Granted Patent
B2
US 11,753,398 · App. 17/459,598 · Granted Sep 12, 2023
Therapeutic compounds
Assignee:
C4X Discovery Limited
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Abstract
The present invention relates to compounds that are antagonists of the orexin-1 receptor. The compounds have the structural formula (I) defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with orexin-1 receptor activity.
Claims (4)
1. (2S)-N 2 -methyl-N 1 -(5-(trifluoromethyl)pyrazin-2-yl)propane-1,2-diamine:
or a salt thereof.
2. The salt according to claim 1 , wherein the salt is the 1,3,5-benzenetricarboxylic acid (trimesic acid) salt:
3. (2S)-N 2 -benzyl-N 2 -methyl-N 1 -(5-(trifluoromethyl)pyrazin-2-yl)propane-1,2-diamine:
Assignments (5)
RELEASE OF SECURITY INTEREST
Recorded Mar 18, 2026
From: PIPER SANDLER FINANCE, LLC
To: INDIVIOR INC.; INDIVIOR UK LIMITED
Reel/Frame 074114/0582 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE NAME AND ADDRESS PREVIOUSLY RECORDED ON REEL 68342 FRAME 653. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT.
Recorded Sep 17, 2025
From: C4X DISCOVERY LIMITED
To: INDIVIOR UK LIMITED
Reel/Frame 073958/0904 →
SECURITY INTEREST
Recorded Nov 13, 2024
From: INDIVIOR INC.; INDIVIOR UK LIMITED
To: PIPER SANDLER FINANCE LLC, AS COLLATERAL AGENT
Reel/Frame 069254/0413 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 20, 2024
From: C4X DISCOVERY LIMITED
To: INDIVIOR UK LIMITED (CO.)
Reel/Frame 068342/0653 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 23, 2022
From: MARTIN, BARRIE P.
To: C4X DISCOVERY LIMITED
Reel/Frame 060868/0888 →