Isoxazoline compositions and use thereof in the prevention or treatment of parasite infestations in animals
This invention is directed to a pharmaceutical composition for drinking water administration comprising isoxazoline compounds of formula (I) and a polysorbate surfactant and diethylene glycol monoethyl ether (transcutol); and the use of the composition to treat or prevent parasite infestations of animals.
1. A method of preventing or treating parasite infestations in animals by administering to such animal in its drinking water a pharmaceutical composition comprising fluralaner or a salt or solvate thereof, and a pharmaceutically acceptable carrier comprising diethylene glycol monoethyl ether and a polysorbate surfactant, wherein the polysorbate is 30 to 80% by weight of the pharmaceutical composition.
2. The method according to claim 1 comprising between 1.5 mg/ml and 100 mg/ml of fluralaner.
3. The method according to claim 1 wherein the ratio of diethylene glycol monoethyl ether to polysorbate surfactant is <about 25/75 w/w.
4. The method according to claim 1 wherein the animals are selected from pigs and poultry.
5. The method according to claim 4 wherein the animals are laying hens.
6. The method according to claim 1 wherein the parasite infestation is a mite infestation.
7. The method according to claim 6 wherein the mite infestation is an infestation with Dermanyssus sp. or Ornithonyssus sp.
8. A Medicated drinking water comprising a mixture of a pharmaceutical composition comprising fluralaner or a salt or solvate thereof, and a pharmaceutically acceptable carrier comprising diethylene glycol monoethyl ether and a polysorbate surfactant and water, wherein the polysorbate is 30 to 80% by weight of the pharmaceutical composition.
9. The Medicated drinking water according to claim 8 comprising between 0.001 and 1 mg/ml of the fluralaner compound.
10. A Method for preparing medicated drinking water according to claim 8 wherein the pharmaceutical composition is diluted by injecting through a dosing pump system in a water system or by mixing with water in a medication tank.
11. The method of claim 1 , wherein the polysorbate surfactant is polysorbate 80.
12. The medicated drinking water of claim 8 , wherein the polysorbate surfactant is polysorbate 80.