IP Library › Granted Patent US 12,644,096
Granted Patent B2
US 12,644,096 · App. 17/413,179 · Granted Jun 2, 2026

Method for increasing romidepsin production from fermentation broth

Inventors: Gian Oddone (Davis, CA); Jacob Blodgett (Davis, CA); Raul Reveles (Davis, CA)
Assignee: PRO FARM GROUP, INC.
C12N1/38C07K5/101C12N1/20
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Quick Facts
Patent No.
US 12,644,096
App. No.
17/413,179
Granted
Jun 2, 2026
Kind
B2
Abstract

The present invention includes a method to increase romidepsin concentration in a bacteria fermentation media. Romidepsin concentration in a fermentation is increased by adding, for example, copper sulfate. The end resulting romidepsin concentration is increased by at least about two fold as compare to fermentation without copper sulfate.

Claims (2)

1 . A method of increasing romidepsin concentration in a bacterial fermentation comprising:

fermenting a Chromobacterium haemolyticum or Burkholderia rinojensis bacterial strain in a fermentation medium comprising 0.1 g/L copper (II) sulfate, wherein said copper (II) sulfate increases romidepsin production compared to a fermentation that is identical but without the copper (II) sulfate in the medium.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 28, 2026
From: WILMINGTON SAVINGS FUND SOCIETY, FSB
To: PFG HOLDING CORPORATION
Reel/Frame 075495/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 20, 2021
From: ODDONE, GIAN; BLODGETT, JACOB; REVELES, RAUL
To: MARRONE BIO INNOVATIONS, INC.
Reel/Frame 056916/0001 →
Continuity (3)
Provisional Application 62904124 · Sep 23, 2019
Provisional Application 62784656 · Dec 24, 2018
Related Publication 20220049213A1 · Feb 17, 2022
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