CD19-targeted chimeric antigen receptor and use thereof
A chimeric antigen receptor, comprising an amino acid sequence shown in SEQ ID NO. 1. A nucleic acid encoding the chimeric antigen receptor, a vector comprising the nucleic acid, an immune effector cell comprising the chimeric antigen receptor, the nucleic acid molecule and/or the vector, a method for preparing the immune effector cell, a composition comprising the immune effector cell, and use of the chimeric antigen receptor.
1. A chimeric antigen receptor, consisting of the amino acid sequence of in SEQ ID NO. 1.
2. An immune effector cell comprising the chimeric antigen receptor according to claim 1 .
3. The immune effector cell according to claim 2 , wherein the immune effector cell is selected from the group consisting of a T lymphocytes and a natural killer cell.
4. A composition, comprising the immune effector cell according to claim 2 .
5. The composition according to claim 4 , further comprising one or more formulations of carriers, stabilizers, excipients, diluents, solubilizers, surfactants, emulsifiers and preservatives.
6. The composition according to claim 4 , wherein the composition is present in a liquid, frozen, or lyophilized form.
7. The composition according to claim 4 , wherein the immune effector cell is selected from the group consisting of a T lymphocyte and a natural killer cell.
8. The composition according to claim 4 , wherein a chimeric antigen receptor consisting of the amino acid sequence of SEQ ID NO. 1 is expressed on the surface of the immune effector cell.