IP Library Granted Patent US 12,097,073
Granted Patent B2
US 12,097,073 · App. 17/403,741 · Granted Sep 24, 2024

Systems and methods for determining clinical indications

Inventors: Robert Hamilton (Los Angeles, CA); Michael O'Brien (Los Angeles, CA); Leo Petrossian (Los Angeles, CA); Shankar Radhakrishnan (Los Angeles, CA); Corey Thibeault (Los Angeles, CA); Seth Wilk (Los Angeles, CA); Jan Zwierstra (Los Angeles, CA)
Assignee: Neurasignal, Inc.
A61B8/4218A61B5/024A61B5/4064A61B8/06A61B8/0808A61B8/4444A61B8/488A61B8/5223A61B8/4227A61B8/429A61B8/4483A61B8/5207A61B34/30
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Quick Facts
Patent No.
US 12,097,073
App. No.
17/403,741
Granted
Sep 24, 2024
Kind
B2
Abstract

According to various embodiments, there is provided a method for determining a neurological condition of a subject using a robotic system. The robotic system includes a transducer. The method includes determining, by a computing system, a first location with respect to a vessel of the subject, the robotic system configured to position the transducer at the first location. The method further includes receiving, by the computing system, a first signal from the vessel in response to the transducer transmitting acoustic energy towards the vessel. The method further includes analyzing, by the computing system, the received first signal to determine a first parameter of blood flow in the vessel. The method further includes determining, by the computing system, the neurological condition of the subject based on the first parameter of the blood flow in the vessel.

Claims (59)

1. A method for creating a mapped image of a blood vessel of a subject using a robotic system comprising a transducer, the method comprising:

determining, by a computing system, a first location of the transducer with respect to the blood vessel of the subject, the robotic system configured to position the transducer to the first location;

receiving, by the computing system, a first signal from the transducer at the first location in response to the transducer transmitting acoustic energy towards the blood vessel;

analyzing, by the computing system, the received first signal to determine a first parameter of blood flow in the blood vessel;

determining an error estimate using the first parameter;

determining a step size using the error estimate, wherein the step size varies based on the error estimate;

determining, by the computing system based on the first signal and the step size, a second location of the transducer with respect to the blood vessel;

moving, by the robotic system, the transducer to the second location with respect to the blood vessel;

receiving, by the computing system, a second signal from the blood vessel in response to the transducer transmitting the acoustic energy towards the blood vessel; and

creating, by the computing system, a mapped image of the blood vessel based on the first signal and the second signal.

2. The method of claim 1 , further comprising, accessing, by the computing system, a database including known blood vessel location information of subjects having similar characteristics as those of the subject, wherein the known blood vessel location information is used in creating the mapped image of the blood vessel of the subject.

3. The method of claim 2 , wherein the similar characteristics include similar demographic characteristics.

4. The method of claim 1 , wherein the second location is different from the first location.

5. The method of claim 1 , further comprising:

analyzing, by the computing system, the received second signal to determine a second parameter of blood flow in the blood vessel; and

creating the mapped image of the blood vessel based on the first signal and the second signal comprises creating the mapped image of the blood vessel based on the first parameter and the second parameter.

6. The method of claim 1 , wherein the mapped image comprises positional information of the blood vessel and blood flow information of the blood vessel.

7. The method of claim 1 , wherein the mapped image comprises an ultrasound image of the blood vessel.

8. The method of claim 1 , further comprising, accessing, by the computing system, a database including known blood vessel location information of the subject, wherein the known blood vessel location information is used in creating the mapped image of the blood vessel.

9. The method of claim 1 , further comprising, accessing, by the computing system, a database including known blood vessel location information of the subject, wherein the known blood vessel location information is used to determine the first location with respect to the blood vessel.

10. The method of claim 1 , wherein the first signal comprises information with respect to a plurality of depths of the blood vessel received simultaneously in the first signal.

11. The method of claim 1 ,

wherein the second location of the transducer is determined based on the first signal, the step size, and a direction; and

the second location is the step size in the direction from the first location.

12. A non-transitory computer-readable medium comprising computer-readable instructions, such that, when executed by a processor, causes the processor to:

determine a first location of a transducer with respect to a blood vessel of a subject, wherein a robotic system is configured to position the transducer to the first location;

receive a first signal from the transducer at the first location in response to the transducer transmitting acoustic energy towards the blood vessel;

analyze the received first signal to determine a first parameter of blood flow in the blood vessel;

determine an error estimate using the first parameter;

determine a step size using the error estimate, wherein the step size varies based on the error estimate;

determine, based on the first signal and the step size, a second location of the transducer with respect to the blood vessel;

move the transducer to the second location with respect to the blood vessel;

receive a second signal from the blood vessel in response to the transducer transmitting the acoustic energy towards the blood vessel; and

create a mapped image of the blood vessel based on the first signal and the second signal.

13. The non-transitory computer-readable medium of claim 12 , wherein the processor is further caused to access, a database including known blood vessel location information of subjects having similar characteristics as those of the subject, wherein the known blood vessel location information is used in creating the mapped image of the blood vessel of the subject.

14. The non-transitory computer-readable medium of claim 13 , wherein the similar characteristics include similar demographic characteristics.

15. The non-transitory computer-readable medium of claim 12 , wherein the processor is further caused to access a database including known blood vessel location information of the subject, wherein the known blood vessel location information is used in creating the mapped image of the blood vessel.

16. The non-transitory computer-readable medium of claim 12 , wherein the processor is further caused to access a database including known blood vessel location information of the subject, wherein the known blood vessel location information is used to determine the first location with respect to the blood vessel.

17. The non-transitory computer-readable medium of claim 12 , wherein

the second location of the transducer is determined based on the first signal, the step size, and a direction; and

the second location is the step size in the direction from the first location.

18. A robotic system for creating a mapped image of a blood vessel of a subject, the robotic system comprising:

a transducer;

control and signal processing logic configured to control positioning of the transducer and process signals received by the transducer, the control and signal processing logic configured to:

determine a first location of the transducer with respect to the blood vessel of the subject, the robotic system configured to position the transducer to the first location;

receive a first signal from the transducer at the first location in response to the transducer transmitting acoustic energy towards the blood vessel;

analyze the received first signal to determine a first parameter of blood flow in the blood vessel;

determine an error estimate using the first parameter;

determine a step size using the error estimate, wherein the step size varies based on the error estimate;

determine, based on the first signal and the step size, a second location of the transducer with respect to the blood vessel;

move the transducer to the second location with respect to the blood vessel;

receive a second signal from the blood vessel in response to the transducer transmitting the acoustic energy towards the blood vessel; and

create a mapped image of the blood vessel based on the first signal and the second signal.

19. The robotic system of claim 18 , the control and signal processing logic is further configured to:

analyzing the received second signal to determine a second parameter of blood flow in the blood vessel; and

creating the mapped image of the blood vessel based on the first signal and the second signal comprises creating the mapped image of the blood vessel based on the first parameter and the second parameter.

20. The robotic system of claim 18 ,

wherein the second location of the transducer is determined based on the first signal, the step size, and a direction; and

the second location is the step size in the direction from the first location.

Assignments (8)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 24, 2024
From: HAMILTON, ROBERT; O'BRIEN, MICHAEL; PETROSSIAN, LEO; RADHAKRISHNAN, SHANKAR; THIBEAULT, COREY; WILK, SETH; ZWIERSTRA, JAN
To: NEURAL ANALYTICS, INC.
Reel/Frame 067520/0943 →
CHANGE OF NAME Recorded May 24, 2024
From: NEURAL ANALYTICS, INC.
To: NOVASIGNAL CORP.
Reel/Frame 067529/0604 →
DEFAULT Recorded Mar 5, 2024
From: NOVASIGNAL CORP.
To: AVENUE VENTURE OPPORTUNITIES FUND, L.P.
Reel/Frame 066741/0678 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 10, 2023
From: AVENUE VENTURE OPPORTUNITIES FUND, L.P.
To: NEURASIGNAL, INC.
Reel/Frame 064238/0383 →
SECURITY INTEREST Recorded Jul 5, 2023
From: NEURASIGNAL, INC.
To: AVENUE CAPITAL MANAGEMENT II, L.P.
Reel/Frame 064155/0854 →
STATEMENT OF FORECLOSURE Recorded Jul 5, 2023
From: NOVASIGNAL CORP.
To: AVENUE VENTURE OPPORTUNITIES FUND, L.P.
Reel/Frame 064206/0484 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 5, 2023
From: AVENUE VENTURE OPPORTUNITIES FUND, L.P.
To: NEURASIGNAL, INC.
Reel/Frame 064155/0787 →
SECURITY INTEREST Recorded Dec 18, 2021
From: NOVASIGNAL CORP.
To: AVENUE VENTURE OPPORTUNITIES FUND, L.P.
Reel/Frame 058425/0481 →
Continuity (3)
Continuation 15399710 · Jan 5, 2017
Provisional Application 62275192 · Jan 5, 2016
Related Publication 20220218305A1 · Jul 14, 2022