Neurostimulation device for blocking blood flow between electrodes
A neurostimulation device 1 for non-destructively stimulating neural activity in a nerve 3 in proximity to a blood vessel 5. The neurostimulation device 1 comprises a catheter 7 for insertion into the blood vessel 5; a proximal electrode 11 offset from a distal electrode 9 along a length of the catheter 7; and an insulator 13 positioned between the proximal electrode 11 and the distal electrode 9 on the catheter 7. The insulator 13 has a contracted configuration in which the size of the insulator 13 allows the catheter 7 to travel inside the blood vessel 5. The insulator 13 has an expanded configuration in which the insulator 13 blocks blood flowing through the blood vessel between the proximal electrode 11 and the distal electrode 9. The neurostimulation device 1 comprises a stimulator 15 arranged to apply an electrical signal between the proximal electrode 11 and the distal electrode 9 when the insulator 13 is in the expanded configuration, thus inducing electrical activity in a wall portion of the blood vessel between the proximal and distal electrodes 9, 11. There is also an insulation portion between the distal electrode 9 and a distal end of the catheter 7 for offsetting the distal electrode 9 from a wall of the blood vessel 5.
1. A neurostimulation device for non-destructively stimulating neural activity in a nerve in proximity to a blood vessel for treating an acute medical condition or inflammatory disorder, the neurostimulation device comprising:
an indwelling device capable of insertion into a blood vessel and configured to be placed inside the blood vessel for stimulating the nerve; and
a proximal electrode offset from a distal electrode along a length of the indwelling device, wherein the proximal electrode is an anode electrode and has a larger surface area than the distal electrode, an insulator positioned between the proximal electrode and the distal electrode on the indwelling device, wherein the insulator is positioned closer to the proximal electrode than the distal electrode, such that the insulator keeps the proximal electrode in a central location approximately equal around the inside circumference of the blood vessel, and wherein the electrodes are configured to apply a non-destructive electrical signal to the nerve and connectable to a stimulator, wherein the non-destructive electrical signal for stimulating the nerve comprises a pulse train having a pulse width ≥0.1 ms and ≤5 ms and wherein the non-destructive electrical signal propagates an action potential distally towards an organ and produces an improvement in a physiological parameter in a subject, and wherein the improvement in the physiological parameter is one or more of a group consisting of: stabilization of blood pressure, prevention of an inflammatory response, suppression of an inflammatory response, or reduction in an inflammatory response.
2. The neurostimulation device of claim 1 , wherein the pulse train has an interphase delay of delay of ≤0.3 ms and ≥0.1 ms.
3. The neurostimulation device of claim 1 , wherein the charge density per phase applied to the nerve by the non-destructive electrical signal is ≥20 μC per cm 2 per phase and ≤850 μC per cm 2 per phase.
4. The neurostimulation device of claim 1 , wherein the charge density per phase applied to the nerve by the non-destructive electrical signal is ≥20 μC per cm 2 per phase and ≤4000 μC per cm 2 per phase.
5. The neurostimulation device of claim 1 , wherein the proximal electrode is offset from the distal electrode by a minimum spacing of 1.5 cm along the length of the indwelling device.
6. The neurostimulation device of claim 1 , wherein the proximal electrode is offset from the distal electrode by a maximum spacing of 4 cm along the length of the indwelling device.
7. The neurostimulation device of claim 1 , wherein the proximal electrode is offset from the distal electrode by a spacing of 2 cm along the length of the indwelling device.
8. The neurostimulation device of claim 1 , wherein the proximal electrode is an anode electrode during the stimulation phase of a bipolar pulse and wherein the anode is at least 1 cm in length.
9. The neurostimulation device of claim 1 , wherein the proximal electrode and/or the distal electrode is coated in Titanium Nitride, Iridium Oxide, PEDOT or Platinum Grey.
10. The neurostimulation device of claim 1 , wherein the distal electrode has a surface area of between 0.01 cm 2 and 0.1 cm 2 .
11. The neurostimulation device of claim 1 , further comprising a second insulator positioned between the distal electrode and the distal end of the indwelling device.
12. The neurostimulation device of claim 1 , wherein the neurostimulation device is configured to be placed inside the splenic artery for stimulating a splenic nerve.
13. The neurostimulation device of claim 1 , wherein the insulator has a contracted configuration in which the size of the insulator allows the indwelling device to travel inside the blood vessel;
the insulator has an expanded configuration in which the insulator blocks blood flowing through the blood vessel between the proximal electrode and the distal electrode;
the stimulator is configured to apply an electrical signal between the proximal electrode and the distal electrode when the insulator is in the expanded configuration, thus inducing electrical activity in a wall portion of the blood vessel between the proximal and distal electrodes; and
an insulation portion between the distal electrode and a distal end of the indwelling device for offsetting the distal electrode from the wall of the blood vessel.
14. The neurostimulation device of claim 1 , wherein the non-destructive electrical signal for stimulating the nerve comprises a pulse train having a pulse width >1 ms and ≤5 ms.