IP Library › Granted Patent US 12,420,103
Granted Patent B1
US 12,420,103 · App. 17/405,721 · Granted Sep 23, 2025

Neurostimulation leads with reduced current leakage

Inventors: Henry Lee (Irvine, CA); Prabodh Mathur (Laguna Niguel, CA); Guangqiang Jiang (Irvine, CA)
Assignee: Axonics, Inc.
A61N1/3752A61N1/05A61N1/36142B29C45/261B29K2075/00
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Quick Facts
Patent No.
US 12,420,103
App. No.
17/405,721
Granted
Sep 23, 2025
Kind
B1
Abstract

Embodiments include implantable neurostimulation leads configured to reduce current leakage following implantation in a patient's body, and methods of manufacturing such leads. A lead includes a lead body with proximal apertures and distal apertures; a lumen extending through the lead body; electrodes at a distal portion of the lead body and connector interfaces at a proximal portion of the lead body; conductors extending through the lead body, with their proximal ends exiting via respective proximal apertures to couple with a respective connector interfaces, and their distal ends exiting the interior of the lead body via respective distal apertures to couple with a respective electrodes; and an electrically nonconductive filler element for occupying gaps in the interior of the lead body resulting from the exit of conductors from the lead body.

Claims (44)

1. An implantable neurostimulation lead comprising:

a lead body having a proximal portion and a distal portion, wherein the lead body has one or more proximal apertures along the proximal portion and one or more distal apertures along the distal portion;

a lumen extending the length of the lead body;

one or more electrodes positioned along an exterior of the lead body at the distal portion of the lead body;

one or more connector interfaces positioned along the exterior of the lead body at the proximal portion of the lead body, each connector interface configured to engage with a respective connector of a pulse generator;

one or more conductors extending through an interior of the lead body, each of the conductors having a proximal end and a distal end, wherein the proximal end exits the interior of the lead body via a respective proximal aperture to couple with a respective connector interface, and wherein the distal end exits the interior of the lead body via a respective distal aperture to couple with a respective electrode, each conductor coupling a respective electrode with a respective connector interface; and

a multi-filar filler element comprising a plurality of coiled filars positioned to occupy at least a portion of one or more gaps in the interior of the lead body resulting from the exit of one or more of the one or more conductors from the lead body, wherein the first filler element comprises an electrically nonconductive material, wherein the number of filars decreases in the proximal direction at the distal portion of the lead body.

2. The implantable neurostimulation lead of claim 1 , wherein the one or more conductors are coiled around the lumen, and wherein the first multi-filar filler element is coiled around the lumen.

3. The implantable neurostimulation lead of claim 2 , wherein the one or more conductors are coiled around the lumen at a first pitch, and wherein the first multi-filar filler element is coiled around the lumen at a second pitch, the second pitch substantially the same as the first pitch.

4. The implantable neurostimulation lead of claim 2 , wherein the one or more conductors are coiled around the lumen at a first pitch, and wherein the first multi-filar filler element is coiled around the lumen at a second pitch, the second pitch being different from the first pitch.

5. The implantable neurostimulation lead of claim 1 , wherein the one or more electrodes comprises four electrodes and the one or more connector interfaces comprises four connector interfaces, and wherein the multi-filar filler element comprises up to three filars.

6. The implantable neurostimulation lead of claim 1 , wherein:

the one or more electrodes comprises a first electrode and a second electrode; and

the one or more conductors comprises a first conductor and a second conductor, wherein a distal end of the first conductor exits the interior of the lead body via a first distal aperture and a distal end of the second conductor exits the interior of the lead body via a second distal aperture, the first distal aperture being distal to the second distal aperture;

wherein the multi-filar filler element is sized to extend between the first distal aperture and the second distal aperture along the interior of the lead body, and wherein the multi-filar filler element is sized to extend between the second distal aperture and a subsequent distal aperture along the interior of the lead body.

7. The implantable neurostimulation lead of claim 1 , wherein:

the one or more connector interfaces comprises a first connector interface and a second connector interface; and

the one or more conductors comprises a first conductor and a second conductor, wherein a proximal end of the first conductor exits the interior of the lead body via a first proximal aperture and a proximal end of the second conductor exits the interior of the lead body via a second proximal aperture, the second proximal aperture being distal to the first proximal aperture;

wherein the multi-filar filler element is sized to extend between the first proximal aperture and the second proximal aperture along the interior of the lead body and wherein the multi-filar filler element is sized to extend between the second proximal aperture and a subsequent proximal aperture along the interior of the lead body.

8. The implantable neurostimulation lead of claim 1 , further comprising a second filler element is disposed at the proximal portion of the lead, the second filler element comprising an electrically nonconductive material.

9. The implantable neurostimulation lead of claim 1 , wherein the first multi-filar filler element comprises a polyurethane material.

10. The implantable neurostimulation lead of claim 9 , wherein the lead body comprises a polyurethane material.

11. The implantable neurostimulation lead of claim 1 , wherein the first multi-filar filler element comprises a solid extrusion.

12. The implantable neurostimulation lead of claim 1 , wherein the first multi-filar filler element comprises an adhesive or cured thermoplastic or thermoset polymer material that is configured to be injected into the at least one or more gaps in the interior of the lead body.

13. The implantable neurostimulation lead of claim 1 , wherein the first multi-filar filler element has a length of 10 to 60 mm.

14. The implantable neurostimulation lead of claim 1 , wherein the first multi-filar filler element has a diameter of 0.03 to 0.3 mm.

15. The implantable neurostimulation lead of claim 1 , wherein the first multi-filar filler element comprises a ribbon-like filar structure having a width of 0.01 to 2 mm.

16. An implantable neurostimulation lead comprising:

a lead body having a proximal portion and a distal portion;

a plurality of electrodes positioned in series along an exterior of the lead body at the distal portion of the lead body;

a plurality of conductors extending through an interior of the lead body, each of the conductors having a proximal end and a distal end, wherein the distal end of each conductor terminates due to each of the electrodes coupling with one of the plurality of electrodes; and

a multi-filar filler element comprising plurality of coiled filars positioned to occupy a distal gap in the interior of the distal portion of the lead body created by the termination of the plurality of conductors, and wherein the volume to be filled by the filler element in the distal portion of the lead body increases along the length of the lead in a distal direction due to the increasing size of the distal gap resulting from the sequential termination of the electrodes, and wherein the number of filars decreases in the proximal direction at the distal portion of the lead body.

17. The implantable neurostimulation lead of claim 16 , wherein each of the plurality of conductors are coiled around a lumen, and wherein the filler element is coiled around the lumen.

18. The implantable neurostimulation lead of claim 17 , wherein each of the plurality of conductors are coiled around the lumen at a first pitch, and wherein the filler element is coiled around the lumen at a second pitch, and wherein the second pitch is different from the first pitch.

19. The implantable neurostimulation lead of claim 16 , wherein the filler element is injected into the distal portion of the lead body.

20. An implantable neurostimulation lead comprising:

a lead body having a proximal portion and a distal portion;

a plurality of electrodes positioned along an exterior of the lead body at the distal portion of the lead body;

a plurality of connector interfaces positioned in series along the exterior of the lead body at the proximal portion of the lead body, each connector interface configured to engage with a respective connector of a pulse generator;

a plurality of conductors extending through an interior of the lead body, each of the conductors having a proximal end and a distal end, wherein the proximal end of each conductor is coupled with one of the plurality of connector interfaces; and

a multi-filar filler element comprising a plurality of coiled filars positioned to occupy a proximal gap in the interior of the distal portion of the lead body created by the coupling of the proximal end of each of the plurality of conductors with one of the plurality of connector interfaces, and wherein the volume to be filled by the filler element in the proximal portion of the lead body decreases along the length of the lead in a distal direction due to the decreasing size of the proximal gap resulting from the sequential coupling of the electrodes with the connector interface, and wherein the number of filars decrease in the distal direction at the proximal portion of the lead body.

21. The implantable neurostimulation lead of claim 20 , wherein each of the plurality of conductors are coiled around a lumen, and wherein the filler element is coiled around the lumen.

22. The implantable neurostimulation lead of claim 21 , wherein each of the plurality of conductors are coiled around the lumen at a first pitch, and wherein the filler element is coiled around the lumen at a second pitch, and wherein the second pitch is different from the first pitch.

23. The implantable neurostimulation lead of claim 20 , wherein the filler element is injected into the proximal portion of the lead body.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 12, 2024
From: LEE, HENRY; MATHUR, PRABODH; JIANG, GUANGQIANG
To: AXONICS, INC.
Reel/Frame 068880/0854 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 22, 2021
From: LEE, HENRY; MATHUR, PRABODH; JIANG, GUANGQIANG
To: AXONICS, INC.
Reel/Frame 058179/0532 →
Continuity (1)
Provisional Application 63068299 · Aug 20, 2020
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