IP Library › Granted Patent US 11,672,646
Granted Patent B2
US 11,672,646 · App. 17/473,571 · Granted Jun 13, 2023

Composite scaffold for the repair, reconstruction, and regeneration of soft tissues

Inventors: Kevin A. Rocco (New Haven, CT); Bhavana Mohanraj (Philadelphia, PA); Jeffrey Ott (New Haven, CT); Justin Bendigo (Reading, PA); Jacob Edward Komenda (New Haven, CT); Mark Theodore Aronson (Midlothian, VA); Andrew James Carter (Stow, MA)
Assignee: Biorez, Inc.
A61F2/08A61F2/0063A61L27/14A61L27/18A61L27/24A61L27/26A61L27/48A61L27/52A61L27/56A61L27/58D06N3/0043A61F2002/0068A61F2002/0081A61F2210/0004A61F2210/0057A61F2210/0061A61F2210/0076A61F2240/001A61L27/34A61L27/50A61L2430/10D04B21/12D10B2509/08Y10T428/249921Y10T428/249978Y10T442/2484Y10T442/419
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Quick Facts
Patent No.
US 11,672,646
App. No.
17/473,571
Granted
Jun 13, 2023
Kind
B2
Abstract

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

Claims (41)

1. A composite scaffold comprising:

a microporous matrix having a multitude of interconnected pores opening to an exterior surface of the microporous matrix; and

a structure supporting the microporous matrix comprising first and second outer layers separated by an interior space, and a plurality of spacer elements extending through the interior space and connecting the first and second outer layers, the microporous matrix being disposed within the interior space;

the composite scaffold having a measurable dry weight value representing a weight of the composite scaffold in a substantially dry state and a measurable dry volume value representing a volume of the composite scaffold in a substantially dry state,

wherein an increase of between approximately 200% and 600% of the dry weight value of the composite scaffold from fluid absorption changes the dry volume value of the composite scaffold between approximately 0% and 10%.

2. The composite scaffold of claim 1 wherein an increase of between approximately 300% and 600% of the dry weight value of the composite scaffold from fluid absorption changes the dry volume value of the composite scaffold between approximately 2% and 7%.

3. The composite scaffold of claim 1 wherein an increase of between approximately 300% and 600% of the dry weight value of the composite scaffold from fluid absorption changes the dry volume value of the composite scaffold between approximately 4% and 6%.

4. The composite scaffold of claim 1 wherein the composite scaffold has a measurable dry length value representing a dimensional parameter of the composite scaffold in a substantially dry state, and

wherein an increase of between approximately 300% and 600% of the dry weight value of the composite scaffold from fluid absorption changes the dry length value of the composite scaffold by between approximately 0% and 3%.

5. The composite scaffold of claim 1 wherein the composite scaffold has a measurable dry length value representing a dimensional parameter of the composite scaffold in a substantially dry state, and

wherein an increase of between approximately 300% and 600% of the dry weight value of the composite scaffold from fluid absorption changes the dry length value of the composite scaffold by between approximately 0% and 2%.

6. A composite scaffold comprising:

a microporous matrix having a multitude of interconnected pores opening to an exterior surface of the microporous matrix; and

a structure supporting the microporous matrix comprising first and second outer layers separated by an interior space, and a plurality of spacer elements extending through the interior space and connecting the first and second outer layers, the microporous matrix being disposed within the interior space;

the composite scaffold having a measurable dry weight value representing a weight of the composite scaffold in a substantially dry state and a measurable dry length value representing a dimensional parameter of the composite scaffold in a substantially dry state,

wherein an increase of between approximately 200% and 600% of the dry weight value of the composite scaffold from fluid absorption changes the dry length value of the composite scaffold by less than between approximately 0% and 3%.

7. The composite scaffold of claim 6 wherein an increase of between approximately 300% and 600% of the dry weight value of the composite scaffold from fluid absorption changes the dry length value of the composite scaffold by between approximately 0% and 2%.

8. The composite scaffold of claim 6 wherein an increase of between approximately 500% and 600% of the dry weight value of the composite scaffold from fluid absorption changes the dry length value of the composite scaffold less than approximately 1%.

9. The composite scaffold of claim 6 wherein the composite scaffold has a measurable dry volume value representing a volume of the composite scaffold in a substantially dry state, and

wherein an increase of between approximately 300% and 600% of the dry weight value of the composite scaffold from fluid absorption changes the dry volume value of the composite scaffold between approximately 2% and 7%.

10. The composite scaffold of claim 6 wherein the composite scaffold has a measurable dry volume value representing a volume of the composite scaffold in a substantially dry state, and

wherein an increase of between approximately 300% and 600% of the dry weight value of the composite scaffold from fluid absorption changes the dry volume value of the composite scaffold between approximately 4% and 6%.

11. A composite scaffold comprising:

a microporous matrix having a multitude of interconnected pores opening to an exterior surface of the microporous matrix; and

a structure supporting the microporous matrix comprising first and second outer layers separated by an interior space, and a plurality of spacer elements extending through the interior space and connecting the first and second outer layers, the microporous matrix being disposed within the interior space;

the composite scaffold having a measurable dry weight value representing a weight of the composite scaffold in a substantially dry state and a measurable cross sectional profile value representing a dimensional parameter of the composite scaffold in a substantially dry state,

wherein an increase of between approximately 300% and 600% of the dry weight value of the composite scaffold from fluid absorption changes the cross sectional profile value of the composite scaffold by between approximately 0% and 3%.

12. The composite scaffold of claim 11 wherein an increase of between approximately 300% and 600% of the dry weight value of the composite scaffold from fluid absorption changes the cross sectional profile value of the composite scaffold by between approximately 0% and 2%.

13. The composite scaffold of claim 11 wherein an increase of between approximately 500% and 600% of the dry weight value of the composite scaffold from fluid absorption changes the cross sectional profile value of the composite scaffold less than approximately 1%.

14. The composite scaffold of claim 11 wherein an increase of between approximately 300% and 600% of the dry weight value of the composite scaffold from fluid absorption increases the cross sectional profile value of the composite scaffold by between approximately 0% and 2%.

15. The composite scaffold of claim 11 wherein an increase of between approximately 500% and 600% of the dry weight value of the composite scaffold from fluid absorption increases the cross sectional profile value of the composite scaffold less than approximately 1%.

16. A composite scaffold comprising:

a microporous matrix having a multitude of interconnected pores opening to an exterior surface of the microporous matrix; and

a structure supporting the microporous matrix comprising first and second outer layers separated by an interior space, and a plurality of spacer elements extending through the interior space and connecting the first and second outer layers, the microporous matrix being disposed within the interior space;

wherein a smallest dimension of the composite scaffold is a thickness dimension approximately greater than or equal to 1 mm, and

wherein the composite scaffold has a swelling profile measurable by a less than or equal to 10% change in measured wet thickness of the composite scaffold in comparison to a measured dry thickness of the composite scaffold.

17. A composite scaffold comprising:

a microporous matrix having a multitude of interconnected pores opening to an exterior surface of the microporous matrix; and

a structure supporting the microporous matrix comprising first and second outer layers separated by an interior space, and a plurality of spacer elements extending through the interior space and connecting the first and second outer layers, the microporous matrix being disposed within the interior space;

the composite scaffold having a measurable dry weight value representing a weight of the composite scaffold in a substantially dry state,

wherein the microporous matrix is less than approximately 6% of the dry weight value of the composite scaffold.

Assignments (2)
SECURITY INTEREST Recorded Jul 21, 2025
From: CONMED CORPORATION; BIOREZ, INC.; BUFFALO FILTER LLC; IN2BONES USA, LLC; LINVATEC CORPORATION; SURGIQUEST, INC.; VIKING SYSTEMS, INC.
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 072097/0762 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 15, 2022
From: ROCCO, KEVIN A.; MOHANRAJ, BHAVANA; OTT, JEFFREY; BENDIGO, JUSTIN; KOMENDA, JACOB EDWARD; ARONSON, MARK THEODORE; CARTER, ANDREW JAMES
To: BIOREZ, INC.
Reel/Frame 059015/0201 →