REGENERATION OF DAMAGED TISSUE
A method of healing a wound including contacting a wound edge with a tropoelastin or elastin derived peptide in conditions for enabling a sustained contact of the tropoelastin with the wound edge for a time period for enabling re-epithelialization of the wound.
1 . (canceled)
2 . A method of treating scar tissue, the method comprising:
providing an individual having scar tissue;
forming a wound in the scar tissue, the wound including a plurality of epidermal cells located about the wound, thereby forming a wound edge;
contacting the wound edge with a therapeutically effective amount of a sustained release composition comprising tropoelastin,
wherein the sustained release composition is in contact with the wound edge for a time period to promote re-epithelization of the wound,
wherein the re-epithelialization of the wound treats the scar tissue.
3 . The method of claim 1 , wherein the scar tissue is treated by removal of the scar tissue.
4 . The method of claim 1 , wherein the scar tissue is treated by reducing a volume of the scar tissue.
5 . The method of claim 1 , wherein the wound is created by forming a plurality of micro punctures along the scar tissue to create multiple wounds in the scar tissue.
6 . The method of claim 1 , wherein the time period is no more than about 1 to 2 weeks.
7 . The method of claim 1 , wherein the time period is about 1 to 3 weeks.
8 . The method of claim 1 , wherein the sustained release composition comprising tropoelastin is a gel.
9 . The method of claim 7 , wherein the gel enables sustained release of the tropoelastin.
10 . The method of claim 7 , wherein the gel is a cross-linked hyaluronic acid gel.
11 . The method of claim 1 , wherein the tropoelastin is in the form of tropoelastin monomers.
12 . The method of claim 10 , wherein the tropoelastin monomers are not crosslinked.
13 . The method of claim 1 , wherein the sustained release composition comprises about 0.1 mg/mL to about 250 mg/mL of tropoelastin.
14 . The method of claim 12 , wherein the sustained release composition comprises about 25 mg/mL to about 50 mg/mL of tropoelastin.
15 . A method of treating scar tissue, the method comprising:
providing an individual having scar tissue,
forming a wound in the scar tissue,
contacting the wound with a therapeutically effective amount of a composition comprising tropoelastin and hyaluronic acid for a time period to promote re-epithelization of the wound.
16 . The method of claim 14 , wherein the wound is created surgically.
17 . The method of claim 15 , wherein the wound is created by forming a plurality of micro punctures along the scar tissue to create multiple wounds in the scar tissue.
18 . The method of claim 14 , wherein the tropoelastin is present in the composition in an amount of about 25 mg/mL to about 50 mg/mL.
19 . The method of claim 14 , wherein the tropoelastin is in the form of tropoelastin monomers.
20 . The method of claim 18 , wherein the tropoelastin monomers are not crosslinked.
21 . The method of claim 14 , wherein hyaluronic acid is crosslinked.