Granted Patent
B2
US 12,245,585 · App. 17/473,840 · Granted Mar 11, 2025
Organ transport container with antiviral therapy
Assignee:
Paragonix Technonogies, Inc.
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Abstract
A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes an antimicrobial treatment mechanism to inactivate microbes flushed from the biological sample by preservation fluid flowed therethrough. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature while simultaneously treating microbial infections to prevent transmission between a donor and a recipient.
Claims (23)
1. A canister for transporting a biological sample, comprising:
a sample storage chamber comprising a floor and walls and configured to receive a biological sample;
a removable lid operable to couple with the walls to form a sterile environment within the sample storage chamber;
an adapter configured to couple to and support the biological sample within the sterile environment without the biological sample contacting the floor and the walls;
a plurality of cooling blocks positioned around an exterior of the canister;
a pumping mechanism operable to flow a perfusate in a circuit through the adapter, to perfuse the biological sample; and
an antimicrobial treatment mechanism disposed within the circuit, the antimicrobial treatment mechanism comprising a radiation source in the removable lid operable to inactivate microbes flushed from the biological sample by the perfusate,
wherein the removable lid comprises an opaque surface configured to optically isolate the radiation source from the biological sample.
2. The canister of claim 1 , wherein the radiation source is a light-emitting diode (LED).
3. The canister of claim 1 , wherein the pumping mechanism comprises an impeller driven by a motor.
4. The canister of claim 3 , wherein the impeller is operably coupled to the motor by a shaft and the shaft is sealed such that perfusate within the circuit does not contact the motor.
5. The canister of claim 3 , wherein the impeller is operably coupled to the motor by a magnetic coupling such that perfusate within the circuit does not contact the motor.
6. The canister of claim 1 , further comprising a pump for introducing a light-activated antimicrobial agent into the perfusate in the circuit, wherein the light-activated antimicrobial agent is activated by the radiation source.
7. The canister of claim 6 , wherein the light-activated antimicrobial agent comprises methylene blue.
8. The canister of claim 7 , wherein the radiation source is a light-emitting diode (LED) operable to emit red light.
9. The canister of claim 1 , wherein the radiation source emits ultraviolet C radiation in a range of between about 250 nm and about 270 nm.
10. The canister of claim 1 , further comprising a source of oxygen-containing gas.
11. The canister of claim 10 , wherein the source of oxygen-containing gas is in fluid communication with the perfusate in the circuit.
12. The canister of claim 10 , wherein the source of an oxygen-containing gas is a compressed gas cylinder.
13. The canister of claim 1 , wherein the biological sample comprises tissues or organs.
14. The canister of claim 1 , further comprising a pressure sensor or an oxygen sensor.
15. The canister of claim 1 , further comprising an insulated transport container containing the canister.
16. The canister of claim 15 , wherein the cooling blocks are positioned between the exterior of the canister and interior walls of the insulated transport container.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 13, 2024
From: JUDSON, JARED ALDEN; ANDERSON, LISA MARIA
To: PARAGONIX TECHNOLOGIES, INC.
Reel/Frame 067721/0842 →
SECURITY INTEREST
Recorded May 10, 2022
From: PARAGONIX TECHNOLOGIES, INC.
To: WESTERN ALLIANCE BANK
Reel/Frame 059878/0226 →
Continuity (3)
Continuation In Part
PCTUS2020037209
· Jun 11, 2020
Provisional Application
62860004
· Jun 11, 2019
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