Production and Use of Yeast Extract as a Medical Adjuvant
The present invention relates to compositions and methods for enhancing bioavailability of health-promoting compounds, such as pharmaceuticals and nutritional supplements. The subject invention utilizes an adjuvant composition comprising yeast extract to enhance bioavailability of health-promoting compounds and to reduce the effective dosage that is required.
1 . A method for enhancing the bioavailability of a health-promoting compound, the method comprising: administering to the subject a therapeutically-effective amount of an adjuvant composition comprising yeast extract, and a therapeutically-effective amount of the health-promoting compound.
2 . The method of claim 1 , wherein the yeast extract comprises proteins, nucleic acids, amino acids, peptides, carbohydrates and/or metabolites produced by the yeast during cultivation thereof.
3 . The method of claim 1 , wherein the health-promoting compound and the adjuvant composition are administered to a subject through a route selected from oral, intravenous, rectal, vaginal, ocular, transdermal, aural, nasal, mucosal, inhalation and cutaneous.
4 . The method of claim 1 , used to enhance penetration of the health-promoting compound into epithelial cells in the subject's gastrointestinal tract.
5 . The method of claim 1 , used to enhance penetration of the health-promoting compound across the subject's blood-brain barrier.
6 . The method of claim 1 , used to reduce the amount of the health-promoting compound that is required for it to be therapeutically-effective in the subject.
7 . The method of claim 1 , wherein the yeast extract is produced by: a) cultivating Saccharomyces cerevisiae yeast cells in a nutrient medium comprising one or more oils comprising a saturated fatty acid as a carbon source to produce a desired cell density; b) inactivating the yeast cells to produce a hydrolysate; c) centrifuging the hydrolysate to produce a supernatant and a pellet, the pellet comprising yeast cell walls, and d) removing the pellet,
wherein the supernatant comprises the yeast extract.
8 . The method of claim 7 , wherein the one or more oils are vegetable oil, sunflower oil, soybean oil, peanut oil or coconut oil.
9 . The method of claim 7 , further comprising concentrating the yeast extract using a rotary evaporator operated at a temperature of 50° C. to 70° C.
10 . The method of claim 7 , further comprising drying the yeast extract.
11 . The method of claim 1 , wherein the adjuvant composition further comprises a pharmaceutically-acceptable carrier.
12 . The method of claim 1 , wherein the adjuvant composition and the health-promoting compound are mixed together as one formulation when administered to the subject.
13 . The method of claim 12 , wherein the adjuvant composition and the health-promoting compound are encapsulated together into a capsule, nanocapsule or liposome delivery system.
14 . The method of claim 1 , wherein the adjuvant composition is administered to the subject as a separate composition from the health-promoting compound.
15 . The method of claim 1 , wherein the health-promoting compound is a pain-reliever, antihistamine, antiviral, anticancer and/or chemotherapeutic compound, antibiotic, antimicrobial, antiseizure compound, anti-inflammatory compound, vaccine, statin, hormone, antidepressant, vitamin, mineral, nutrient or water.
16 . The method of claim 1 , wherein the health-promoting compound is cannabidiol (CBD).
17 . A composition comprising an adjuvant and a health-promoting compound, said adjuvant comprising yeast extract of S. cerevisiae.
18 . The composition of claim 17 , wherein the health-promoting compound is a pain-reliever, antihistamine, antiviral, anticancer and/or chemotherapeutic compound, antibiotic, antimicrobial, antiseizure compound, anti-inflammatory compound, vaccine, statin, hormone, antidepressant, vitamin, mineral, nutrient or water.
19 . The composition of claim 17 , wherein the health-promoting compound is cannabidiol (CBD).