Pill with needle delivery system having outwardly expanding mechanical actuation
A device can include a capsule containing an array of microneedles and a mechanical actuator. The device can be in an ingestible form for delivery to a duodenum or other target location within a subject and can release the mechanical actuator from constraint by the capsule in response to stimuli or conditions in or en route to the duodenum or other target location. The mechanical actuator upon release from constraint by the capsule can expand outwardly (e.g., responsive to a bias provided by a flexibly resilient material of the mechanical actuator) in a direction away from a central longitudinal axis of the mechanical actuator and drive the array of microneedles into penetrating engagement with a lining of the duodenum or other target location. The penetrating engagement can facilitate delivery of a biotherapeutic agent or other payload via the microneedles.
1 . A system comprising:
a capsule comprising a shell having:
an inner surface defining an interior volume of the capsule; and
an outer surface;
a carrier sized to fit within the interior volume of the capsule and bearing an array of microneedles; and
a mechanical actuator operable for moving the carrier outwardly to cause the microneedles to engage tissue, the mechanical actuator comprising:
a foldable biasing member comprising a first end and a second end, the foldable biasing member including a foldable portion comprising a flexibly resilient material having a flexibility permitting the first end and the second end to be foldable toward one another for movement from an expanded state toward a collapsed state in which the mechanical actuator fits within the interior volume of the capsule, the flexibly resilient material further having a resiliency that biases the first end and the second end apart from one another for movement from the collapsed state toward the expanded state to move the carrier outwardly upon the mechanical actuator overcoming or escaping from constraint provided by the capsule; and
a holder hingedly attached with the first end of the biasing member by a hinge distinct from the foldable portion of the biasing member such that the holder is pivotable about the hinge relative to the first end of the biasing member, the holder comprising a support surface for supporting the carrier bearing the array of microneedles.
2 . The system of claim 1 , further comprising a linkage coupled with the first end of the foldable biasing member.
3 . The system of claim 2 , wherein the linkage comprises a channel in which the holder is received in the collapsed state to space apart tips of the array of microneedles from the inner surface of the capsule.
4 . The system of claim 2 , wherein the holder is hingedly attached with the first end of the biasing member via the hinge, and wherein the hinge is included at least in part on the linkage.
5 . The system of claim 4 , further comprising a hinge stopping surface included on the holder or the linkage and arranged to prevent rotation of the hinge past a predetermined limit.
6 . The system of claim 1 , wherein the foldable biasing member comprises a nitinol wire.
7 . The system of claim 1 , wherein the foldable biasing member is a first foldable biasing member, and wherein the holder is hingedly attached at opposite sides to the first foldable biasing member and a second foldable biasing member.
8 . The system of claim 1 , wherein the foldable biasing member and the holder are included in an assembly comprising:
a first holder and a second holder;
a first linkage, a second linkage, a third linkage, and a fourth linkage; and
a first foldable biasing member and a second foldable biasing member arranged such that:
the first foldable biasing member has opposite ends received respectively in the first linkage and the second linkage;
the second foldable biasing member has opposite ends received respectively in the third and fourth linkages;
the first holder is hingedly coupled at opposite sides to the first linkage and the third linkage; and
the second holder is hingedly coupled at opposite sides to the second linkage and the fourth linkage.
9 . The system of claim 1 , wherein the holder is a first holder that comprises a releasable attachments surface arranged to attach to a second holder in the collapsed state and configured to release to permit symmetric deployment of the first holder and the second holder relative to one another.
10 . The system of claim 1 , comprising at least three holders interconnected by at least three foldable biasing members arranged to respectively extend between laterally adjacent holders.
11 . The system of claim 1 , wherein the outer surface of the capsule is sized to a target location within a subject.
12 . The system of claim 1 , wherein the outer surface of the capsule is sized to pass through a body lumen.
13 . The system of claim 12 , wherein the body lumen through which the outer surface is sized to pass is a gastrointestinal tract.
14 . A system comprising a mechanical actuator configured for microneedle delivery, the mechanical actuator comprising:
a foldable biasing member comprising a first end and a second end, the foldable biasing member including a foldable portion comprising a flexibly resilient material having a flexibility permitting the first end and the second end to be foldable toward one another for movement from an expanded state toward a collapsed state in which the mechanical actuator fits within a volume sized to fit within a capsule, the flexibly resilient material further having a resiliency that biases the first end and the second end apart from one another for movement from the collapsed state toward the expanded state; and
a holder hingedly attached with the first end of the biasing member by a hinge distinct from the foldable portion of the biasing member such that the holder is pivotable about the hinge relative to the first end of the biasing member, the holder comprising a support surface configured for supporting a carrier bearing an array of microneedles, the support surface configured for supporting the carrier for outward movement for deployment of the microneedles in response to movement from the collapsed state toward the expanded state.
15 . The system of claim 14 , further comprising the carrier bearing the array of microneedles.
16 . The system of claim 14 , further comprising the capsule.
17 . The system of claim 14 , wherein the foldable biasing member and the holder are included in an assembly comprising:
a first holder and a second holder;
a first linkage, a second linkage, a third linkage, and a fourth linkage; and
a first foldable biasing member and a second foldable biasing member arranged such that:
the first foldable biasing member has opposite ends received respectively in the first linkage and the second linkage;
the second foldable biasing member has opposite ends received respectively in the third and fourth linkages;
the first holder is hingedly coupled at opposite sides to the first linkage and the third linkage; and
the second holder is hingedly coupled at opposite sides to the second linkage and the fourth linkage.
18 . The system of claim 14 , wherein the capsule is an ingestible capsule.