2-aminoquinazolinone derivative
The present invention provides a 2-aminoquinazolinone derivative. The present invention is a compound represented by formula (1) [wherein X 1 represents CR or N, X 2 represents CR 2 or N, X 3 represents CR 3 or N, Y represents an optionally substituted C 6-10 aryl or optionally substituted 6 to 10-membered heteroaryl, Z represents an optionally substituted C 6-10 aryl, R A represents a hydrogen atom, halogen, cyano, optionally substituted C 1-6 alkyl sulfonyl, optionally substituted C 1-6 alkyl, or optionally substituted C 1-6 alkoxy, and R 1 , R 2 , and R 3 independently represent a hydrogen atom, halogen, optionally substituted C 1-6 alkyl, or optionally substituted C 1-6 alkoxy] or a pharmaceutically acceptable salt thereof.
1. A compound selected from:
2-anilino-6-fluoro-3-phenylquinazolin-4(3H)-one,
2-{4-[(azetidin-1-yl)methyl]anilino}-6-chloro-3-phenylquinazolin-4(3H)-one and
6-chloro-2-{4-[(3,3-difluorazetidin-1-yl)methyl]anilino}-3-phenylquinazolin-4(3H)-one or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein the compound is 2-anilino-6-fluoro-3-phenylquinazolin-4(3H)-one, or pharmaceutically acceptable salt thereof.
3. The compound of claim 1 , wherein the compound is 2-{4-[(azetidin-1-yl)methyl]anilino}-6-chloro-3-phenylquinazolin-4(3H)-one, or pharmaceutically acceptable salt thereof.
4. The compound of claim 1 , wherein the compound is 6-chloro-2-{4-[(3,3 difluoroazetidin-1-yl)methyl]anilino}-3-phenylquinazolin-4(3H)-one, or pharmaceutically acceptable salt thereof.
5. A pharmaceutical composition comprising an effective amount of the compound or pharmaceutically acceptable salt thereof according to claim 1 .
6. A pharmaceutical composition comprising an effective amount of the compound or pharmaceutically acceptable salt thereof according to claim 1 , and one or more pharmaceutically acceptable excipient.
7. A pharmaceutical composition comprising an effective amount of the compound or pharmaceutically acceptable salt thereof according to claim 2 .
8. A pharmaceutical composition comprising an effective amount of the compound or pharmaceutically acceptable salt thereof according to claim 2 , and one or more pharmaceutically acceptable excipient.
9. A pharmaceutical composition comprising an effective amount of the compound or pharmaceutically acceptable salt thereof according to claim 3 .
10. A pharmaceutical composition comprising an effective amount of the compound or pharmaceutically acceptable salt thereof according to claim 3 , and one or more pharmaceutically acceptable excipient.
11. A pharmaceutical composition comprising an effective amount of the compound or pharmaceutically acceptable salt thereof according to claim 4 .
12. A pharmaceutical composition comprising an effective amount of the compound or pharmaceutically acceptable salt thereof according to claim 4 , and one or more pharmaceutically acceptable excipient.