Methods of production of arginine-silicate complexes

1. A method of manufacturing an inositol-stabilized arginine-silicate (“ASP”) complex comprising:

combining arginine with a silicate salt and inositol to form a solution comprising the arginine, the silicate salt, and the inositol; and

spray drying the solution using varied conical diameters to obtain a particle size distribution of the ASI complex;

wherein about 100% of the particles are of a size less than 250 μm, and less than 100% of the particles are of a size less than 74 μm.

2. The method of claim 1 , further comprising adjusting a synthesis temperature or temperatures, and making adjustments to a rotary or nozzle atomizer.

3. The method of claim 1 , further comprising one or more micronization steps.

4. The method of claim 3 , wherein the micronization is achieved by spray drying.

5. An inositol-stabilized arginine-silicate (“ASP”) complex comprising a particle size distribution wherein 98% of the particles are of a size and shape to pass through a 125 micron mesh size.

6. The ASI complex of claim 5 comprising a mixture of particles wherein approximately 67% of particles are of sizes between about 0.1 μm and about 75 μm, and approximately 33% of particles are of sizes between about 76 μm and about 200 μm.

7. The ASI complex of claim 5 comprising approximately 50% of particles with sizes between about 0.1 μm and about 75 μm, and approximately 50% between about 76 μm and about 200 μm.

8. The method of claim 1 , wherein the silicate salt is potassium silicate.

9. The method of claim 1 , further comprising heating the solution.

10. An inositol-stabilized arginine-silicate (“ASI”) complex having a particle size distribution wherein about 100% of the particles are of a size less than 250 μm, and less than 100% of the particles are of a size less than 74 μm.

11. The ASI complex of claim 10 , wherein at least 50% of the particles are of sizes between about 0.1 μm and about 75 μm.

12. The ASI complex of claim 10 , wherein at least 67% of the particles are of sizes between about 0.1 μm and about 75 μm.

13. The ASI complex of claim 10 , wherein at least 98% of the particles are of a size less than 125 μm, at least 88% of the particles are of a size less than 106 μm, at least 81% of the particles are of a size less than 90 μm, at least 67% of the particles are of a size less than 75 μm, or at least 44% of the particles are of a size less than 63 μm.

14. The ASI complex of claim 10 , wherein between 50-67% of particles are of sizes between about 0.1 μm and about 75 μm, and between 33-50% of particles are of sizes between about 76 μm and about 200 μm.

15. The ASI complex of claim 10 , wherein about 88% of the particles are of a size less than about 100 μm.

16. The ASI complex of claim 10 , wherein at least 98% of the particles are of a size and shape to pass through a 125 micron mesh size.

17. The ASI complex of claim 10 , wherein approximately 67% of particles are of sizes between about 0.1 μm and about 75 μm, and approximately 33% of particles are of sizes between about 76 μm and about 200 μm.

18. The ASI complex of claim 10 , wherein approximately 50% of particles are of sizes between about 0.1 μm and about 75 μm, and approximately 50% of particles are of sizes between about 76 μm and about 200 μm.

19. The ASI complex of claim 10 , wherein about 98% of the particles are of a size less than 125 μm, about 88% of the particles are of a size less than 106 μm, about 81% of the particles are of a size less than 90 μm, about 67% of the particles are of a size less than 75 μm, or about 44% of the particles are of a size less than 63 μm.

20. The ASI complex of claim 10 , wherein about 100% of the particles are of a size less than 180 μm.

21. A method of making a beverage comprising combining a liquid with an inositol-stabilized arginine-silicate (“ASP”) complex, wherein the ASI complex has a particle size distribution wherein about 100% of the particles are of a size less than 250 μm, and less than 100% of the particles are of a size less than 74 μm.

22. The method of claim 14 , wherein at least 50% of the particles are of sizes between about 0.1 μm and about 75 μm.

23. The method of claim 14 , wherein at least 67% of the particles are of sizes between about 0.1 μm and about 75 μm.

24. The method of claim 14 , wherein at least 98% of the particles are of a size less than 125 μm, at least 88% of the particles are of a size less than 106 μm, at least 81% of the particles are of a size less than 90 μm, at least 67% of the particles are of a size less than 75 μm, or at least 44% of the particles are of a size less than 63 μm.

25. The method of claim 21 , wherein between 50-67% of particles are of sizes between about 0.1 μm and about 75 μm, and between 33-50% of particles are of sizes between about 76 μm and about 200 μm.

26. The method of claim 14 , wherein about 88% of the particles are of a size less than about 100 μm.

27. The method of claim 14 , wherein at least 98% of the particles are of a size and shape to pass through a 125 micron mesh size.

28. The method of claim 14 , wherein approximately 67% of particles are of sizes between about 0.1 μm and about 75 μm, and approximately 33% of particles are of sizes between about 76 μm and about 200 μm.

29. The method of claim 14 , wherein approximately 50% of particles are of sizes between about 0.1 μm and about 75 μm, and approximately 50% of particles are of sizes between about 76 μm and about 200 μm.

30. The method of claim 14 , wherein about 98% of the particles are of a size less than 125 μm, about 88% of the particles are of a size less than 106 μm, about 81% of the particles are of a size less than 90 μm, about 67% of the particles are of a size less than 75 μm, or about 44% of the particles are of a size less than 63 μm.

31. The method of claim 14 , wherein about 100% of the particles are of a size less than 180 μm.