IP Library › Granted Patent US 12,227,549
Granted Patent B2
US 12,227,549 · App. 17/359,902 · Granted Feb 18, 2025

RNA encoding a therapeutic protein

Inventors: Mariola Fotin-Mleczek (Sindelfingen, DE); Ingmar Hoerr (Stuttgart, DE)
Assignee: CureVac SE
C07K14/505A61K31/7088A61K31/7105A61K45/06A61K48/005C12N15/113A61K38/00A61K48/00C12N2310/531
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Quick Facts
Patent No.
US 12,227,549
App. No.
17/359,902
Granted
Feb 18, 2025
Kind
B2
Abstract

The present invention relates to an RNA encoding a therapeutic protein. In particular, the present invention relates to RNA suitable for use as a medicament. The present invention concerns such novel RNA as well as compositions and kits comprising the RNA. Furthermore, the present invention relates to the RNA, compositions or kits as disclosed herein for use as a medicament. The present invention also provides the use of the RNA, compositions or kits as disclosed herein for increasing the expression of said encoded protein, in particular in gene therapy.

Claims (26)

1. A method of treating or preventing propionic acidemia wherein, the method comprises administering to a subject in need thereof an effective amount of

a purified RNA comprising at least one coding sequence encoding a PCCA protein that is at least 95% identical to the amino acid sequence of SEQ ID NO: 8175, wherein the coding sequence comprises the nucleic acid sequence of any one of SEQ ID NOs: 34289, 47346, 60403, 21232 and 73460 or a sequence at least 80% identical to the nucleic acid sequence of any one of SEQ ID NOs: 34289, 47346, 60403, 21232 and 73460.

2. The method of claim 1 , wherein the purified RNA comprises a poly(A) sequence of 10 to 200 adenosine nucleotides.

3. The method of claim 1 , wherein the RNA is an mRNA, a viral RNA or a replicon RNA.

4. The method of claim 3 , wherein the RNA is an mRNA.

5. The method of claim 1 , wherein the RNA is a modified RNA.

6. The method of claim 5 , wherein the modified RNA comprises a chemically modified nucleotide.

7. The method of claim 1 , wherein the RNA comprises a 5′-CAP structure, a 5′-untranslated region (5′-UTR), and/or at least one 3′-untranslated region element (3′-UTR).

8. The method of claim 7 , wherein the RNA comprises at least one histone stem-loop.

9. The method of claim 1 , wherein the RNA comprises, in 5′ to 3′ direction, the following elements:

a) a 5′-CAP structure,

b) the at least one coding sequence, and

c) a poly(A) tail.

10. The method of claim 9 , wherein the RNA comprises a 5′-UTR and a 3′-UTR.

11. The method of claim 1 , wherein the at least one coding sequence encodes the amino acid sequence of SEQ ID NO: 8175.

12. The method of claim 1 , wherein the at least one coding sequence comprises a sequence at least 90% identical to the nucleic acid sequence of any one of SEQ ID NOs: 34289, 47346, 60403, 21232 and 73460.

13. The method of claim 9 , further comprising administering an effective amount of a purified RNA comprising at least one coding sequence encoding a PCCB protein that is at least 95% identical to the amino acid sequence of SEQ ID NO: 8176.

14. The method of claim 13 , wherein the at least one coding sequence encodes the amino acid sequence of SEQ ID NO: 8176.

15. The method of claim 13 , wherein the at least one coding sequence comprises a sequence at least 90% identical to the nucleic acid sequence of any one of SEQ ID NOs: 34290, 47347, 60404, 21233 and 73461.

16. The method of claim 9 , further comprising administering an effective amount of

a purified RNA comprising at least one coding sequence encoding a PCCB protein that is at least 95% identical to the amino acid sequence of SEQ ID NO: 8176, wherein the coding sequence comprises the nucleic acid sequence of any one of SEQ ID NOs: 34290, 47347, 60404, 21233 and 73461 or a sequence at least 80% identical to the nucleic acid sequence of any one of SEQ ID NOs: 34290, 47347, 60404, 21233 and 73461.

17. The method of claim 1 , wherein the purified RNA comprises at least one 3′-untranslated region element (3′-UTR), wherein the 3′-UTR element comprises a nucleic acid sequence derived from a 3′-UTR of a gene selected from the group consisting of an albumin gene, an α-globin gene, a β-globin gene, a tyrosine hydroxylase gene, a lipoxygenase gene, and a collagen alpha gene.

18. The method of claim 17 , wherein the 3′-UTR element comprises a nucleic acid sequence derived from a 3′-UTR of an α-globin gene.

19. The method of claim 1 , wherein the purified RNA is formulated in a composition comprising lipid nanoparticles (LNPs).

20. The method of claim 19 , wherein the purified RNA is formulated in a composition comprising LNPs, said LNPs comprising a cationic lipid.

21. The method of claim 19 , wherein the composition is administered by injection.

Assignments (1)
CHANGE OF NAME Recorded Feb 8, 2023
From: CUREVAC AG
To: CUREVAC SE
Reel/Frame 062683/0254 →
Priority Claims (1)
WO PCT/EP2016/060111 · May 4, 2016 · international
Continuity (2)
Division 16098844
Related Publication 20220025369A1 · Jan 27, 2022
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