/0595 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 30, 2021
From: BECKETT, NATHAN; CASWELL, NATHAN
To: ULTIMA GENOMICS, INC.
Reel/Frame 057325/0463 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 6, 2021
From: BECKETT, NATHAN; CASWELL, NATHAN
To: ULTIMA GENOMICS, INC.
Reel/Frame 057103/0275 →
Continuity (6)
Continuation PCTUS2019064916 · Dec 6, 2019
Continuation In Part 16665540 · Oct 28, 2019
Continuation In Part 16665559 · Oct 28, 2019
Continuation In Part 16440026 · Jun 13, 2019
Provisional Application 62776866 · Dec 7, 2018
Related Publication 20210354126A1 · Nov 18, 2021
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