Granted Patent
B2
US 12,636,074 · App. 17/349,299 · Granted May 26, 2026
Methods and apparatus for selective tissue ablation
Assignee:
Boston Scientific Scimed, Inc.
A61B18/1492A61B5/0538A61N1/327A61N7/022A61B2017/00026A61B2017/00154A61B2018/0022A61B2018/00267A61B2018/00351A61B2018/00404A61B2018/00577A61B2018/00613A61B2018/00654A61B2018/00827A61B2018/00839A61B2018/00875A61B2018/00892A61B2018/00994A61B2018/124A61B2018/1467A61B18/1815A61B2218/002A61B2576/023A61N1/0412
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Abstract
Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.
Claims (28)
1 . An apparatus, comprising:
a catheter shaft having a distal end portion including an outside and inner side of the catheter shaft;
an inflatable balloon coupled to the distal end portion, an outer surface of the balloon being an electrical insulator, the balloon having a wall and the wall of the balloon having a varying cross section;
a first electrode coupled to a proximal side of the balloon;
a second electrode coupled to a distal side of the balloon, the first and second electrode configured to generate an electric field for irreversible electroporation in target tissue adjacent to the balloon;
wherein the second electrode is disposed on the inner side of the catheter shaft and internally exposed;
an ultrasound transducer disposed within the ballon to deliver ultrasound energy in combination with the electric field; and
a voltage pulse generator configured to produce a pulsed voltage waveform operably coupled to the first and second electrodes and configured to apply the pulsed voltage waveform between the first and second electrodes to generate the electric field.
2 . The apparatus of claim 1 , wherein the first electrode is a cathode and the second electrode is an anode.
3 . The apparatus of claim 1 , wherein the balloon is configured to displace collateral anatomical structures when in an expanded configuration.
4 . The apparatus of claim 1 , wherein the ultrasound transducer is disposed on a portion of the catheter shaft inside the balloon, the balloon being inflatable with a liquid, with at least a portion of the wall of the balloon being filled with a gas, where the balloon is configured to reflect at least a portion of the ultrasound energy from the ultrasound transducer to a kinetic energy focusing zone in the target tissue to cause an increase in temperature.
5 . The apparatus of claim 1 , wherein the outer surface of the balloon is coated with a layer of insulative material.
6 . The apparatus of claim 5 , wherein the insulative material is aluminum oxide.
7 . The apparatus of claim 4 , wherein the kinetic energy focusing zone is annular in shape.
8 . A system for ablating target tissue by irreversible electroporation, the system comprising:
an ablation catheter comprising:
a catheter shaft having a distal end portion including an outside and inner side of the catheter shaft;
an inflatable balloon coupled to the distal end portion;
a first electrode coupled to a proximal side of the balloon;
a second electrode coupled to a distal side of the balloon, the second electrode disposed on the inner side of the catheter shaft and internally exposed, the first and second electrodes configured to generate an electric field for irreversible electroporation in the target tissue adjacent to the balloon; and
an ultrasound transducer disposed within the ballon to deliver ultrasound energy in combination with the electric field; and
a voltage pulse generator configured to produce a pulsed voltage waveform operably coupled to the first and second electrodes and configured to apply the pulsed voltage between the first and second electrodes to generate the electric field.
9 . The system of claim 8 , wherein an outer surface of the balloon is an electrical insulator.
10 . The system of claim 8 , wherein an outer surface of the balloon is coated with an electrically insulative material.
11 . The system of claim 10 , wherein the electrically insulative material is aluminum oxide.
12 . The system of claim 9 , wherein the first electrode is configured as a cathode, and the second electrode is configured as an anode.
13 . The system of claim 9 , wherein the ultrasound transducer is disposed on a portion of the catheter shaft inside the balloon, wherein at least a portion of a wall of the balloon is configured to reflect at least a portion of the ultrasound energy from the ultrasound transducer to define a kinetic energy focusing zone in the target tissue.
14 . The system of claim 13 , wherein an interior of the balloon is configured to receive an inflation liquid, and wherein at least the portion of the wall of the balloon is configured to be filled with a gas so as to define a liquid-gas interface at the wall of the balloon, the liquid-gas interface operable to reflect the ultrasound energy from the ultrasound transducer.
Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 21, 2022
From: FARAPULSE, INC.
To: BOSTON SCIENTIFIC SCIMED, INC.
Reel/Frame 060802/0286 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 16, 2021
From: MICKELSEN, STEVEN R.
To: IOWA APPROACH, INC.
Reel/Frame 056567/0603 →
CHANGE OF NAME
Recorded Jun 16, 2021
From: IOWA APPROACH, INC.
To: FARAPULSE, INC.
Reel/Frame 056611/0736 →
Continuity (5)
Continuation
PCTUS2015029734
· May 7, 2015
Provisional Application
61996390
· May 7, 2014
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