METHODS OF USING OBETICHOLIC ACID
The disclosure relates to methods of using obeticholic acid or pharmaceutically acceptable salt or amino acid conjugate thereof for slowing down or reversing the progression of compensated cirrhosis.
1 . A method of treating compensated cirrhosis in a subject in need thereof comprising administering to the subject obeticholic acid or a pharmaceutically acceptable salt or amino acid conjugate thereof in an amount of 1-25 mg.
2 . The method of claim 1 , wherein the compensated cirrhosis is associated with NASH.
3 . The method of claim 1 , wherein the obeticholic acid is administered in the amount of 10 mg.
4 . The method of claim 1 , wherein the obeticholic acid is administered in the amount of 25 mg.
5 . A method of treating NASH in a subject with compensated cirrhosis due to NASH comprising administering to the subject obeticholic acid or a pharmaceutically acceptable salt or amino acid conjugate thereof in an amount of 1-25 mg.
6 . The method of claim 5 , wherein the obeticholic acid is administered in the amount of 10 mg.
7 . The method of claim 5 , wherein the obeticholic acid is administered in the amount of 25 mg.
8 . A method of treating liver fibrosis in a subject with compensated cirrhosis due to NASH comprising administering to the subject obeticholic acid or a pharmaceutically acceptable salt or amino acid conjugate thereof in an amount of 1-25 mg.
9 . The method of claim 8 , wherein the obeticholic acid is administered in the amount of 10 mg.
10 . The method of claim 8 , wherein the obeticholic acid is administered in the amount of 25 mg.
11 . The method of claim 1 , wherein the subject is not suffering from a cholestatic condition.
12 . The method of claim 5 , wherein the subject is not suffering from a cholestatic condition.
13 . The method of claim 8 , wherein the subject is not suffering from a cholestatic condition.