Fundus imaging for microvascular assessment
An example system for microvascular assessment of a patient can include: a fundus imaging device including: a camera configured to capture one or more images of an eye of the patient; and at least one light source; and a microvascular assessment computing device including: a processor; and memory encoding instructions which, when executed by the processor, cause the system to: activate the light source to direct light at a fundus of the eye of the patient; capture, with the camera, one or more images of the fundus of the patient, the fundus comprising a plurality of blood vessels; and analyze with the microvascular assessment computing device, the one or more images to determine a microvasculature health index for the patient.
1. A system for microvascular assessment of a patient, the system comprising:
a fundus imaging device comprising:
a camera configured to capture one or more images of an eye of the patient; and
at least one light source; and
a microvascular assessment computing device comprising:
a processor; and
memory encoding instructions which, when executed by the processor, cause the system to:
activate the light source to direct light at a fundus of the eye of the patient;
capture, with the camera, one or more images of the fundus of the patient, the fundus comprising a plurality of blood vessels;
analyze, with the microvascular assessment computing device, the one or more images to determine a penetration rate and a dispersion rate of a fluorescent dye in the blood vessels in the fundus; and
determine, based on the penetration rate and the dispersion rate, a microvasculature health index for the patient.
2. The system of claim 1 , wherein the at least one light source is an infrared light emitting diode.
3. The system of claim 1 , wherein the memory further encodes instructions, which, when executed by the processor, cause the system to measure a diameter of a pupil of the patient.
4. The system of claim 1 , wherein the memory further encodes instructions, which, when executed by the processor, cause the system to:
manipulate the one or more images of the fundus to localize edges of blood vessels in the fundus;
trace the blood vessels from a primary artery to determine branching point locations of the blood vessels;
calculate diameters of the blood vessels before and after each branching point location;
determine distances between each branching point location; and
compute ratios of the diameters of the branching point locations and the distances between the branching point locations.
5. The system of claim 1 , further comprising a color bandpass filter.
6. The system of claim 1 , further comprising a polarization filter.