IP Library Granted Patent US 11,717,244
Granted Patent B2
US 11,717,244 · App. 17/342,334 · Granted Aug 8, 2023

Methods for physiological state determination in body scans

Inventors: Kevin Wilson (Bedford, MA); Thomas Kelly (Bedford, MA)
Assignee: Hologic, Inc.
A61B6/482A61B6/405A61B6/50A61B6/5217A61B6/4035G06T7/0012
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Quick Facts
Patent No.
US 11,717,244
App. No.
17/342,334
Granted
Aug 8, 2023
Kind
B2
Abstract

A system for measuring muscle mass of a patient has a dual-energy radiation emission source. A radiation detector is configured to detect radiation emitted from the dual-energy radiation emission source passed through the patient. A processor has a memory with storing instructions, that when executed by the processor, perform a set of operations. The operations include receiving radiation detection data; generating a scan representation; identifying a primary fat target; determining an amount of fat in the primary fat target; comparing the amount of fat in the primary fat target to a reference; and based on the comparison, correcting an estimated amount of lean tissue to generate a corrected muscle mass value.

Claims (55)

1. A method for identifying a condition in a patient, the method comprising:

detecting, by a detector, a beam of radiation having passed through the patient;

based on the detected beam of radiation, generating a scan representation including one or more pixels;

identifying, by a processor, a primary fat target in the scan representation;

analyzing, by the processor, at least one pixel within the scan representation to determine a sum of an amount of fat and an amount of water in the primary fat target;

comparing, by the processor, the determined sum to a reference amount;

based on the comparison, generating, by the processor, a condition indicator; and

displaying the condition indicator on a user interface.

2. The method of claim 1 , wherein the condition indicator corresponds to a localized edema in a region of interest of the patient.

3. The method of claim 2 , wherein the condition indicator is displayed on a user interface operatively coupled to a densitometer.

4. The method of claim 1 , wherein the region of interest is an appendage.

5. The method of claim 1 , wherein the reference amount is determined from a set of sample persons.

6. The method of claim 1 , wherein the primary fat target is a subcutaneous fat region.

7. A method for identifying a condition in a subject, the method comprising:

irradiating the subject with a radiation from a radiation source;

detecting, by a radiation detector, a subject radiation from the subject in response to the irradiation;

generating a representation of a region of interest of the subject based on the detected radiation;

identifying, by a processor, a target tissue within the representation;

identifying, by the processor, a subregion in the representation as representative of the target tissue;

analyzing, by the processor, the subregion to determine a sum of an amount of fat and an amount of water in the target tissue;

comparing, by the processor, the determined sum of fat and water to a reference amount;

generating, by the processor, a condition indicator based on the comparison; and

displaying the condition indicator on a user interface.

8. The method of claim 7 , wherein detecting a radiation from the subject comprises detecting the radiation from the radiation source and passed through the subject.

9. The method of claim 7 , wherein:

irradiating the subject with a radiation from a radiation source comprises irradiating the subject with a scanned radiation;

generating a representation of a region of interest comprises generating a scan representation, having one or more pixels, of the region of interest;

identifying a subregion comprises identifying, by the processor, a pixel in the scan representation representative of the target tissue; and

analyzing the target tissue comprises analyzing the pixel to determine the sum of fat and water in the target tissue.

10. The method of claim 7 , wherein identifying a target tissue comprises identifying a primary fat target.

11. The method of claim 10 , wherein identifying a target tissue comprises identifying a portion of the body that is predominately not occupied by muscle.

12. The method of claim 7 , wherein generating a condition indicator comprises generating, by the processor, an indicator corresponding to localized edema.

13. The method of claim 7 , wherein displaying the condition indicator comprises displaying the condition indicator on a user interface operatively coupled to a densitometer.

14. The method of claim 7 , wherein the reference amount comprises an amount of fat and an amount of water determined from a set of sample subjects.

15. An apparatus, comprising:

one or more radiation sources configured to irradiate a subject with a radiation;

one or more radiation detectors configured to detect a subject radiation from the subject in response to the irradiation;

one or more processors; and

a memory coupled to the one or more processors and storing instructions that, when executed by the one or more processors, carry out a process comprising:

receive radiation detection data from the one or more radiation detectors;

generating a representation of a region of interest of the subject based on the radiation detection data;

identifying a target tissue within the representation;

identifying a subregion in the representation as representative of the target tissue;

analyzing the subregion to determine a sum of an amount of fat and an amount of water in the target tissue;

comparing the determined sum of fat and water to a reference amount; and

generating a condition indicator based on the comparison.

16. The apparatus of claim 15 , wherein identifying a target tissue comprises identifying a primary fat target.

17. The apparatus of claim 16 , where identifying a primary fat target comprises identifying a subcutaneous fat region.

18. The apparatus of claim 15 , wherein generating a condition indicator comprises generating an indicator corresponding to localized edema.

19. The apparatus of claim 15 , wherein:

the radiation source comprises a scanning radiation source;

generating a representation of a region of interest comprises generating a scan representation, having one or more pixels, of the region of interest;

identifying a subregion comprises identifying a pixel in the scan representation representative of the target tissue; and

analyzing the target tissue comprises analyzing the pixel to determine the sum of fat and water in the target tissue.

20. The apparatus of claim 15 , wherein the reference amount comprises an amount of fat and an amount of water determined from a set of sample subjects.

Assignments (3)
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
SECURITY INTEREST Recorded Oct 12, 2021
From: HOLOGIC, INC.; FAXITRON BIOPTICS, LLC; BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 057787/0526 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2021
From: WILSON, KEVIN E.; KELLY, THOMAS L.
To: HOLOGIC, INC.
Reel/Frame 057210/0123 →
Cited By (1)
US 12,329,563