Salts and processes of preparing a PI3K inhibitor
The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.
1. A compound selected from the group consisting of:
a compound of Formula XIV:
or a pharmaceutically acceptable salt thereof;
a compound of Formula XV:
or a pharmaceutically acceptable salt thereof;
a compound of Formula XVI:
or a pharmaceutically acceptable salt thereof;
a compound of Formula XX:
or a pharmaceutically acceptable salt thereof; and
a compound of Formula XXI:
or a pharmaceutically acceptable salt thereof.
2. A process of preparing a crystalline hydrochloric acid salt of Formula I, comprising reacting a compound of Formula I:
with hydrochloric acid to form said salt, wherein the process comprises:
adding hydrochloric acid to the compound of Formula I at room temperature to form a slurry;
heating said slurry to a temperature of from about 45° C. to about 55° C. to form a solution; and
cooling the solution to a temperature of from about 0° C. to about 5° C. to crystallize said salt.
3. A process, comprising reacting a compound of Formula XVI:
with formamidine acetate to form a compound of Formula I:
4. The process of claim 3 , wherein said reacting of the compound of Formula XVI with formamidine acetate is conducted in a solvent component comprising 1,2-ethanediol.
5. The process of claim 3 , wherein said reacting of the compound of Formula XVI with formamidine acetate is performed at a temperature of from about 100° C. to about 105° C.
6. The process of claim 3 , wherein about 8 to about 10 equivalents of formamidine acetate is used based on 1 equivalent of the compound of Formula XVI.
7. The process of claim 3 , further comprising preparing the compound of Formula XVI by a process comprising reacting a compound of Formula XV:
with (1-ethoxyethylidene)malononitrile in the presence of a tertiary amine.
8. The process of claim 7 , wherein said tertiary amine is N-methylpyrrolidinone.
9. The process of claim 7 , wherein said reacting of the compound of Formula XV with with (1-ethoxyethylidene)malononitrile is performed at about room temperature.
10. The process of claim 7 , further comprising preparing the compound of Formula XV by a process comprising reacting a compound of Formula XIV-a:
with hydrazine in the presence of a tertiary amine, wherein P 1 is C 1-6 alkylsulfonyl.
11. The process of claim 10 , wherein said tertiary amine is N-methylpyrrolidinone.
12. The process of claim 10 , wherein said reacting of the compound of Formula XIV-a with hydrazine is performed at a temperature of from about 35° C. to about 60° C.
13. The process of claim 10 , wherein said reacting of the compound of Formula XIV-a with hydrazine is conducted in a solvent component comprising dichloromethane.
14. The process of claim 10 , wherein P 1 is methanesulfonyl group.
15. The process of claim 10 , further comprising preparing the compound of Formula XIV-a by a process comprising reacting a compound of Formula XIII:
with C 1-6 alkylsulfonylhalide in the presence of a tertiary amine.
16. The process of claim 15 , wherein said C 1-6 alkylsulfonylhalide is methanesulfonyl chloride.
17. The process of claim 15 , wherein said tertiary amine is N,N-diisopropylethylamine.
18. The process of claim 15 , wherein about 1.1 to about 1.5 equivalents of alkylsulfonylhalide is used based on 1 equivalent of the compound of Formula XIII.
19. The process of claim 15 , wherein said reacting of said compound of Formula XIII with C 1-6 alkylsulfonylhalide is performed at a temperature of from about −10° C. to about 5° C.
20. The process of claim 15 , wherein said reacting of said compound of Formula XIII with C 1-6 alkylsulfonylhalide is performed in a solvent component comprising dichloromethane.
21. The process of claim 15 , wherein the steps of: (i) reacting of said compound of Formula XIII with C 1-6 alkylsulfonylhalide; (ii) reacting said compound of Formula XIV-a with hydrazine in the presence of a tertiary amine to form a compound of Formula XV; and (iii) reacting said compound of Formula XV with formamidine acetate to form a compound of Formula XVI are conducted in the same pot without isolation of the compound of Formula XIV-a or the compound of Formula XV.
22. The process of claim 3 , further comprising preparing the compound of Formula XVI by a process comprising reacting a salt of Formula XV-a:
with (1-ethoxyethylidene)malononitrile in the presence of a tertiary amine, wherein TsOH is p-toluenesulfonic acid.
23. The process of claim 22 , wherein said tertiary amine is N,N-diisopropylethylamine.
24. The process of claim 22 , wherein said reacting a salt of Formula XV-a with with (1-ethoxyethylidene)malononitrile is performed at about room temperature.
25. The process of claim 22 , wherein about 1.3 to about 1.6 equivalents of (1-ethoxyethylidene)malononitrile is used based on 1 equivalent of the salt of Formula XV-a.
26. The process of claim 22 , wherein said reacting of the salt of Formula XV-a with with (1-ethoxyethylidene)malononitrile is conducted in a solvent component comprising ethanol.
27. The process of claim 22 , further comprising preparing the salt of Formula XV-a by a process comprising reacting a compound of Formula XXI:
with p-toluenesulfonic acid, wherein Boc is tert-butoxycarbonyl.
28. The process of claim 27 , wherein said p-toluenesulfonic acid is p-toluenesulfonic acid monohydrate.
29. The process of claim 27 , wherein about 1.3 to about 1.6 equivalents of p-toluenesulfonic acid is used based on 1 equivalent of the compound of Formula XXI.
30. The process of claim 27 , wherein said reacting of said compound of Formula XXI with p-toluenesulfonic acid is performed at a temperature of from about 45° C. to about 65° C.
31. The process of claim 27 , wherein reacting of said compound of Formula XXI with p-toluenesulfonic acid is conducted in a solvent component comprising ethanol.
32. The process of claim 27 , wherein the steps of: (i) reacting said compound of Formula XXI with p-toluenesulfonic acid to form a salt of Formula XV-a; and (ii) reacting said salt of Formula XV-a with (1-ethoxyethylidene)malononitrile are conducted in the same pot without isolation of the salt of Formula XV-a.
33. The process of claim 27 , further comprising preparing the compound of Formula XXI by a process comprising reacting a compound of Formula XX:
with hydrogen gas in the presence of one or more independently selected hydrogenation catalysts, wherein Boc is t-butoxycarbonyl.
34. The process of claim 33 , wherein said reacting of the compound of Formula XX with hydrogen gas is performed in the presence of two independently selected hydrogenation catalysts.
35. The process of claim 34 , wherein one hydrogenation catalyst is bis(1,5-cyclooctadiene)rhodium(I)tetrafluoroborate and the other is (R)-(−)-1-{(S)-2-[bis(4-trifluoromethylphenyl)phosphine]ferrocenyl}ethyl-di-t-butylphosphine.
36. The process of claim 35 , wherein about 13.5 to about 14.5 equivalents of the compound of Formula XX is used based on 1 equivalent of bis(1,5-cyclooctadiene)rhodium(I)tetrafluoroborate.
37. The process of claim 35 , wherein about 12 to about 13 equivalents of the compound of Formula XX is used based on 1 equivalent of (R)-(−)-1-{(8)-2-[bis(4-trifluoromethylphenyl)phosphine]ferrocenyl}ethyl-di-t-butylphosphine.
38. The process of claim 33 , wherein said reacting of the compound of Formula XX with hydrogen gas is performed at about room temperature.
39. The process of claim 33 , wherein said reacting of the compound of Formula XX with hydrogen gas is conducted in a solvent component comprising methanol.
40. The process of claim 33 , further comprising preparing the compound of Formula XX by a process comprising reacting a compound of Formula XIX:
with t-butyl carbazate.
41. The process of claim 40 , wherein said reacting of the compound of Formula XIX with t-butyl carbazate is performed at a temperature of from about 60° C. to about 70° C.
42. The process of claim 40 , wherein said reacting of the compound of Formula XIX with t-butyl carbazate is conducted in a solvent component comprising methanol.
43. The process of claim 40 , further comprising preparing the compound of Formula XIX by a process comprising oxidizing a compound of Formula XIII-a:
in the presence of an oxidizing agent.
44. The process of claim 43 , wherein said oxidizing agent is Dess-Martin periodinane.
45. The process of claim 43 , wherein about 1.2 to about 1.7 equivalents of said oxidizing agent is used based on 1 equivalent of the compound of Formula XIII-a.
46. The process of claim 43 , wherein said oxidizing of the compound of Formula XIII-a is performed at about room temperature.
47. The process of claim 43 , wherein said oxidizing of the compound of Formula XIII-a is conducted in a solvent component comprising dichloromethane.
48. The process of claim 3 , further comprising reacting the compound of Formula I:
with hydrochloric acid to form a crystalline hydrochloric acid salt of the compound of Formula I, wherein the reacting comprises:
adding hydrochloric acid to the compound of Formula I at room temperature to form a slurry;
heating said slurry to a temperature of from about 45° C. to about 55° C. to form a solution; and
cooling the solution to a temperature of from about 0° C. to about 5° C. to crystallize said salt.