Pyrazine-containing compound
Compositions and methods related to the amelioration of pancreatitis through the pharmaceutical manipulation of calcium signaling are disclosed. Such compositions and methods may be used to ameliorate symptoms of acute or chronic pancreatitis or to reduce the chance or severity of pancreatitis in an individual at risk of the condition. In other embodiments, disclosed herein are compositions and methods related to the amelioration of viral diseases through the pharmaceutical manipulation of calcium signaling. In further embodiments, disclosed herein are compositions and methods related to the amelioration of Th17-induced diseases through the pharmaceutical manipulation of calcium signaling.
1. A method for treating renal failure in a subject, comprising administering to the subject a therapeutically effective amount of a compound having a chemical name of N-[5-(6-chloro-2,2-difluorobenzo[d]1,3-dioxolen-5-yl)pyrazin-2-yl](2-fluoro-6-methylphenyl)carboxamide or a pharmaceutically acceptable sale thereof, wherein the subject has renal failure as a secondary manifestation of pancreatitis resulting from an inflammatory response.
2. The method of claim 1 , wherein the renal failure is severe chronic renal failure.
3. The method of claim 1 , wherein the inflammatory response is a chronic inflammatory disease.
4. The method of claim 3 , wherein the chronic inflammatory disease is T helper 17 cell (Th 17) induced.
5. The method of claim 4 , wherein the Th17 induced chronic inflammatory disease is an autoimmune disorder.
6. The method of claim 1 , wherein the inflammatory response is associated with a group of inflammatory mediators consisting of TNF-α and IL-1.
7. The method of claim 5 , further comprising inhibiting Th17 differentiation.
8. The method of claim 1 , wherein the compound is administered to achieve a plasma level concentration that is about 1 μM.
9. The method of claim 1 , wherein the compound is administered to achieve a plasma level concentration that is from about 1 μM to about 2 μM.
10. The method of claim 1 , wherein the compound is administered to achieve a plasma level concentration that is about 5 μM.
11. A method for treating an autoimmune disease in a kidney in a subject, comprising administering to the subject a therapeutically effective amount of a compound having a chemical name of N-[5-(6-chloro-2,2-difluorobenzo[d]1,3-dioxolen-5-yl)pyrazin-2-y](2-fluoro-6-methylphenyl)carboxamide or a pharmaceutically acceptable sale thereof, wherein the autoimmune disease is Th17 induced.
12. The method of claim 11 , wherein the autoimmune disease in the kidney is associated with an inflammatory response in the subject.
13. The method of claim 12 , wherein the inflammatory response is a chronic inflammatory disease.
14. The method of claim 12 , wherein the inflammatory response is associated with a group of inflammatory mediators further consisting of TNF-α and IL-1.
15. The method of claim 11 , wherein the compound is administered to achieve a plasma level concentration that is about 1 μM.
16. The method of claim 11 , wherein the compound is administered to achieve a plasma level concentration that is from about 1μM to about 2μM.
17. The method of claim 11 , wherein the compound is administered to achieve a plasma level concentration that is about 5 μM.