IP Library Granted Patent US 11,796,788
Granted Patent B2
US 11,796,788 · App. 17/490,767 · Granted Oct 24, 2023

Detecting a defect within a bodily sample

Inventors: Yochay Shlomo Eshel (Sde Warburg, IL); Natalie Lezmy (Hod Hasharon, IL); Dan Gluck (Kadima, IL); Arnon Houri Yafin (Jerusalem, IL); Joseph Joel Pollak (Neve Daniel, IL)
Assignee: S.D. Sight Diagnostics Ltd.
G02B21/367G01N21/8851G02B21/365G06T7/0012G06V20/693G06V20/698G01N2021/8887G06T2207/10056G06T2207/30024G06T2207/30101
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Quick Facts
Patent No.
US 11,796,788
App. No.
17/490,767
Granted
Oct 24, 2023
Kind
B2
Abstract

Apparatus and methods are described for analyzing a bodily sample. One or more microscope images of the bodily sample are acquired. Using at least one computer processor at least one sample-informative feature that is indicative of a characteristic of the bodily sample is extracted from the images. Based upon the sample-informative feature, the computer processor determines that there is a defect associated with the bodily sample, and determines a source of the defect. Other applications are also described.

Claims (70)

1. Apparatus for analyzing a bodily sample that contains blood, the apparatus comprising:

a microscope system configured to acquire one or more microscope images of the bodily sample;

an output device; and

at least one computer processor configured to:

perform a blood count on the bodily sample,

extract, from the one or more images, at least one sample-informative feature that is indicative of a characteristic of the bodily sample,

based upon the sample-informative feature:

determine that there is a defect associated with the bodily sample, and

determine a source of the defect, and

generate an output upon the output device, in response thereto.

2. The apparatus according to claim 1 , wherein the at least one computer processor is configured to generate an output indicating the source of the defect.

3. The apparatus according to claim 1 , wherein the apparatus is configured for use with a sample carrier and the microscope system is configured to acquire one or more microscope images of the bodily sample while the bodily sample is housed within the sample carrier, and wherein the at least one computer processor is configured to determine that the source of the defect is the sample carrier, based upon the sample-informative feature.

4. The apparatus according to claim 1 , wherein the computer processor is configured to perform a complete blood count on the sample that contains blood.

5. The apparatus according to claim 1 , wherein the apparatus is configured for use with a sample carrier and the microscope system is configured to acquire one or more microscope images of the bodily sample while the bodily sample is housed within the sample carrier, and wherein the at least one computer processor is configured to determine that the source of the defect is within a given portion of the sample carrier, based upon the sample-informative feature.

6. The apparatus according to claim 5 , wherein the at least one computer processor is configured to use data from other portions of the sample carrier as inputs for analyzing features of the bodily sample that are detected within the given portion of the sample carrier.

7. The apparatus according to claim 5 , wherein the at least one computer processor is configured to ascribe lower weight to features of the bodily sample that are detected within the given portion of the sample carrier relative to features of the bodily sample that are detected within other portions of the sample carrier.

8. The apparatus according to claim 5 , wherein the sample carrier contains a plurality of chambers, and wherein the at least one computer processor is configured to determine that the source of the defect is within a given chamber of the sample carrier, based upon the sample-informative feature.

9. The apparatus according to claim 5 , wherein the microscope system is configured to acquire microscope images of respective imaging fields of the bodily sample within the sample carrier, and wherein the at least one computer processor is configured to determine that the source of the defect is within a given set of imaging fields of the sample carrier, based upon the sample-informative feature.

10. The apparatus according to claim 5 , wherein the microscope system is configured to acquire microscope images of respective imaging fields of the bodily sample within the sample carrier, and wherein the at least one computer processor is configured to determine that the source of the defect is within a given imaging field of the sample carrier, based upon the sample-informative feature.

11. The apparatus according to claim 1 , wherein the at least one computer processor is configured to determine that the source of the defect is the bodily sample itself, based upon the sample-informative feature.

12. The apparatus according to claim 11 , wherein the at least one computer processor is configured to determine that the source of the defect is the bodily sample itself by detecting foreign objects within the bodily sample and determining that the amount of foreign objects that is detected within a given portion of the sample is proportional to the size of the portion of the sample.

13. The apparatus according to claim 12 , wherein, in response to detecting foreign objects within the bodily sample, the at least one computer processor is configured to adjust a threshold for diagnosis of a given condition based upon analysis of the bodily sample.

14. The apparatus according to claim 13 , wherein the bodily sample includes a blood sample, and wherein the at least one computer processor is configured to adjust a threshold for a number of pathogens within the blood sample that is sufficient to deem the blood sample to be infected based upon a relationship between a concentration of foreign objects within the blood sample and a concentration of red blood cells within the sample.

15. Apparatus for analyzing a bodily sample and configured for use with a diluent that is configured to dilute the bodily sample, the apparatus comprising:

a microscope system configured to acquire one or more microscope images of the bodily sample when the bodily sample is diluted by the diluent;

an output device; and

at least one computer processor configured to:

extract, from the one or more images, at least one sample-informative feature that is indicative of a characteristic of the bodily sample,

based upon the sample-informative feature:

determine that there is a defect associated with the bodily sample, and

determine that the source of the defect is the diluent, and

generate an output upon the output device, in response thereto.

16. The apparatus according to claim 15 , wherein the at least one computer processor is configured to determine that the source of the defect is the diluent by detecting foreign objects with characteristics that are common to a plurality of bodily samples.

17. The apparatus according to claim 15 , wherein the apparatus is configured for use with a sample carrier and the microscope system configured to acquire one or more microscope images of the bodily sample while the bodily sample is housed within the sample carrier.

18. The apparatus according to claim 17 , wherein the at least one computer processor is configured to determine that the source of the defect is the diluent by detecting foreign objects with characteristics that are common to a plurality of portions of the sample carrier.

19. The apparatus according to claim 17 , wherein the sample carrier contains a plurality of chambers, and wherein the at least one computer processor is configured to detect cross-contamination between chambers of the sample carrier.

20. A method for analyzing a bodily sample that is diluted by a diluent, the method comprising:

acquiring one or more microscope images of the bodily sample when the bodily sample is diluted by the diluent;

using at least one computer processor:

extracting, from the one or more images, at least one sample-informative feature that is indicative of a characteristic of the bodily sample,

based upon the sample-informative feature:

determining that there is a defect associated with the bodily sample, and

determining that a source of the defect is the diluent, and

generating an output, in response thereto.

21. Apparatus for analyzing a bodily sample that contains blood, the apparatus comprising:

a microscope system configured to acquire one or more microscope images of the bodily sample;

an output device; and

at least one computer processor configured to:

extract, from the one or more images, at least one sample-informative feature that is indicative of a characteristic of the bodily sample,

based upon the sample-informative feature:

determine that there is a defect associated with the bodily sample, and

determine that a source of the defect is the bodily sample itself, by detecting foreign objects within the bodily sample and determining that the amount of foreign objects that is detected within a given portion of the sample is proportional to the size of the portion of the sample, and

in response to detecting foreign objects within the bodily sample, adjust a threshold for diagnosis of a given condition based upon analysis of the bodily sample by adjusting a threshold for a number of pathogens within the blood in the bodily sample that is sufficient to deem the blood in the bodily sample to be infected based upon a relationship between a concentration of foreign objects within the blood in the bodily sample and a concentration of red blood cells within the blood in the bodily sample.

22. A method for analyzing a bodily sample that contains blood, the method comprising:

acquiring one or more microscope images of the bodily sample; and

using at least one computer processor:

extracting, from the one or more images, at least one sample-informative feature that is indicative of a characteristic of the bodily sample,

based upon the sample-informative feature:

determining that there is a defect associated with the bodily sample,

determining that a source of the defect is the bodily sample itself, by detecting foreign objects within the bodily sample and determining that the amount of foreign objects that is detected within a given portion of the sample is proportional to the size of the portion of the sample, and

in response to detecting foreign objects within the bodily sample, adjusting a threshold for diagnosis of a given condition based upon analysis of the bodily sample by adjusting a threshold for a number of pathogens within the blood in the bodily sample that is sufficient to deem the blood in the bodily sample to be infected based upon a relationship between a concentration of foreign objects within the blood in the bodily sample and a concentration of red blood cells within the blood in the bodily sample.

23. A method for analyzing a bodily sample that contains blood, the method comprising:

acquiring one or more microscope images of the bodily sample; and

using at least one computer processor:

performing a blood count on the bodily sample;

extracting, from the one or more images, at least one sample-informative feature that is indicative of a characteristic of the bodily sample;

based upon the sample-informative feature:

determining that there is a defect associated with the bodily sample, and

determining a source of the defect; and

generating an output upon an output device, in response thereto.

Assignments (5)
RELEASE OF INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Jan 23, 2025
From: KREOS CAPITAL VII AGGREGATOR SCSP
To: S.D. SIGHT DIAGNOSTICS LTD.
Reel/Frame 069993/0260 →
SECURITY INTEREST Recorded Dec 7, 2023
From: S.D. SIGHT DIAGNOSTICS LTD
To: KREOS CAPITAL VII AGGREGATOR SCSP
Reel/Frame 065788/0001 →
RELEASE OF SECURITY INTEREST Recorded Nov 28, 2023
From: BANK LEUMI LE-ISRAEL B.M.
To: S.D. SIGHT DIAGNOSTICS LTD.
Reel/Frame 065673/0880 →
SECURITY INTEREST Recorded Jul 3, 2022
From: S.D. SIGHT DIAGNOSTICS LTD.
To: BANK LEUMI LE-ISRAEL B.M.
Reel/Frame 060393/0580 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 30, 2021
From: ESHEL, YOCHAY SHLOMO; LEZMY, NATALIE; GLUCK, DAN; HOURI YAFIN, ARNON; POLLAK, JOSEPH JOEL
To: S.D. SIGHT DIAGNOSTICS LTD.
Reel/Frame 057660/0045 →