External composition
The present disclosure provides an external composition containing lidocaine, a cool feeling agent, and vanillyl butyl ether.
1. An external composition comprising lidocaine, a cool feeling agent, and vanillyl butyl ether, wherein
the external composition has 2% or more by weight of lidocaine,
the cool feeling agent comprises I-menthol,
the amount of I-menthol is 62.5 to 100 parts by weight based on 100 parts by weight of lidocaine,
the amount of vanillyl butyl ether is 4 to 6 parts by weight based on 100 parts by weight of I-menthol,
the composition comprises 50 to 90% by weight of water, and
the composition comprises a gel substrate.
2. The external composition according to claim 1 , wherein the cool feeling agent is I-menthol.
3. The external composition according to claim 1 , comprising 0.01 to 10% by weight of the cool feeling agent.
4. The external composition according to claim 1 , comprising 0.005 to 1.0% by weight of vanillyl butyl ether.
5. The external composition according to claim 1 , wherein the ratio of the cool feeling agent to vanillyl butyl ether is 1:0.001 to 1:0.4.
6. The external composition according to claim 1 , comprising 2 to 10% by weight of lidocaine.
7. The external composition according to claim 1 , comprising aluminum hydroxide, sodium polyacrylate, polyacrylic acid and polyvinyl alcohol as the gel substrate.
8. A patch comprising a composition layer comprising the external composition according to claim 1 , the composition layer being stacked on a support.
9. The patch according to claim 8 , wherein the support is a nonwoven fabric.
10. The patch according to claim 8 , wherein the composition layer has a maximum thickness of 0.5 mm or more.
11. An external composition comprising lidocaine, a cool feeling agent, and vanillyl butyl ether, wherein
the cool feeling agent has 2.5 to 10% by weight of I-menthol,
the amount of I-menthol is 62.5 to 100 parts by weight based on 100 parts by weight of lidocaine,
the amount of vanillyl butyl ether is 4 to 6 parts by weight based on 100 parts by weight of I-menthol,
the composition comprises 50 to 90% by weight of water, and
the composition comprises a gel substrate.
12. An external composition comprising lidocaine,
a cool feeling agent,
vanillyl butyl ether,
less than 0.05% by weight methylparaben, and
less than 0.02% by weight propylparaben, wherein
the cool feeling agent comprises I-menthol,
the amount of I-menthol is 62.5 to 100 parts by weight based on 100 parts by weight of lidocaine,
the amount of vanillyl butyl ether is 4 to 6 parts by weight based on 100 parts by weight of I-menthol,
the composition comprises 50 to 90% by weight of water, and
the composition comprises a gel substrate.
13. The external composition according to claim 1 , comprising 0.01 to 5% by weight of the cool feeling agent.
14. The external composition according to claim 1 , comprising 0.01 to 0.5% by weight of vanillyl butyl ether.
15. The external composition according to claim 1 , wherein the ratio of the cool feeling agent to vanillyl butyl ether is 1:0.001 to 1:0.2.
16. The external composition according to claim 1 , wherein the ratio of the cool feeling agent to vanillyl butyl ether is 1:0.001 to 1:0.1.
17. The external composition according to claim 1 , wherein the ratio of the cool feeling agent to vanillyl butyl ether is 1:0.01 to 1:0.1.