ORAL COMPOSITION OF CELECOXIB FOR TREATMENT OF PAIN
The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or its pharmaceutically acceptable salts thereof. The celecoxib present in the compositions as described herein do not show any precipitation when subjected in Fasted-State Simulated Gastric Fluid (FaSSGF) at pH 2.0, temperature of 37° C.±0.5° C. and under stirring at a speed of 50 rpm at least for 60 minutes. It also relates to the process of preparing and method of using said composition of celecoxib.
1 . A stable oral liquid pharmaceutical composition comprising a therapeutically effective amount of celecoxib, at least one solubilizer, at least one medium chain glyceride, and at least one polar solvent, wherein said composition has a D50 oil droplet size of not more than about 250 nm upon being subjected to stability evaluation conditions of 40° C./75% RH for 3 months.
2 .- 36 . (canceled)