Carbamoyl phenylalaninol compounds and uses thereof
The present invention relates to carbamoyl phenylalaninol compounds and methods of using the same to treat disorders.
1. A method of treating narcolepsy, cataplexy, excessive daytime sleepiness, drug addiction, sexual dysfunction, fatigue, fibromyalgia, restless legs syndrome, depression, bipolar disorder, or obesity in a subject in need thereof, or promoting smoking cessation in a subject in need thereof, comprising administering to the subject compound 1:
or a pharmaceutically acceptable salt thereof.
2. A method of inducing a pro-cognitive effect in a subject in need thereof, comprising administering to the subject compound 1:
or a pharmaceutically acceptable salt thereof;
wherein the subject has bipolar depression, major depressive disorder, PTSD, or Parkinson's Disease.
3. A method of treating nightmares and/or sleep-related disturbances associated with PTSD in a subject in need thereof, comprising administering to the subject compound 1:
or a pharmaceutically acceptable salt thereof.
4. The method of claim 1 , wherein the compound is compound 2:
or a pharmaceutically acceptable salt thereof.
5. The method of claim 1 , comprising administering a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier.
6. The method of claim 5 , wherein the composition is a dosage form.
7. The method of claim 6 , wherein the composition is an immediate release oral dosage form.
8. The method of claim 7 , wherein the composition is a tablet or a capsule.
9. The method of claim 2 , wherein the compound is compound 2:
or a pharmaceutically acceptable salt thereof.
10. The method of claim 2 , comprising administering a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier.
11. The method of claim 10 , wherein the composition is a dosage form.
12. The method of claim 11 , wherein the composition is an immediate release oral dosage form.
13. The method of claim 12 , wherein the composition is a tablet or a capsule.
14. The method of claim 3 , wherein the compound is compound 2:
or a pharmaceutically acceptable salt thereof.
15. The method of claim 3 , comprising administering a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier.
16. The method of claim 15 , wherein the composition is a dosage form.
17. The method of claim 16 , wherein the composition is an immediate release oral dosage form.
18. The method of claim 17 , wherein the composition is a tablet or a capsule.