Antibody drug conjugates (ADCS) having enzymatically cleavable groups
The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases.
1. An antibody or antigen-binding antibody fragment that binds to CXCR5, comprising a variable heavy chain comprising the variable CDR1 sequence of the heavy chain as shown in SEQ ID NO: 92, the variable CDR2 sequence of the heavy chain as shown in SEQ ID NO: 93, and the variable CDR3 sequence of the heavy chain as shown in SEQ ID NO: 94; and a variable light chain comprising the variable CDR1 sequence of the light chain as shown in SEQ ID NO: 96, the variable CDR2 sequence of the light chain as shown in SEQ ID NO: 97, and the variable CDR3 sequence of the light chain as shown in SEQ ID NO: 98.
2. The antibody or antigen-binding antibody fragment of claim 1 , wherein the variable heavy chain comprises a sequence at least 98% identical to SEQ ID NO: 91.
3. The antibody or antigen-binding antibody fragment of claim 1 , wherein the variable heavy chain comprises SEQ ID NO: 91.
4. The antibody or antigen-binding antibody fragment of claim 1 , wherein the variable light chain comprises a sequence at least 98% identical to SEQ ID NO: 95.
5. The antibody or antigen-binding antibody fragment of claim 2 , wherein the variable light chain comprises a sequence at least 98% identical to SEQ ID NO: 95.
6. The antibody or antigen-binding antibody fragment of claim 3 , wherein the variable light chain comprises a sequence at least 98% identical to SEQ ID NO: 95.
7. The antibody or antigen-binding antibody fragment of claim 1 , wherein the variable light chain comprises SEQ ID NO: 95.
8. The antibody or antigen-binding antibody fragment of claim 2 , wherein the variable light chain comprises SEQ ID NO: 95.
9. The antibody or antigen-binding antibody fragment of claim 3 , wherein the variable light chain comprises SEQ ID NO: 95.
10. The antibody or antigen-binding antibody fragment of claim 1 , comprising a heavy chain comprising SEQ ID NO: 101.
11. The antibody or antigen-binding antibody fragment of claim 1 , comprising a light chain comprising SEQ ID NO: 105.
12. The antibody or antigen-binding antibody fragment of claim 10 , comprising a light chain comprising SEQ ID NO: 105.
13. A method for treatment of a disease associated with CXCR5 expression, comprising administering to a patient in need thereof an effective amount of the antibody or antigen-binding antibody fragment of claim 1 .
14. A method for treatment of a disease associated with CXCR5 expression, comprising administering to a patient in need thereof an effective amount of the antibody or antigen-binding antibody fragment of claim 9 .
15. A conjugate comprising the antibody or antigen-binding antibody fragment of claim 1 , and a chemotherapeutic.
16. The conjugate of claim 15 , wherein the chemotherapeutic comprises an inhibitor of kinesin spindle protein.
17. A method for treatment of a disease associated with CXCR5 expression, comprising administering to a patient in need thereof an effective amount of the conjugate of claim 16 .
18. A conjugate comprising the antibody or antigen-binding antibody fragment of claim 9 , and a chemotherapeutic.
19. The conjugate of claim 18 , wherein the chemotherapeutic comprises an inhibitor of kinesin spindle protein.
20. A method for treatment of a disease associated with CXCR5 expression, comprising administering to a patient in need thereof an effective amount of the conjugate of claim 19 .