Spiropyrrolidine derived antiviral agents
The present invention discloses compounds of Formula (Ia), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (Ia) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (Ia) or a pharmaceutically acceptable salt thereof.
1. A compound represented by Formula (XI-3),
wherein
each n is 0, 1, 2, 3, or 4;
R 3 is hydrogen, methyl or CD 3 ;
R 1 is C 1 -C 8 -alkyl or arylalkyl;
R 4 is hydrogen; and
each R 9 is halogen or C 1 -C 8 -alkoxy.
2. The compound of claim 1 , wherein the compound is
3. The compound of claim 1 , wherein the compound is
4. The compound of claim 1 , wherein the compound is
5. The compound of claim 1 , wherein the compound is
6. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier or excipient.
7. A pharmaceutical composition comprising the compound of claim 2 and a pharmaceutically acceptable carrier or excipient.
8. A pharmaceutical composition comprising the compound of claim 3 and a pharmaceutically acceptable carrier or excipient.
9. A pharmaceutical composition comprising the compound of claim 4 and a pharmaceutically acceptable carrier or excipient.
10. A pharmaceutical composition comprising the compound of claim 5 and a pharmaceutically acceptable carrier or excipient.
11. A method of treating a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound of claim 1 .
12. A method of treating a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound of claim 2 .
13. A method of treating a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound of claim 3 .
14. A method of treating a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound of claim 4 .
15. A method of treating a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound of claim 5 .