Quinolines that modulate SERCA and their use for treating disease
Provided herein are compounds of Formula I, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of a neurological disease, neurodegenerative disorder, or diabetes.
1. A pharmaceutical composition comprising a compound, or a pharmaceutically acceptable salt, solvate, or hydrate thereof, and a pharmaceutically acceptable carrier or diluent, wherein the compound is selected from:
wherein the pharmaceutical composition is a solid form.
2. The pharmaceutical composition of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt, solvate, or hydrate thereof.
3. The pharmaceutical composition of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt, solvate, or hydrate thereof.
4. The pharmaceutical composition of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt, solvate, or hydrate thereof.
5. A method for treating one or more symptoms of diabetes in a subject in need thereof comprising administering to the subject an effective amount of the pharmaceutical composition of claim 1 .
6. A method for treating one or more symptoms of diabetes in a subject in need thereof comprising administering to the subject an effective amount of a compound, or a pharmaceutically acceptable salt thereof, wherein the compound is:
or a pharmaceutically acceptable salt, solvate, or hydrate thereof.
7. The method of claim 5 , wherein the compound is
or a pharmaceutically acceptable salt, solvate, or hydrate thereof.
8. The method of claim 5 , wherein the compound is
or a pharmaceutically acceptable salt, solvate, or hydrate thereof.