Spiropyrrolidine derived antiviral agents
The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.
1. A compound represented by Formula (XVI-A),
wherein
R 3a is hydrogen, methyl or CD 3 ;
R 1a is selected from the group consisting of
A is N(R 13a )(R 14a );
R 13a is hydrogen or CH 3 ; and
R 14a is C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl.
2. The compound of claim 1 , wherein the compound is
3. The compound of claim 1 , wherein the compound is
4. The compound of claim 1 wherein the compound is
5. The compound of claim 1 , wherein the compound is
6. The compound of claim 1 , wherein the compound is
7. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier or excipient.
8. A pharmaceutical composition comprising the compound of claim 2 and a pharmaceutically acceptable carrier or excipient.
9. A pharmaceutical composition comprising the compound of claim 3 and a pharmaceutically acceptable carrier or excipient.
10. A pharmaceutical composition comprising the compound of claim 4 and a pharmaceutically acceptable carrier or excipient.
11. A pharmaceutical composition comprising the compound of claim 5 and a pharmaceutically acceptable carrier or excipient.
12. A pharmaceutical composition comprising the compound of claim 6 and a pharmaceutically acceptable carrier or excipient.
13. A method of treating or preventing a SARS-CoV-2 infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound of claim 1 .
14. A method of treating or preventing a SARS-CoV-2 infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound of claim 2 .
15. A method of treating or preventing a SARS-CoV-2 infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound of claim 3 .
16. A method of treating or preventing a SARS-CoV-2 infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound of claim 4 .
17. A method of treating or preventing a SARS-CoV-2 infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound of claim 5 .
18. A method of treating or preventing a SARS-CoV-2 infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound of claim 6 .