Vagal nerve stimulation for treating central nervous system disorders
Devices, systems and methods are disclosed for treating one or more symptoms of central nervous system disorders in a patient, such as anxiety disorders, fibromyalgia, traumatic brain injury, PTSD, and others. A method includes positioning a contact surface of a device in contact with an outer skin surface of patient and applying an electrical impulse transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient for about 90 seconds to about 3 minutes. The electrical impulse is sufficient to modify the vagus nerve such that the symptoms of the central nervous system disorder are reduced. For chronic treatment of such disorders, a stimulation protocol is provided that includes two or more doses administered per day for a period of time sufficient to relieve the symptoms.
1. A method for treating symptoms of a central nervous system disorder in a patient, the method comprising:
positioning a contact surface of a device in contact with an anterior portion of an outer skin surface of a neck of a patient;
applying, via the device, when the contact surface is in contact with the outer skin surface of the patient, an electrical impulse transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient according to a stimulation protocol that includes at least two doses administered each day for a plurality of days; and
wherein the electrical impulse is sufficient to modify the vagus nerve such that the symptoms of the central nervous system disorder are reduced and wherein the electrical impulse comprises a burst period and a constant period, wherein each burst period comprises 2 to 20 pulses and wherein at least a portion of each constant period comprises zero pulses, wherein the burst period of each electrical impulse comprises sinusoidal waveforms which alternate between a positive and a negative electric field charge.
2. The method of claim 1 , wherein the device comprises one or more electrodes coupled to an energy source.
3. The method of claim 2 , further comprising attaching the one or more electrodes to the neck of the patient.
4. The method of claim 2 , wherein the device comprises a housing and the electrodes are part of the housing and wherein the energy source is housed within the housing.
5. The method of claim 1 , wherein the doses are separated by a time frame of about five to 15 minutes.
6. The method of claim 5 , wherein the stimulation protocol comprises 2 to 12 treatments/day.
7. The method of claim 1 , wherein the pulses have a frequency of about 1 kHz to about 20 kHz.
8. The method of claim 1 , wherein each burst period has a frequency of about 1 to about 100 bursts per second and each pulse has a duration of about 50 to about 1000 microseconds in duration.
9. The method of claim 1 , wherein the electrical impulse is sufficient to cause release of one or more types of inhibitory neurotransmitters in a brain of the patient.
10. The method of claim 9 , wherein the types of inhibitory neurotransmitters comprise one of GABA, serotonin, or norepinephrine.
11. The method of claim 1 , wherein the central nervous system disorder comprises fibromyalgia.
12. The method of claim 1 , wherein the central nervous system disorder comprises an anxiety disorder.
13. The method of claim 1 , wherein the central nervous system disorder comprises post-traumatic stress disorder (PTSD).
14. The method of claim 1 , wherein the central nervous system disorder comprises traumatic brain injury.