Antimicrobial compositions with 1,2-alkanediols
Compositions including a quaternary amine antiseptic component having a concentration of at least about 0.04% by weight; a poly carboxylic acid chelator having a concentration of at least about 0.05 M and/or an alphahydroxy acid buffer having a concentration of at least about 0.05 M; a (C8-C12) 1,2 alkane diol; and optionally water are provided. The compositions have a pH greater than or equal to 3.5 and less than 5.5 at 23° C. In certain embodiments, water is present in the composition at a greater weight percent than each of the quaternary amine antiseptic component; the polycarboxylic acid chelator, if present; the alphahydroxy acid buffer, if present; and the (C8-C12) 1,2-alkane diol. In certain embodiments, water is present in the composition at a greater weight percent than any other component.
1. An antiseptic composition, comprising:
a quaternary ammonium antiseptic component present in an amount of at least 0.04% by weight, the quaternary ammonium antiseptic component being a benzalkonium halide;
a polycarboxylic acid chelator of one or more of citric acid and citrate present in a concentration of at least 0.05 M;
a (C8-C12) 1,2 alkane diol; and
water;
wherein the antiseptic composition is characterized by a pH that is greater than or equal to 3.5 and less than 5.5 at 23° C.;
wherein the water is present in the antiseptic composition at a greater weight percent than each of the quaternary ammonium antiseptic component, the polycarboxylic acid chelator, and the (C8-C12) 1,2-alkane diol.
2. The antiseptic composition of claim 1 , wherein the quaternary ammonium antiseptic component is a benzalkonium chloride.
3. The antiseptic composition of claim 1 , further comprising a betahydroxy acid.
4. The antiseptic composition of claim 3 , wherein the betahydroxy acid is selected from the group consisting of betahydroxypropionic acid, salicylic acid, betahydroxybutanoic acid, tropic acid, and trethocanic acid.
5. The antiseptic composition of claim 1 , wherein the quaternary ammonium antiseptic component is present in an amount of up to 1.0% by weight.
6. The antiseptic composition of claim 1 , wherein the polycarboxylic acid chelator is present in an amount of 0.5% to 25% by weight.
7. The antiseptic composition of claim 1 , wherein the (C8-C12) 1,2 alkane diol is present in an amount of 0.05% by weight to 3% by weight.
8. The antiseptic composition of claim 1 , wherein the (C8-C12) 1,2 alkane diol is 1,2-octane diol.
9. The antiseptic composition of claim 1 , characterized by a pH that is greater than or equal to 3.8 and less than 5.0 at 23° C.
10. The antiseptic composition of claim 1 , further comprising an alphahydroxy acid.
11. The antiseptic composition of claim 10 , wherein the alphahydroxy acid is selected from a group consisting of mandelic acid or a salt thereof, gluconic acid or a salt thereof, gluconolactone, glycolic acid or a salt thereof, lactic acid or a salt thereof, and a combination thereof.
12. The antiseptic composition of claim 10 , wherein the alphahydroxy acid is present in an amount of up to 10% by weight.
13. A method of treating a wound, the method comprising applying the antiseptic composition of claim 1 to a wound site.
14. An antiseptic composition, comprising:
a quaternary amine antiseptic component present in an amount of at least 0.04% by weight, the quaternary amine antiseptic component being a benzalkonium halide;
a polycarboxylic acid chelator of one or more of citric acid and citrate present in a concentration of at least 0.05 M;
a (C8-C12) 1,2 alkane diol; and
water present in an amount from 0% to 75% by weight;
wherein when the antiseptic composition is characterized by a pH that is greater than or equal to 3.5 and less than 5.5 at 23° C. when the antiseptic composition comprises <50% water by weight.
15. An antiseptic composition, comprising:
a quaternary amine antiseptic component present in an amount of at least 0.04% by weight, the quaternary amine antiseptic component being a benzalkonium halide;
a polycarboxylic acid chelator of one or more of citric acid and citrate present in a concentration of at least 0.05 M;
a (C8-C12) 1,2 alkane diol; and
water;
wherein the antiseptic composition is characterized by a pH that is greater than or equal to 3.5 and less than 5.5 at 23° C.;
wherein the water is present in the antiseptic composition at a greater weight percent than any other component of the antiseptic composition.