IP Library › Granted Patent US 12,233,239
Granted Patent B2
US 12,233,239 · App. 17/386,108 · Granted Feb 25, 2025

Advanced step therapy delivery for an ambulatory infusion pump and system

Inventors: David DeBelser (Plymouth, MN); Clinton Robert Hetchler (Minnetonka, MN); David Pardee Sours (North Saint Paul, MN); Michael Wade Kersch (Saint Michael, MN)
Assignee: ICU Medical, Inc.
A61M5/172A61M5/14244A61M5/168G16H20/17G16H40/63A61M2005/14208A61M2205/3334A61M2205/502
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Quick Facts
Patent No.
US 12,233,239
App. No.
17/386,108
Granted
Feb 25, 2025
Kind
B2
Abstract

Embodiments relate to systems, methods and devices for delivering a drug or other therapy to a patient with an ambulatory infusion pump configured to provide a series of tolerance-building steps leading up to a plateau delivery rate. The plateau delivery rate is maintained until the prescribed amount of drug or therapy fluid is delivered to the patient. Embodiments of the invention include providing the patient or other user with a mechanism to decrease, or step down, the therapy delivery rate if a tolerance was not achieved at a lower rate, and providing notifications prior to a step up in a dosage delivery rate.

Claims (28)

1. An ambulatory infusion pump for providing step delivery therapy to a patient comprising:

a pump control system configured to control operation of a pumping mechanism; and

a control module configured to relay commands to the pump control system,

wherein the control module is configured to receive a passcode and a plurality of predefined parameters defining a step delivery therapy profile having a first medicament delivery rate, a current step duration, and a new step duration, the control module further configured to, upon entry of the passcode, step up the medicament delivery rate to a second medicament delivery rate for the new step duration independent of progress on the current step duration when the step up command was entered.

2. The ambulatory infusion pump of claim 1 , wherein the control module is further configured to, without entry of the passcode, maintain the first medicament delivery rate for the new step duration.

3. The ambulatory infusion pump of claim 1 , wherein the control module is further configured to, upon entry of the passcode, permit control over medicament delivery rates by entering multiple step up commands to a plateau rate.

4. The ambulatory infusion pump of claim 3 , wherein the control module is further configured such that the passcode does not need to be reentered for each step up command.

5. The ambulatory infusion pump of claim 1 , wherein the medicament is for a treatment of at least one of an immune deficiency, inflammation disorder, autoimmune disorder, and/or acute infection.

6. The ambulatory infusion pump of claim 1 , wherein the medicament is an intravenous immunoglobulin (IVIG).

7. The ambulatory infusion pump of claim 1 , wherein the control module enables adjustment of the step delivery profile during the therapy session in response to a failure to achieve a desired tolerance at any given tolerance-building delivery rate.

8. The ambulatory infusion pump of claim 7 , wherein in response to the failure to achieve a desired tolerance during the therapy session, a duration of implementing the step delivery profile is automatically lengthened.

9. The ambulatory infusion pump of claim 8 , wherein in response to the failure to achieve a desired tolerance during the therapy session, infusion of medicament is reduced to a minimum keep vein open (KVO) rate.

10. The ambulatory infusion pump of claim 1 , wherein the control module is configured to provide a notification to prompt the monitoring of a vital sign and/or condition of the patient prior to stepping up the medicament delivery rate.

11. The ambulatory infusion pump of claim 10 , wherein a status of the monitored vital sign and/or condition of the patient prompts the control module to issue a hold dosage flag.

12. The ambulatory infusion pump of claim 11 , wherein the hold dosage flag is cleared upon entry of the passcode and a step up command.

13. An ambulatory infusion pump configured to graphically illustrate progress along a programmed step delivery profile during a therapy session, the ambulatory infusion pump comprising:

a pump control system configured to control operation of a pumping mechanism according to one or more delivery rates defined by the programmed step delivery profile; and

a control module in communication with the pump control system, the control module including a user interface presenting an indicator graphic along with a step delivery profile graphic configured to illustrate progress along the step delivery profile during the therapy session,

wherein the user interface is further configured to receive a passcode to permit stepping up the one or more delivery rates for a predefined new step duration independent of progress along the step delivery profile and to change the presentation of the step delivery profile graphic to reflect the step up.

14. The ambulatory infusion pump of claim 13 , wherein the pumping mechanism is configured to dispense medicament for a treatment of at least one of an immune deficiency, inflammation disorder, autoimmune disorder, and/or acute infection.

15. The ambulatory infusion pump of claim 13 , wherein the medicament is an intravenous immunoglobulin (IVIG).

16. The ambulatory infusion pump of claim 13 , wherein the control module enables adjustment of the step delivery profile during the therapy session in response to a failure of a patient to achieve a desired tolerance at any given delivery rate.

17. An ambulatory infusion pump configured to deliver medicament according to a customized delivery profile that enables a patient to gradually build up a tolerance to the medicament during a therapy session, the ambulatory infusion pump comprising:

a pump control system configured to control operation of a pumping mechanism according to one or more tolerance-building delivery rates defined by a step delivery profile; and

a control module in communication with the pump control system, the control module including a user interface presenting an indicator graphic along with a step delivery profile graphic configured to illustrate progress along the step delivery profile during the therapy session,

wherein the user interface is further configured to receive a passcode to permit stepping up one of the one or more tolerance-building delivery rates for a predefined new step duration independent of progress along the step delivery profile and to change the presentation of the step delivery profile graphic to reflect the step up.

18. The ambulatory infusion pump of claim 17 , wherein the control module is further configured to, without entry of the passcode, step down one of the one or more tolerance-building delivery rates for the predefined new step duration.

19. The ambulatory infusion pump of claim 18 , wherein the control module is further configured to, without entry of the passcode, step up one of the one or more tolerance-building delivery rates to a tolerance-building delivery rate previously delivered for the step delivery therapy profile.

Assignments (4)
MERGER Recorded Oct 2, 2024
From: SMITHS MEDICAL ASD, INC.
To: ICU MEDICAL, INC.
Reel/Frame 069101/0767 →
SECURITY AGREEMENT Recorded Aug 16, 2022
From: SMITHS MEDICAL ASD, INC.
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 061179/0320 →
CORRECTIVE ASSIGNMENT TO CORRECT THE CONVEYING PARTY DATE PREVIOUSLY RECORDED AT REEL: 059426 FRAME: 0733. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT . Recorded Mar 29, 2022
From: DEBELSER, DAVID; HETCHLER, CLINTON ROBERT; SOURS, DAVID PARDEE; KERSCH, MICHAEL WADE
To: SMITHS MEDICAL ASD, INC.
Reel/Frame 061086/0808 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 9, 2021
From: DEBELSER, DAVID; HETCHLER, CLINTON ROBERT
To: SMITHS MEDICAL ASD, INC.
Reel/Frame 058058/0733 →
Continuity (4)
Continuation 16023505 · Jun 29, 2018
Continuation 14525579 · Oct 28, 2014
Continuation 12631076 · Dec 4, 2009
Related Publication 20220016342A1 · Jan 20, 2022
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