IP Library › Granted Patent US 11,913,013
Granted Patent B2
US 11,913,013 · App. 17/389,421 · Granted Feb 27, 2024

Chimpanzee adenoviral vector-based filovirus vaccines

Inventors: Nancy J. Sullivan (Kensington, MD); Gary J. Nabel (Washington, DC); Clement Asiedu (Olney, MD); Cheng Cheng (Rockville, MD); Alfredo Nicosia (Rome, IT); Riccardo Cortese (Rome, IT); Virginia Ammendola (Naples, IT); Stefano Colloca (Rome, IT)
Assignee: SABIN VACCINE INSTITUTE
C12N15/86A61K39/12C07K14/005C07K14/08C12N15/861A61K2039/5254A61K2039/5256A61K2039/545C12N7/00C12N15/8636C12N2710/10341C12N2710/10343C12N2710/24111C12N2710/24141C12N2760/14111C12N2760/14134
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Quick Facts
Patent No.
US 11,913,013
App. No.
17/389,421
Granted
Feb 27, 2024
Kind
B2
Abstract

This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebolavirus (EBOV) or Marburg virus (MARV).

Claims (5)

1. An isolated nucleic acid molecule, wherein the isolated nucleic acid molecule comprises a sequence selected from the group consisting of SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, and SEQ ID NO:9.

2. The isolated nucleic acid molecule of claim 1 , further comprising a promoter operably linked to said nucleic acid molecule.

3. The isolated nucleic acid molecule of claim 2 , wherein the promoter is a CMV promoter.

4. A composition, comprising the isolated nucleic acid molecule of claim 1 and a pharmaceutically acceptable carrier.

5. The composition of claim 4 , wherein the isolated nucleic acid molecule is contained in a viral particle.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 4, 2021
From: GLAXOSMITHKLINE BIOLOGICALS SA
To: SABIN VACCINE INSTITUTE
Reel/Frame 057073/0361 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 2, 2021
From: OKAIROS AG
To: GLAXOSMITHKLINE BIOLOGICALS SA
Reel/Frame 057054/0886 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 30, 2021
From: SULLIVAN, NANCY J.; NABEL, GARY J.; ASIEDU, CLEMENT; CHENG, CHENG
To: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
Reel/Frame 057029/0327 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 30, 2021
From: NICOSIA, ALFREDO; CORTESE, RICCARDO; COLLOCA, STEFANO; AMMENDOLA, VIRGINIA
To: OKAIROS AG
Reel/Frame 057043/0406 →