IP Library › Granted Patent US 12,310,728
Granted Patent B2
US 12,310,728 · App. 17/396,549 · Granted May 27, 2025

Systems and interfaces for blood sampling

Inventor: David Brancazio (Cambridge, MA)
Assignee: YourBio Health, Inc.
A61B5/150099A61B5/1411A61B5/150022A61B5/150267A61B5/150343A61B5/150389A61B5/150412A61B5/150534A61B5/150732A61B5/150969A61B5/15105A61B5/15107A61B10/0051A61B10/0064A61B10/02A61B5/1438A61B5/150167A61B5/150175A61B5/150946A61B5/15115A61B5/15142A61B5/154
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Quick Facts
Patent No.
US 12,310,728
App. No.
17/396,549
Granted
May 27, 2025
Kind
B2
Abstract

The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood from subjects. In one aspect, the present invention is directed to devices and methods for receiving or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a substance transfer component (for example, one or more needles or microneedles) and a reduced pressure or vacuum chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some embodiments, the device may contain a “snap dome” or other deformable structure, which may be used, at least in part, to urge or move needles or other suitable substance transfer components into the skin of a subject. In some cases, for example, the device may contain a flexible concave member and a needle mechanically coupled to the flexible concave member such that the needle may be urged or moved into the skin using the flexible concave member. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

Claims (38)

1. A device for receiving fluid from a subject, the device comprising:

a device actuator;

a flexible concave member, wherein the flexible concave member is moveable from a first configuration to a second configuration in response to actuation of the device actuator;

a spring positioned such that actuation of the device actuator causes compression of the spring;

at least one cutter, wherein the at least one cutter is configured to move from a first position to a second position in response to actuation of the device actuator; and

a vacuum source, wherein vacuum from the vacuum source is mechanically created.

2. The device of claim 1 , wherein the at least one cutter comprises a needle.

3. The device of claim 1 , wherein the device is configured such that movement of the flexible concave member from the first configuration to the second configuration causes the at least one cutter to move from the first position to the second position.

4. The device of claim 1 , wherein the spring is configured to move the at least one cutter towards the first position after the at least one cutter reaches the second position.

5. The device of claim 1 , wherein the flexible concave member is configured to spontaneously return from the second configuration to the first configuration.

6. The device of claim 1 , wherein the at least one cutter comprises a microneedle.

7. The device of claim 1 , wherein the at least one cutter comprises a blade.

8. The device of claim 5 , wherein actuation of the device actuator comprises pushing the device actuator, and release of the device actuator permits the flexible concave member to spontaneously return from the second configuration to the first configuration.

9. The device of claim 1 , wherein actuation of the device actuator comprises pushing the device actuator, and release of the device actuator permits the spring to decompress.

10. The device of claim 9 , wherein decompression of the spring causes the flexible concave member to move from the second configuration back toward the first configuration.

11. The device of claim 1 , further comprising a collection chamber that is removably coupleable to the device.

12. The device of claim 11 , wherein the collection chamber is removably coupled to the device.

13. The device of claim 1 , wherein the flexible concave member includes a hole.

14. A method, comprising:

applying a device to a subject's skin, the device comprising a device actuator, at least one cutter, a flexible concave member, a spring, and a vacuum source; and

actuating the device actuator to cause:

the flexible concave member to move from a first configuration to a second configuration,

the at least one cutter to move and contact the subject's skin,

compression of the spring, and

actuation of the vacuum source to cause fluid from the subject to be drawn into the device, wherein vacuum from the vacuum source is mechanically created.

15. The method of claim 14 , wherein the at least one cutter is a needle.

16. The method of claim 14 , further comprising receiving the fluid into a collection chamber coupled to the device.

17. The method of claim 16 , further comprising removing the collection chamber from the device after receiving the fluid into the collection chamber.

18. The method of claim 16 , further comprising attaching the collection chamber to the device prior to actuating the device actuator.

19. The method of claim 14 , further comprising releasing the device actuator to allow the flexible concave member to move from the second configuration back toward the first configuration.

20. The method of claim 19 , wherein releasing the device actuator permits the compressed spring to decompress.

21. The method of claim 20 , wherein decompression of the spring causes the flexible concave member to move from the second configuration back toward the first configuration.

22. The method of claim 14 , wherein movement of the flexible concave member from the first configuration to the second configuration causes the at least one cutter to move.

23. The method of claim 14 , wherein actuating the device actuator comprises pushing the device actuator, causing the flexible concave member to be pressed down upon to move the flexible concave member from the first configuration to the second configuration.

24. The method of claim 14 , wherein releasing the device actuator permits the compressed spring to decompress.

25. The method of claim 14 , wherein the at least one cutter comprises a microneedle.

26. The method of claim 14 , wherein the at least one cutter comprises a blade.

27. The method of claim 14 , wherein the flexible concave member includes a hole.

Assignments (2)
CHANGE OF NAME Recorded Sep 17, 2021
From: SEVENTH SENSE BIOSYSTEMS, INC.
To: YOURBIO HEALTH, INC.
Reel/Frame 057538/0050 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 9, 2021
From: BRANCAZIO, DAVID
To: SEVENTH SENSE BIOSYSTEMS, INC.
Reel/Frame 057117/0443 →
Continuity (5)
Continuation 15297253 · Oct 19, 2016
Continuation 14327987 · Jul 10, 2014
Continuation 13292254 · Nov 9, 2011
Provisional Application 61411566 · Nov 9, 2010
Related Publication 20220133192A1 · May 5, 2022
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